A case of acute interstitial nephritis caused by sodium valproate is reported. The sodium valproate treatment was continued after initial diagnosis and the patient developed end-stage renal failure. After transplantation, interstitial nephritis was demonstrated in the renal graft.

α-Galactosidases are important industrial enzymes for hemicellulosic biomass degradation or modification. In this study, six novel extracellular α-galactosidases from Penicillium subrubescens were produced in Pichia pastoris and characterized. All α-galactosidases exhibited high affinity to pNPαGal, and only AglE was not active towards galacto-oligomers. Especially AglB and AglD released high amou

The possible implication of the gasotransmitters NO and CO for the development of diabetes remains unresolved. Our previous investigations in rodents suggested NO being inhibitory, and CO stimulatory, to glucose-stimulated insulin secretion (GSIS). Here we studied the possible role of these gasotransmitters in both murine and human type 2 diabetes (T2D) by mapping the expression pattern of neural

This paper shows how the Computer Revolution of the 1980s shifted the economic trajectories of U.S. cities. Examining the emergence of new occupational titles in official census classifications, we document a sharp reversal in the skill content of new jobs. While technological change was biased towards routine skills throughout the 1970s, new job titles mainly appeared in occupations and industrie

Aim: Vegetation structure is a key determinant of animal diversity and species distributions. The introduction of Light Detection and Ranging (LiDAR) has enabled the collection of massive amounts of point cloud data for quantifying habitat structure at fine resolution. Here, we review the current use of LiDAR‐derived vegetation metrics in diversity and distribution research of birds, a key group f

Using water balance computations, the behavior of different kinds of lakes is discussed. Simple analytical expressions relating water level to hydrological conditions and lake bathymetry are given. The importance of knowing the river basin area when analyzing lake levels is stressed. A conceptual rainfall-runoff model including lake routing is used to simulate runoff and lake levels and to compute

We use a combination of field and satellite data to investigate the thermal regime in Lake Ladoga in spring 1992. The analysis concentrates mainly on the temperature structure in the convectively mixed region and the dynamics of a special thermo‐hydrodynamic phenomenon called “thermal bar” (a zone of descending water with the temperature of maximum density equal to ∼4°C). A theoretical model of th

Hösten 1971 släppte en ny grupp från Malmö, Hoola Bandoola Band, sitt första album, Garanterat individuell, vilket kom att få stor spridning och innebära gruppens genombrott i den svenska populärmusikgenren. En av de sånger som har kommit att göra albumet ihågkommet genom flera decennier är Fred (Till Melanie)skriven av Mikael Wiehe. Den drygt 13 minuter långa sången avslutar albumet och är av när

This paper investigates the empirical relationship between countries’ expressed concerns with fairness and the ambition levels in their pledged contributions (NDCs) to the Paris Agreement, asking the following questions: 1) Are the NDCs of countries who express the most concern with fairness more or less ambitious than those of other countries? 2) Does the relationship between fairness and ambitio

One of the most important trends in contemporary tourism is the increase in urban tourism, both in absolute and in relative terms. In some destinations, e.g. Barcelona, the pressure from tourism on local resources such as housing and urban space has reached a point where we begin to speak about overtourism. The development of overtourism is related to decreasing relative costs of travel, e.g. low-

Torch-plasma-grown single-walled carbon nanotubes (SWCNTs) are integrated with regioregular poly(3-hexylthiophene) (P3HT) and a fullerene derivative 1-(3-methoxycarbonyl) propyl-1-phenyl[6,6]C61 (PCBM) as a hybrid photoactive layer for bulk heterojunction solar cell devices. We demonstrate that molecular information could be accurately obtained by time-of-flight secondary ion mass spectrometry thr

The molecular chaperone HSP90 facilitates the folding of several client proteins, including innate immune receptors and protein kinases. HSP90 is an essential component of plant and animal immunity, yet pathogenic strategies that directly target the chaperone have not been described. Here, we identify the HopBF1 family of bacterial effectors as eukaryotic-specific HSP90 protein kinases. HopBF1 ado

The breakup of the L-chondrite parent body in the asteroid belt 466 million years (Ma) ago still delivers almost a third of all meteorites falling on Earth. Our new extraterrestrial chromite and 3He data for Ordovician sediments show that the breakup took place just at the onset of a major, eustatic sea level fall previously attributed to an Ordovician ice age. Shortly after the breakup, the flux

Lignocellulose from terrestrial plant biomass is abundant and contains polymeric carbohydrates and lignin; both recognized as attractive renewable feedstocks for energy, chemicals and materials as alternatives to fossils to meet the targets for future sustainable development. Liquid biofuels are particularly important renewable commodities because of the vast infrastructure already in place to use

Catholics and Protestants assumed that God instituted the family and that it had certain spiritual functions to perform. In 1985, Colleen McDannell addressed changes in Christian perceptions of the home and family in nineteenth-century America. This chapter focuses on Christian ideas of the home and family in nineteenth-century Europe and touches on similar themes to those discussed by McDannell,