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Associations of cigarette smoking with disease phenotype and type I interferon expression in primary Sjögren's syndrome

Several studies have shown a negative association between smoking and primary Sjögren's syndrome (pSS), and smoking may interfere with the immune response. The purpose of this study was to investigate if smoking affects disease activity and disease phenotype in pSS. In this cross-sectional study, consecutive pSS patients filled out the EULAR Sjögren's Syndrome Patient Reported Index (ESSPRI) form

Concomitant Ro/SSA and La/SSB antibodies are biomarkers for the risk of venous thromboembolism and cerebral infarction in primary Sjögren's syndrome

OBJECTIVES: To assess the risk of incident cardiovascular disease in patients with primary Sjögren's syndrome, overall and stratified by Ro/SSA and La/SSB autoantibody status.METHODS: A cohort of patients with primary Sjögren's syndrome in Sweden (n=960) and matched controls from the general population (n=9,035) were included, and data extracted from the National Patient Register to identify event

Inherited Classical and Alternative Pathway Complement Deficiencies in Children : A Single Center Experience

BACKGROUND: Primary complement deficiencies are rare diseases. OBJECTIVE: To retrospectively evaluate the clinical and laboratory findings and complications of patients to increase awareness of pediatricians about complement deficiencies, which are rarely encountered. METHODS: In this study, the clinical and immunological characteristics of 21 patients who consulted the Immunology Department of ou

Accessing Information in Order to Manage The Strain of a New Demanding Role : A Qualitative Study of the Next of Kin of Patients after Colorectal Cancer Surgery

Objectives: The aim of this study was to explore next of kin’s experiences ofinformation and their information needs after the patient’s discharge for colorectal cancer surgery.Methods: Sixteen next of kin were interviewed twice during the first seven weeksafter the patient’s discharge from hospital. The interviews were analysed through qualitative content analysis.Results: The participants in thiObjectives: The aim of this study was to explore next of kin’s experiences of information and their information needs after the patient’s discharge for colorectal cancer surgery.Methods: Sixteen next of kin were interviewed twice during the first seven weeks after the patient’s discharge from hospital. The interviews were analysed through qualitative content analysis.Results: The participants in t

Archeovirtual 2011 : An evaluation approach to virtual museums

November 2011 saw the opening of the exhibition "Archeovirtual" organized by CNR ITABC - Virtual Heritage Lab - and V-MusT Network of Excellence, in Paestum, Italy, under the general direction of BMTA1. The event, that was part of a wider European project focus on virtual museums, turned to be a great opportunity to show many different projects, applications and installations about Virtual Reality

Burden of cardiovascular disease across 29 countries and GPs’ decision to treat hypertension in oldest-old

Objectives: We previously found large variations in general practitioner (GP) hypertension treatment probability in oldest-old (>80 years) between countries. We wanted to explore whether differences in country-specific cardiovascular disease (CVD) burden and life expectancy could explain the differences. Design: This is a survey study using case-vignettes of oldest-old patients with different como

Evidence of household transfer of ESBL-/pAmpC-producing Enterobacteriaceae between humans and dogs - a pilot study

BACKGROUND: Extended-spectrum cephalosporin-resistant Enterobacteriaceae (ESCRE) are an increasing healthcare problem in both human and veterinary medicine. The spread of ESCRE is complex with multiple reservoirs and different transmission routes. The aim of this study was to investigate if ESCRE carriage in dogs is more prevalent in households with a known human carrier, compared to households wh

Postherpetic neuralgia, diabetic neuropathy, and trigeminal neuralgia - Chronic peripheral neuropathic pain in 58,480 rural Italian primary care patients

INTRODUCTION: Chronic peripheral neuropathic pain (CPNP) is a condition due to peripheral nervous system diseases or injury, but its prevalence is unknown in Italian primary care.AIM: The aim of this study is to assess the prevalence of CPNP in a rural primary care area in Northern Italy.MATERIALS AND METHODS: A multicenter audit study was carried out in a rural area in Northern Italy with 113 par