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Prenatal exposure to endocrine disrupting chemicals and the association with behavioural difficulties in 7-year-old children in the SELMA study

Background: Endocrine disrupting chemicals (EDCs) can cross the placenta and thereby expose the fetus, which may lead to developmental consequences. It is still unclear which chemicals are of concern regarding neurodevelopment and specifically behaviour, when being exposed to a mixture. Objective: The objective is to determine associations between prenatal exposure to EDCs and behavioural difficul

En ökad press att hantera utländsk påverkan i den akademiska sektorn: Bakgrund och utmaningar

Det globala akademiska landskapet har förändrats avsevärt sedan 1990-talet. Idag deltar fler länder än någonsin i produktionen av forskning av hög kvalitet, och internationella samarbeten inom högre utbildning har ökat markant under de senaste tre årtiondena på grund av globalisering och ökad personmobilitet. Det är tydligt att internationella utbyten och ökad personmobilitet har stärkt Sveriges f

Chromosome-scale genome assembly reveals how repeat elements shape non-coding RNA landscapes active during newt limb regeneration

Newts have large genomes harboring many repeat elements. How these elements shape the genome and relate to newts' unique regeneration ability remains unknown. We present here the chromosome-scale assembly of the 20.3 Gb genome of the Iberian ribbed newt, Pleurodeles waltl, with a hitherto unprecedented contiguity and completeness among giant genomes. Utilizing this assembly, we demonstrate conserv

Epithelial ovarian cancer is infiltrated by activated effector T cells co-expressing CD39, PD-1, TIM-3, CD137 and interacting with cancer cells and myeloid cells

INTRODUCTION: Despite predicted efficacy, immunotherapy in epithelial ovarian cancer (EOC) has limited clinical benefit and the prognosis of patients remains poor. There is thus a strong need for better identifying local immune dynamics and immune-suppressive pathways limiting T-cell mediated anti-tumor immunity.METHODS: In this observational study we analyzed by immunohistochemistry, gene express

How low can you go? : Antibiotic use in Swedish dogs with gastroenteritis

BACKGROUND: Canine gastroenteritis (CGE) is a common cause for seeking veterinary care in companion animal medicine and an area where antibiotics have been reported to be widely used. Therefore, creating relevant benchmarks for antibiotic use in CGE is important when implementing and analyzing antibiotic stewardship interventions. The aim of this paper was to describe the level and temporal trend

Sex hormones and sperm parameters after adjuvant oxaliplatin-based treatment for colorectal cancer

BACKGROUND: The incidence of colorectal cancer (CRC) in individuals of fertile age is increasing. Oxaliplatin is a cornerstone treatment in the adjuvant setting for stage III and high-risk stage II CRC. Limited data exist on possible side effects of oxaliplatin on fertility and gonadal function. More data is needed to guide possible fertility preservation procedures and aid evidence-based fertilit

Mechanisms of Damage to the Gastrointestinal Tract From Nonsteroidal Anti-Inflammatory Drugs

Nonsteroidal anti-inflammatory drugs (NSAIDs) can damage the gastrointestinal tract, causing widespread morbidity and mortality. Although mechanisms of damage involve the activities of prostaglandin-endoperoxide synthase 1 (PTGS1 or cyclooxygenase [COX] 1) and PTGS1 (COX2), other factors are involved. We review the mechanisms of gastrointestinal damage induction by NSAIDs via COX-mediated and COX-

Influence of oxygen concentration on T cell proliferation and susceptibility to apoptosis in healthy men and women

INTRODUCTION: Much of what we know about the functioning of human T lymphocytes is based on the experiments carried out in atmospheric oxygen (O₂) concentrations, which are significantly higher than those maintained in blood. Interestingly, the gender differences in the activity of T cells and their susceptibility to apoptosis under different O₂ conditions have not yet been described. The aim of t

Seasonal anomalies in radioactivity of the near-surface atmosphere in the Chernobyl-affected area of Belarus

Increased radioactivity in the near-surface atmosphere is virtually an annual occurrence in the Gomel region, Belarus. However, there is no explicit evidence as to what causes these anomalies and whether their origin has a strong seasonal association. To establish any such relations, we have analysed long-term radiation monitoring data recorded in the region over the past 17 years from 2003 to 202

