This article introduces a new method to design with older people: unfettered design. We discuss three points of concern with existing methods of involving older users: unspecific design outcomes, prejudiced views on older users, and underlying power asymmetries, which can diminish the innovative capacities of the older adults involved. To overcome these issues, we argue for the benefits of adoptin

Background and Objectives: There is a lack of understanding of how older adults' involvement and participation matters in actual design practice. This systematic literature review investigates existing empirical studies involving older users during the design of technologies and explores the nature and consequences of involving older people. Research Design and Methods: Our literature review is in

This article critically interrogates how participation is practiced during the design process. We present the findings of three different configurations of participatory design workshops, each involving a different stakeholder group (age researchers, care experts and older adults). Building on insights from Science and Technology Studies (STS), we reveal how, in design practice, different configur

Involving older people through co-design has become increasingly attractive as an approach to develop technologies for them. However, less attention has been paid to the internal dynamics and localized socio-material arrangements that enact this method in practice. In this paper, we show how the outcomes that can be achieved with user involvement often pertain to learning, but their content can di

This paper explores user involvement in company practice as a method that is both contingent and transformative. Drawing on ethnographic research in a small- to medium-sized care technology company, we trace how user involvement is enacted in diverse forms to resolve, deal with, and circumvent the frictions and tensions surrounding it. While encompassing similar types of configuration work, these

Un-doped and Cr-doped WC-10 vol% Co cemented carbides with a WC grain size of 1.4 μm have been investigated before and after hot compressive creep tests under an applied load of 900 MPa at 1000 °C and 300 MPa at 1100 °C. The Cr-doped material showed a much higher creep resistance at 1000 °C and a somewhat higher creep resistance at 1100 °C than the un-doped material. Quantitative microscopy showed

Background: Out-of-hospital cardiac arrest (OHCA) affects over 300,000 individuals per year in the United States with poor survival rates overall. A remarkable 5-fold difference in survival-to-hospital discharge rates exist across United States communities. Methods: We conducted a study using qualitative research methods comparing the system of care across sites in Michigan communities with varyin

The development of monoclonal antibody therapies targeting specific components of the pathways relevant to asthma pathophysiology has revolutionized treatment of severe asthma both in adults and children and helped to further unravel the heterogeneity of this disease. However, the availability of multiple agents, often with overlapping eligibility criteria, creates a need for pragmatic guidance fo

Background: Associations between different cancer types are known. The affirmation of the risk for non-ovarian cancer after ovarian borderline tumors (BOT) is, however, sparse. Aim: To analyze the risk of subsequent or simultaneous cancers in women with BOTs compared with the general female Swedish population. Methods: An open cohort study (1995–2018) was conducted where a diagnosis of BOTs as wel

We present a microchannel-based adaption of density-gradient centrifugation that allows the instantaneous, precise, and repeatable generation of a 1-dimensional mass-density gradient and determination of single-cell densities with integrated mass-density calibration.

Background: Gene expression (GEX) signatures in breast cancer provide prognostic information, but little is known about their predictive value for tamoxifen treatment. We examined the tamoxifen-predictive value and prognostic effects of different GEX signatures in premenopausal women with early breast cancer. Methods: RNA from formalin-fixed paraffin-embedded tumor tissue from premenopausal women

This study aims to compare two methods for the identification of anatomical and mechanical motor unit (MU) properties through the integration of high-density surface electromyography (HDsEMG) and ultrafast ultrasound (UUS). The two approaches rely on a combined analysis of the firing pattern of active MUs, identified from HDsEMG, and tissue velocity sequences of the muscle cross-section, obtained

The availability of broadband extreme ultraviolet light sources allows for investigation of electron wave-packets from high lying bound states in atoms [1,2]. The dynamics of these states can be mapped out in the ionization continuum with an overlapping infrared field, which may also uncover new, light induced, dressed states [3]. Here, we carry out a complete characterization of these electron wa

Conducting cellulose composites are promising sustainable functional materials that have found application in energy devices, sensing and water purification. Herein, conducting aerogels are fabricated based on nanofibrillated cellulose and poly(3,4-ethylenedioxythiophene) polystyrene sulfonate, using the ice templating technique, and their bulk morphology is characterized with X-ray microtomograph

Background: Accurate blood type data are essential for blood bank management, but due to costs, few of 43 blood group systems are routinely determined in Danish blood banks. However, a more comprehensive dataset of blood types is useful in scenarios such as rare blood type allocation. We aimed to investigate the viability and accuracy of predicting blood types by leveraging an existing dataset of

Whereas studies of the V1 cortex have focused mainly on neural line orientation preference, color inputs are also known to have a strong presence among these neurons. Individual neurons typically respond to multiple colors and nearby neurons have different combinations of preferred color inputs. However, the computations performed by V1 neurons on such color inputs have not been extensively studie

Body-focused repetitive behavior disorders, including trichotillomania (hair-pulling disorder) and excoriation (skin picking) disorder, typically emerge in early adolescence, but little is known about the clinical characteristics and treatment outcomes of these disorders in young people, particularly in real-world clinical settings. Participants were 63 children and adolescents (51 girls; age rang

In many democratic societies, research has identified an increase in animosity between supporters of different political parties. While this phenomenon has been extensively examined among the general public, less research has explored the role of political elites in contributing to partisan hostility. This study aims to fill this research gap by analyzing instances where members of parliament (MPs