Neurodegenerative Biomarkers in Healthy Elderly - with special reference to the preclinical pattern of biological and cognitive markers for Alzheimer’s disease
Background: Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by tau and amyloid brain pathology. With the gradual degeneration of neurons, cognitive symptoms will arise and the affected individual will eventually develop AD dementia. The neuropathologic hallmarks of AD have been observed also in cognitively healthy individuals, which has led to the assumption that the disorde