Feasibility and Acceptability of Wearable Cameras to Assess Self-care in People With Heart Failure : Pilot Study

BACKGROUND: Heart failure (HF) is a common chronic condition that affects over 26 million people worldwide. It is a progressive and debilitating disease with a broad symptom profile, intermittently marked by periods of acute decompensation. People with HF generally do not self-manage their condition well (eg, monitoring symptoms, taking medications regularly, physical activity, etc). A better unde

Effects of acute hydration changes on cardiovascular magnetic resonance native T1 and T2 mapping

Changes in hydration status may affect myocardial native T1 and T2 values and influence the clinical interpretation. We aimed to assess the impact of acute preload augmentation on native T1 and T2. Cardiovascular magnetic resonance (CMR) native T1 and T2 mapping were performed twice on the same day in 20 healthy participants before and after an acute preload augmentation by a 2-liter intravenous i

Sustainability or instant gratification? A study on Chinese perspectives of ‘pay-as-you-use’ smart energy meters in budget hotels

In response to the growing demand for sustainable practices in the hospitality industry, many hotels have concentrated on operational measures to reduce energy consumption. However, the potential for promoting voluntary customer-initiated energy-saving behaviors has been largely overlooked. This study fills that gap by investigating how environmental values (egoistic, altruistic, and biospheric) a

The course of plasma alpha-1-microglobulin and haemolysis during cardiac surgery and the relationship to acute kidney injury, a pilot study

Haemolysis occurring during cardiac surgery with cardiopulmonary bypass (CPB) is assumed to be a risk factor for postoperative acute kidney injury (AKI). Plasma alpha-1 microglobulin (A1M) may have a protective role as haem scavenger. The aim of this study was to evaluate the association between AKI and the degree of haemolysis and the course of A1M concentrations during cardiac surgery, respectiv

Antibiotic Use in Dental Care of Dogs, Cats, and Rabbits in Sweden

Antimicrobial resistance is one of the largest threats to global health. In society as well as in healthcare facilities, antimicrobial resistance is rapidly increasing with the main reason being overuse and misuse of antibiotics combined with inadequate infection prevention. For humans, dental care accounts for about 10% of all antibiotic prescriptions, making it an important target for antibiotic

Neuropathological features of cerebrovascular diseases

Optimal blood flow through a patent cerebral circulation is critical for supply of oxygen and nutrients for brain function. The integrity of vascular elements within arterial vessels of any calibre can be compromised by various disease processes. Pathological changes in the walls of veins and the venous system may also alter the dynamics of cerebral perfusion. The consequences of both systemic vas

A mitotic CDK5-PP4 phospho-signaling cascade primes 53BP1 for DNA repair in G1

Mitotic cells attenuate the DNA damage response (DDR) by phosphorylating 53BP1, a critical DDR mediator, to prevent its localization to damaged chromatin. Timely dephosphorylation of 53BP1 is critical for genome integrity, as premature recruitment of 53BP1 to DNA lesions impairs mitotic fidelity. Protein phosphatase 4 (PP4) dephosphorylates 53BP1 in late mitosis to allow its recruitment to DNA les

Self-assembly of cationic surfactant in choline chloride-based deep eutectic solvents : structural solvation and dynamics

Deep eutectic solvents (DESs) have gained popularity in various applications due to their improved environmental sustainability and biodegradability. For the present study, several polyhydric alcohols, including ethylene glycol (EG), diethylene glycol (DEG), triethylene glycol (TEG), and glycerol (Gly), have been used as hydrogen bond donors (HBDs) and choline chloride (ChCl) as a hydrogen bond ac

Post-fire redistribution of 137Cs and algal communities in contaminated forest soils in Belarus

This study was carried out in the forest area of the Gomel region of Belarus contaminated by 137Cs following the Chernobyl accident of 1986. The aim of the study was to explore the effects of different types of wildfires on the biological availability of radionuclides and the distribution of algal communities in fire-affected soils. Soil samples were collected in 2017 and 2018 from sites burnt by