Current treatment guidelines refer to small cell lung cancer (SCLC), one of the deadliest human malignancies, as a homogeneous disease. Accordingly, SCLC therapy comprises chemoradiation with or without immunotherapy. Meanwhile, recent studies have made significant advances in subclassifying SCLC based on the elevated expression of the transcription factors ASCL1, NEUROD1, and POU2F3, as well as o

This presentation provides an overview of the state of the evidence with respect to the prevalence, aetiology, and treatment of pediatric Posttraumatic Stress Disorder with an emphasis on the first-line, recommended treatment - trauma-focused cognitive behavioral therapies. The presenter also details findings from his recent research on the relative efficacy of a writing-based form of CBT and EMDR

This chapter offers a reflection on how privacy can be theorized as a distinct form of sphere, namely an atmosphere. Drawing on perspectives from phenomenology and aesthetics, ‘Atmospheres of privacy’ provides a conceptual framework for exploring the embodied and felt experience of privacy in everyday lived spaces. The chapter discusses two cases from contemporary surveillance culture in which dom

This clinical workshop is aimed at child and adolescent mental health professionals. The workshop will focus on two interventions found in all first-line, evidence-based treatments for PTSD: exposure to the trauma memory and reminders, and cognitive restructuring of trauma-related beliefs. Participants will learn about the various way that effective exposure can be achieved through writing, oral r

China's technological growth in recent years has been explosive. Nowadays, Beijing based much of its socio-economic growth on improved technological performance in many areas. What are the main reasons that have enabled China to become a real IT giant? What are the geo-strategic implications of such growth in technology? To what extent can Chinese technical engineering improvements influence the c

The technological push for hydrogen-based steel production has become a flagship project of the Swedish state for advancing its global environmental leadership and becoming the world's first fossil free welfare state. The new production process has the potential to drastically cut emissions in a heavy polluting industry. The plans also entail a drastic upscale in steel production, energy and iron

China is a global leader in the manufacturing of clean energy. Unexpectedly, the severe environmental degradation occurring since the 1990s and the critical air pollution situation are now under control. Many steps still need to be taken in order to fix all the problems linked with the long-term environmental crisis. However, since Xi Jinping’s advent to power in 2012, Beijing has undertaken a sol

Introduction: Anxiety disorders are common and debilitating in children and adolescents. Cognitive behavioral therapy (CBT), delivered both in-person and by the internet (ICBT), is efficacious, but access for young individuals is limited and it remains unclear how to structure the care pathway to maximize benefit.Methods: To inform a fully powered randomized controlled trial (RCT), a pilot RCT wil

Turkey is an exceedingly prosperous nation in terms of water. The Tigris and Euphrates, two of the most famous and iconic watercourses in the Middle East (and beyond), flow from the Anatolian mountains within Turkey's borders. This gives Ankara enormous power in geopolitical terms, especially towards the Arab countries downstream, which have always grappled with worrying water supply crises. Over

Children and adolescents exposed to traumatic events are at high risk of developing posttraumatic stress disorder (PTSD). With the rare exception of very young children, their PTSD presentations at the symptom level are similar to those of trauma-exposed adults, as are their patterns of psychiatric comorbidity, particularly for adolescents. Untreated, at least a significant proportion will carry o

Since 1988, China's influence in Myanmar, both on a political and financial scale, has been relevant. Following the democratic bend that occurred in former Burma in 2011 and the ensuing opening to global markets, Beijing has partially lost its long-held privileges in the country. In order to maintain a solid geo-economic supremacy in Naypyitaw's internal affairs, since 2006, China has embarked upo

This paper explores how Ukrainian virtual museums of war are embedded in today’s connective environment of humans, codes and algorithms. In particular, I examine the ways virtuality as a mode of memory-making is deployed by the Meta History: Museum of War to shape the mediation and remembering of the full-scale Russian war against Ukraine as it unfolds. Using digital methods and digital ethnograph

The ability to encode, imagine, and remember coherent representations of the world is crucial for everyday life and depends on a brain network involving the hippocampal region. Scene construction tasks, which measure spatial coherence, have been shown to be sensitive to hippocampal integrity in amnesic patients. Hippocampal dysfunction has been implicated in posttraumatic stress disorder (PTSD), a

We define a new class of Gaussian processes on compact metric graphs such as street or river networks. The proposed models, the Whittle–Matérn fields, are defined via a fractional stochastic differential equation on the compact metric graph and are a natural extension of Gaussian fields with Matérn covariance functions on Euclidean domains to the non-Euclidean metric graph setting. Existence of th

Background: Despite continuous improvements in anti-rheumatic pharmacological treatment, people with chronic inflammatory arthritis still report substantial disease impact. Based on the framework for complex interventions, we thus developed INSELMA, a novel nurse-coordinated multidisciplinary self-management intervention for patients with rheumatoid arthritis, psoriatic arthritis or axial spondylo

Gene therapy using adeno-associated viral (AAV) vectors is a promising approach for the treatment of monogenic disorders. Long-term multi-year transgene expression has been demonstrated in animal models and clinical studies. Nevertheless, uncertainties remain concerning the nature of AAV vector persistence and whether there is a potential for genotoxicity. Here, we describe the mechanisms of AAV v