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Development of a three-dimensional scoring model for the assessment of continuous glucose monitoring data in type 1 diabetes
Introduction Despite the improvements in diabetes management by continuous glucose monitoring (CGM) it is difficult to capture the complexity of CGM data in one metric. We aimed to develop a clinically relevant multidimensional scoring model with the capacity to identify the most alarming CGM episodes and/or patients from a large cohort. Research design and methods Retrospective CGM data from 2017
The Gut Microbiota and Diabetes : Research, Translation, and Clinical Applications—2023 Diabetes, Diabetes Care, and Diabetologia Expert Forum
This article summarizes the state of the science on the role of the gut microbiota (GM) in diabetes from a recent international expert forum organized by Diabetes, Diabetes Care, and Diabetologia, which was held at the European Association for the Study of Diabetes 2023 Annual Meeting in Hamburg, Germany. Forum participants included clinicians and basic scientists who are leading investigators in
Clinical cell-surface targets in metastatic and primary solid cancers
Therapies against cell-surface targets (CSTs) represent an emerging treatment class in solid malignancies. However, high-throughput investigations of CST expression across cancer types have been reliant on data sets of mostly primary tumors, despite therapeutic use most commonly in metastatic disease. We identified a total of 818 clinical trials of CST therapies with 78 CSTs. We assembled a data s
Observations of Igneous Subsurface Stratigraphy during the Jezero Crater Floor Rapid Traverse from the RIMFAX Ground-penetrating Radar
Perseverance traversed the eastern, northern, and western margins of the Séítah formation inlier on the rover’s western fan front approach. Mapping the stratigraphy and extent of the Máaz and Séítah formations is key to understanding the depositional history and timing of crater floor resurfacing events. Perseverance's rapid progress across the Jezero crater floor between the Octavia E. Butler lan
Self-assessed performance-based function test versus patient-reported outcome measures for knee and hip osteoarthritis
BACKGROUND: Physical function constitutes a key component of outcome assessment for almost all osteoarthritis interventions. The aim was to compare physical function measured using a self-assessed performance-based test versus self-reported function using questionnaires among individuals with knee or hip osteoarthritis (OA) participating in a digital exercise and education therapy.METHODS: We anal
Dupuytren Disease : Treatment effect durability, recurrence, and patient-reported outcome measures
Monolingual comparative normativity in bilingualism research is out of “control”: Arguments and alternatives
Herein, we contextualize, problematize, and offer some insights for moving beyond the problem of monolingual comparative normativity in (psycho) linguistic research on bilingualism. We argue that, in the vast majority of cases, juxtaposing (functional) monolinguals to bilinguals fails to offer what the comparison is supposedly intended to do: meet the standards of empirical control in line with th
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We investigate the situation of heritage speakers in Italian language classes in a federal state in Germany, taking three perspectives: (i) the micro-perspective of heritage speakers, mostly fluent in Italian but often bidialectal, (ii) the meso-perspective of the teachers who must interact adequately with them, (iii) the macro-perspective of the education policies that determine the curriculum. T
Testing Potential Transfer Effects in Heritage and Adult L2 Bilinguals Acquiring a Mini Grammar as an Additional Language: An ERP Approach
Models on L3/Ln acquisition differ with respect to how they envisage degree (holisticvs. selective transfer of the L1, L2 or both) and/or timing (initial stages vs. development) of howthe influence of source languages unfolds. This study uses EEG/ERPs to examine these models,bringing together two types of bilinguals: heritage speakers (HSs) (Italian-German, n = 15) comparedto adult L2 learners (L1
Structural and phonological cues for gender assignment in monolingual and bilingual children acquiring German. : Experiments with real and nonce words
We investigate the acquisition of grammatical gender marking in German by monolingual children as well as German-Russian bilingual children who grow up in Germany as heritage speakers of Russian. We ask to what extent monolingual and bilingual children use phonological and/or structural cues to assign nominal gender, and to what extent they rely on lexical knowledge. To this end, we designed three
Foreign Accent in Pre- and Primary School Heritage Bilinguals
Previous research has shown that the two languages of early bilingual children can influence each other, depending on the linguistic property, while adult bilinguals predominantly show influence from the majority language to the minority (heritage) language. While this observed shift in influence patterns is probably related to a shift in dominance between early childhood and adulthood, there is l
Language history on fast forward : Innovations in heritage languages and diachronic change
There has been a substantial amount of research on heritage language acquisition and diachronic change. Although recent work has increasingly pointed to parallels between those two areas, it remains unclear how systematic these are. In this paper, we provide a bird's eye view, illustrating how patterns of diachronic change are mirrored in heritage language grammars. In doing so, we focus on one of
Terminology matters on theoretical grounds too! : Coherent grammars cannot be incomplete.
Herein, we provide counterargumentation to some of Domínguez, Hicks, and Slabakova's claims that the term incomplete acquisition is conceptually necessary on theoretical grounds for describing the outcome grammars of heritage language bilingualism. Specifically, we clarify their claim that previous challenging of the term in our and others’ work is primarily based on a misconceived belief that inc
Heritage language acquisition : What it reveals and why it is important for formal linguistic theories
This paper discusses the interplay between acquisition and theory construction. It endeavors to show how a more direct and crucially bi-directional relationship between formal linguistic theory and the study of heritage language bilingualism can provide mutual benefit. It will be argued that data from acquisition—not exclusively but indeed especially from heritage language bilingualism—provide win
Italian-German bilinguals : The effects of heritage language use on accent in early-acquired languages
This study investigates perceived accent in the two early-acquired languages of 21 adult-aged bilinguals with Italian as the heritage language (HL) and German as the majority language (ML). We test the relative ability of ‘age of onset (AoO) in German’ (range = 0–6 years) and ‘Italian use’ to predict perceived nativeness in Italian and German.
(The) polar bears are pink. How (the) Germans interpret (the) definite articles in plural subject DPs.
According to the literature, German optionally allows a definite article with generic nominals, whereas other Germanic languages require a bare nominal (e.g., English Polar bears are white). This optionality makes German different from other Germanic languages and more similar to Romance languages, in which definite articles are obligatory with generic nominals in subject positions. Since article
Prepositional phrases and case in North American (heritage) Icelandic
The paper investigates the use of PPs, specifically prepositions and the case marking on their DP arguments, in moribund North American (heritage) Icelandic (NAmIce), using data from a map task experiment. Since prepositional phrases combine semantic properties with morpho-syntactic properties, PPs allow us to investigate the relative vulnerability of both domains at once. Our results show that wh
Phonological vs. natural gender cues in the acquisition of German by simultaneous and sequential bilinguals (German–Russian)
We investigate German–Russian bilingual children's sensitivity to formal and semantic cues when assigning gender to nouns in German. Across languages, young children have been shown to primarily rely on phonological cues, whereas sensitivity to semantic and syntactic cues increases with age. With its semi-transparent gender assignment system, where both formal and semantic cues are psycho linguist
Voice Onset Time in multilingual speakers : Italian heritage speakers in Germany with L3 English
This study brings together two previously largely independent fields of multilingual language acquisition: heritage language and third language (L3) acquisition. We investigate the production of fortis and lenis stops in semi-naturalistic speech in the three languages of 20 heritage speakers (HSs) of Italian with German as a majority language and English as L3. The study aims to identify the exten