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The standard 11-lead ECG. Neglect of lead aVR in the classical limb lead display

This study investigates how the format of limb lead display influences electrocardiographic (ECG) interpretation. The positive aspect of lead aVR (included in the classical display) is directed opposite to that of the other leads. This could lead to an ECG interpreter's disregard of lead aVR, thus providing a "standard 11-lead ECG." It is hypothesized that when using the classical limb lead displa

The Qualities of Qualia

This essay is a defence of the traditional notion of qualia - as properties of consciousness that are ineffable, intrinsic, private and immediately apprehensible - against the eliminative attempts of Daniel Dennett in the inþuential article "Quining Qualia." It is suggested that a thorough exploration of the concept is an appropriate starting point for future explanations of qualia, and the essay

Effects of cooling on muscle function and duration of stance phase during gait

Introduction: Cold exposure alters muscular function. Muscle cooling influences the neuromuscular activation during maximal isometric voluntary contractions (MVC) and the amplitude of surface electromyography (sEMG) [1],[2]. It also slows down the mechanical process during contraction [3]. The purpose of this study was to investigate the effects of local cooling in cold water at 10 °C for 20 min i

Preparations for discussing constructivism with a Martian

It is easy to demonstrate the naivety of many people preparing messages for intelligent beings on other planets using pictures. On the other hand, constructivism, which supposes all our perception to rely on social constructs, has long been shown to be untenable, notably by Gibson, who instead suggested that some general ecological principles have to be taken into account. In a parallel fashion, I

Anti-Sclerostin antibody and mechanical loading appear to independently influence metaphyseal bone in rats

Background and purpose Sclerostin is produced by osteocytes and is an inhibitor of bone formation. Thus, inhibition of sclerostin by a monoclonal antibody increases bone formation and improves fracture repair. Sclerostin expression is upregulated in unloaded bone and is downregulated by loading. We wanted to determine whether an anti-sclerostin antibody would stimulate metaphyseal healing in unloa