Molecular targeted therapy using a drug that suppresses the growth and spread of cancer cells via inhibition of a specific protein is a foundation of precision medicine and treatment. High expression of the proto-oncogene Bcl-3 promotes the proliferation and metastasis of cancer cells originating from tissues such as the colon, prostate, breast, and skin. The development of novel drugs targeting B

Metalloporphyrins with open d-shell ions can drive biochemical energy cycles. However, their utilization in photoconversion is hampered by rapid deactivation. Mapping the relaxation pathways is essential for elaborating strategies that can favorably alter the charge dynamics through chemical design and photoexcitation conditions. Here, we combine transient optical absorption spectroscopy and trans

This chapter examines the response of five prominent Swedish economists, David Davidson, Gustav Cassel, Eli Heckscher, Knut Wicksell and Bertil Ohlin, to John Maynard Keynes’s The Economic Consequences of the Peace and to the German reparations in the 1920s. When Keynes’s book appeared, Davidson and Cassel strongly endorsed it. Heckscher also agreed with Keynes in a long review entitled “Too Bad t

”Än så länge finns inga tecken på att globaliseringen börjar gå baklänges. Den expanderar inte längre, men jag kan inte säga att vi är inne i en period av stark återgång ännu”, säger Fredrik N G Andersson.Han forskar om kriser och ekonomisk politik, och är docent i nationalekonomi vid Ekonomihögskolan vid Lunds universitet.

This doctoral thesis consists of three independent research papers. All papers are empirical and cover the area of international trade and environmental economics, with particular focus on Swedish manufacturing firms. The first paper investigates how carbon offshoring could contribute to cleaner production. Using Swedish firm-product level data from 2005-2014, combined with instrumental variable a

The recently discovered selective glomerular hypofiltration syndromes have increased interest in the actual elimination of molecules in the human kidney. In the present study, a novel human model was introduced to directly measure the single-pass renal elimination of molecules of increasing size. Plasma concentrations of urea, creatinine, C-peptide, insulin, pro-BNP, β2-microglobulin, cystatin C,

This thesis deals with the development and application of new estimation methods of heterogenous panel data models. In Paper I, a new estimator for heterogeneous panel data models with random interactive effects is proposed. The heterogeneity in this paper is viewed as heterogeneity over time, which is modeled by having the slope coefficients exhibit multiple structural breaks. The suggested estim

ObjectiveTo examine changes in prevalence and socioeconomic inequalities in knee and hip OA outcomes, in more specific surgery and non-surgery specialist care visits, from 2001 to 2011 in Sweden and to what extent sociodemographic factors can explain the changes.DesignWe included all individuals aged ≥35 years resident in Sweden from 2001 to 2011. Individual-level data was retrieved from the Swedi

Short presentation of Swedish-German filmmaker Peter Weiss (1916 - 1982) and his films in connection with a new streaming service from the Filmform foundation

Aging is characterized by increased reactive species, leading to redox imbalance, oxidative damage, and senescence. The adverse effects of alcohol consumption potentiate aging-associated alterations, promoting several diseases, including liver diseases. Nucleoredoxin (NXN) is a redox-sensitive enzyme that targets reactive oxygen species and regulates key cellular processes through redox protein–pr

Background: Histological grade is a well-known prognostic factor that is routinely assessed in breast tumours. However, manual assessment of Nottingham Histological Grade (NHG) has high inter-assessor and inter-laboratory variability, causing uncertainty in grade assignments. To address this challenge, we developed and validated a three-level NHG-like deep learning-based histological grade model (

Participants judged the risk of an infection during a face to face conversation at different interpersonal distances from a SARS-CoV-2 infected person who wore a face mask or not, and in the same questionnaire answered questions about Corona related issues. Keeping a distance to an infected person serves as a protective measure against an infection. When an infected person moves closer, risk of in

The extensive exposure of the Archean continental crust in southern West Greenland makes it an important window into the tectonic evolution of early Earth. Here, we provide a comprehensive geochemical data set for tholeiitic amphibolites (meta-basalts), calc-alkaline leucoamphibolites (meta-andesites), and ultramafic rocks (meta-cumulates) for the Mesoarchean Bjørneøen Supracrustal Belt, Nuuk regi

Increasingly social activists, journalists and policy makers have expressed concern over the proliferation of conspiracy theories in the public space. There is a growing fear of their impact on social cohesion and democracy, their power to erode trust in state institutions and science. These concerns often come with an expectation that it is the responsibility of academics to engage with conspirac

Ketamine is a common anesthetic used in human and veterinary medicine. This drug has recently received increased medical and scientific attention due to its indications for neurological diseases. Despite being applied for decades, ketamine’s entire metabolism and pharmacological profile have not been elucidated yet. Therefore, insights into the metabolism and brain distribution are important towar

Aims: This study aimed to investigate the additional value of global longitudinal strain (GLS) on top of left ventricular ejection fraction (LVEF) in long-term risk prediction of combined death and heart failure (HF) re-hospitalization after acute coronary syndrome (ACS). Method and results: This retrospective study included patients admitted with ACS between 2008 and 2014 from the three participa

Background and purpose: Pyruvate dehydrogenase complex deficiency is in up to 90% caused by pathogenic variants in the X-linked PDHA1 gene. We aimed to investigate female relatives of index patients with PDHA1-related disease to (i) describe the prevalence of female PDHA1 carriers, (ii) determine whether they had symptoms and signs, and (iii) delineate the associated phenotype. Methods: In a natio