On the interpretation of the observed linear free energy relationship in phosphate hydrolysis : a thorough computational study of phosphate diester hydrolysis in solution
The hydrolysis of phosphate esters is crucially important to biological systems, being involved in, among other things, signaling, energy transduction, biosynthesis, and the regulation of protein function. Despite this, there are many questions that remain unanswered in this important field, particularly with regard to the preferred mechanism of hydrolysis of phosphate esters, which can proceed th