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Death rate and recurrence pattern among 841 clinical stage I endometrial cancer patients with special reference to uterine papillary serous carcinoma

Eight hundred thirty-nine clinical stage I endometrial carcinoma patients diagnosed between 1979 and 1988 were treated at the University Hospital in Linköping. Forty-two (5%) had uterine papillary serous carcinoma of which 52% died of their disease. The recurrence rate, defined as new evidence of disease 6 months or more after termination of the initial treatment, was 31% among the UPSC patients c

Treatment results and prognostic factors in a population-based study of epithelial ovarian cancer

The Swedish Tumor Registries are population based. Three hundred eighty-four patients with epithelial ovarian cancer registered in the Tumor Registry of the Southeast Health Care Region during the years 1984 to 1987 were reviewed; 332 patients were eligible for survival analysis. The protocol treatment during this period included primary surgery aimed at tumor reduction followed by combination che

Efficacy and tolerability of tropisetron and dexamethasone in the control of nausea and vomiting induced by cisplatin

A multicentre study was performed at four oncology centres in Sweden, in 160 chemotherapy-naive women, primarily with ovarian or endometrial carcinomas. Abdominal surgery preceded chemotherapy in 146 (91%) women, and another 39 (24%) women had a history of radiotherapy. The chemotherapy regimens contained cisplatin (50-100 mg/m2), in combination with a variety of other agents. In Course 1, all pat

Long-term follow-up of ovarian cancer with monthly determinations of serum CA 125

Monthly serum CA 125 determinations were used for monitoring of 33 patients with advanced nonmucinous epithelial ovarian cancer during the follow-up after the primary treatment. The observation time ranged between 3 and 7 years. All patients had elevated CA 125 levels at the start of chemotherapy with subsequent normalization during treatment. Seventeen patients were classified as having no eviden

Nuclear morphometry : a strong prognostic factor for survival after secondary surgery in advanced ovarian cancer

Nuclear morphometry was performed on the diagnostic biopsy in 65 cases of non-mucinous ovarian carcinoma (FIGO stage IIB-IV) and its prognostic value regarding patient survival after the second-look operation was compared to that of morphology and clinical observations. In a univariate Cox survival analysis four morphometric factors were found to be significant predictors of survival (the standard

Postmenopausal extragenital choriocarcinoma. A case report and review of the literature

A case is presented of extragenital abdominal choriocarcinoma without uterine lesion in a postmenopausal woman. Nineteen years after her antecedent pregnancy, a legal abortion, and thirteen years after her menopause, the patient was admitted to the hospital because of intermittent abdominal pain. Explorative laparotomy revealed a large tumour mass in the greater omentum, mesosigmoideum, peritoneal

Optimality interpretations for atomic norms

Atomic norms occur frequently in data science and engineering problems such as matrix completion, sparse linear regression, system identification and many more. These norms are often used to convexify non-convex optimization problems, which are convex apart from the solution lying in a non-convex set of so-called atoms. For the convex part being a linear constraint, the ability of several atomic n

Serum half-life of the tumor marker CA 125 during induction chemotherapy as a prognostic indicator for survival in ovarian carcinoma

Patients (n = 72) with newly diagnosed non-mucinous ovarian carcinomas, FIGO stages IIC-IV, and CA 125 levels raised when starting chemotherapy were followed both by serial serum CA 125 tumor marker determinations during induction chemotherapy and by second-look operation after 4-6 cycles of chemotherapy. Patients with complete response at the second-look operation (n = 19) had an estimated surviv

The use of chordotomy to treat pain from gynecologic cancer

Tumor growth in the pelvis with nerve involvement causes severe pain which is notoriously resistant to pharmacological treatment. Chordotomy is a classical method for the relief of pain. This is a retrospective study of 24 chordotomy cases, operated on at the department of Neurosurgery, and independently evaluated at the department of Gynecologic Oncology. Initially 19 patients (79%) were painfree

Sparsity-constrained optimization of inputs to second-order systems

We propose an efficient algorithm, that given a strictly proper, second-order system, finds a sparse input signal so that the system's output optimally approximates a given trajectory in least-squares sense. As an illustration, we apply the algorithm to an estimation problem from medicine.

Effects of high ambient pressure on resistance to anoxia in mice

The resistance of mice to asphyxiation in pure nitrogen at 5 ata, after equilibration with a high pressure atmosphere (4.2 % O2 in N2, 5 ata; “normal” Po2) producing a nitrogen anaesthesia, has been compared to the resistance of mice exposed to pure nitrogen at 1 ata after atmospheric air breathing. The anoxic resistance was increased by 58 % by the nitrogen anaesthesia.

Using Radial Basis Functions to Approximate the LQG-Optimal Event-Based Sampling Policy

A numerical method based on radial basis functions (RBF) has been developed to find the optimal event-based sampling policy in an LQG problem setting. The optimal sampling problem can be posed as a stationary partial differential equation with a free boundary, which is solved by reformulatingthe optimal RBF approximation as a linear complementarity problem (LCP). The LCP can be efficiently solved

Conceptualising dimensions of bibliometric assessment: From resource allocation systems to evaluative landscapes

The purpose of this paper is to discuss the conceptualisation of bibliometric analyses in terms of the levels on which they are performed, adding contextual factors to the dimension where the size of the unit being analysed is considered. Based on empirical investigations of resource allocation systems and research evaluation practices, as well as the previous literature conceptualising bibliometr

GFORCE-PD still going strong in 2016

In 2014, a new initiative was undertaken by groups working on plans for the transplantation of stem-cell-based derived dopaminergic neurons for treating Parkinson’s disease patients. This GForce-PD group held its annual meeting on 18–19 April 2016 in Chicago at Rush University to discuss their progress and the challenges that the translation of this experimental therapy still faces. Over 2 days, t

Bacterial virulence or exorbitant host response? On innate immunity against the streptococcal M1 protein.

Bacterial infection is inevitable throughout a lifetime. What differs between mild andserious infections is the pathogen responsible and how the host immune systemresponds to it. A fundamental role to prevent infection is a proper physical barrier such as the skin and mucosa. However, sometimes abrasions or injuries are still introduced, being potential ports of entry for pathogenic bacteria. An a

Diplomatic law of international organizations: structuration and its place in the general system of international law

This article examines the methodological issues of structuring the diplomatic law of international organizations, its place in the system of international law. The interdisciplinary nature of the diplomatic law of international organizations, its relationship with diplomatic and consular law and the law of international organizations has been disclosed. An emphasis is given to the main features an