Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 i

Aquaporin-9 (AQP9) is a membrane protein channel that is permeable to a range of small solutes, including glycerol, urea and nucleobases. Expression of AQP9 in normal brain is limited, while widespread AQP9 expression has previously been reported in human glioblastoma. However, the specific cellular expression of AQP9 in glioblastoma remains unclear. In this study, we have examined microarrays to

In the post-genomic era, it has become evident that genetic changes alone are not sufficient to understand most disease processes including pancreatic cancer. Genome sequencing has revealed a complex set of genetic alterations in pancreatic cancer such as point mutations, chromosomal losses, gene amplifications and telomere shortening that drive cancerous growth through specific signaling pathways

Whole strawberries were vacuum infused with cryoprotectants to improve their freezing tolerance. The strawberries were infused with 12 g/100 g trehalose solution; 0.2 g/100 g cold-acclimated wheatgrass solution (AWWE) containing antifreeze protein (AFP) or combination of 12 g/100 g trehalose with 0.2 g/100 g AWWE under vacuum for 14 mm. The fruits were frozen in liquid nitrogen and thawed at room

The angle-resolved resonant Auger spectrum of Xe is investigated with a record high meV energy resolution in the kinetic energy region of 34.45-39.20 eV at hv = 65.110 eV, corresponding to the resonant excitation of the Auger Xe* 4d(5/2)(-1)6p state. New lines have been observed and assigned in the spectra. The results of previous measurements concerning energies, intensities and angular distribut

The biogenicity of ancient morphological microfossil-like objects can be established by linking morphological (e.g. cell remnants and extracellular polymeric matrix) and chemical (e.g. isotopes, biomarkers and biominerals) evidence indicative of microorganisms or microbial activity. We have developed a non-destructive micro-analytical ion beam system capable of measuring with high spatial resoluti

In 2012 a Swedish project was initiated to study and document the archaeological remains at Gebel el Silsila, located about 65 km north of Aswan and 130 km south of Luxor. Mission director Dr. Maria Nilsson of Lund University summarizes the results of the first three seasons.

OBJECTIVE: People with disabilities find it harder to enter the labour market than people without disabilities and those with a mental illness are, in relation to people with other disabilities, employed at an essentially lower extent. Many are effectively helped by the vocational rehabilitation model Individual Placement and Support (IPS), but there are still many individuals left in undesired un

The paper attempts to give a solution to the Fitch's paradox though the strategy of the reformulation of the paradox in temporal logic, and a notion of knowledge which is a kind of ceteris paribus modality. An analogous solution has been offered in a different context to solve the problem of metaphysical determinism.

We apply Floquet theory to explore the geometry of the Hilbert space under the influence of a time-periodic field. The geometrical phase is found to be induced by field-driven hybridizations when the photon energy of the driving field is close to the transition energies of the states of a quantum system. The phases of two hybridized states are phase locked to each other. We show that the geometric

As downscaling of semiconductor devices continues, one or a few randomly placed dopants may dominate the characteristics. Furthermore, due to the large surface-to-volume ratio of one-dimensional devices, the position of the Fermi level is often determined primarily by surface pinning, regardless of doping level. In this work, we investigate the possibility of tuning the Fermi level dynamically wit

Aquifers and groundwater-dependent ecosystems (GDEs) are facing increasing pressure from water consumption, irrigation and climate change. These pressures modify groundwater levels and their temporal patterns and threaten vital ecosystem services such as arable land irrigation and ecosystem water requirements, especially during droughts. This review examines climate change effects on groundwater a

Abstract in UndeterminedUsing data on institutional quality and the KOF Globalization Index, we examine over 100 countries from 1992 to 2010 to analyse the relationship between economic and social globalization and six measures of institutional quality, thereby testing Montesquieu's doux commerce thesis, that economic and social interaction lead to improved institutional quality. Results suggest t

Several articles within the area of green chemistry often promote new techniques or products as 'green' or 'more environmentally benign' than their conventional counterpart although these articles often do not quantitatively assess the environmental performance. In order to do this, life cycle assessment (LCA) is a valuable methodology. However, on the planning stage, a full-scale LCA is considere

Cell proliferation affects both cellular geometry and topology in a growing tissue, and hence rules for cell division are key to understanding multicellular development. Epithelial cell layers have for long times been used to investigate how cell proliferation leads to tissue-scale properties, including organism-independent distributions of cell areas and number of neighbors. We use a cell-based t

The small size of the billions of migrating songbirds commuting between temperate breeding sites and the tropics has long prevented the study of the largest part of their annual cycle outside the breeding grounds. Using light-level loggers (geolocators), we recorded the entire annual migratory cycle of the red-backed shrike Lanius collurio, a trans-equatorial Eurasian-African passerine migrant. We