The identification of specific biomarkers will improve the early diagnosis of disease, facilitate the development of targeted therapies, and provide an accurate method to monitor treatment response. A major challenge in the process of verifying biomarker candidates in blood plasma is the complexity and high dynamic range of proteins. This article reviews the current, targeted proteomic strategies

Why are female children still at risk in India despite progress in education, increasing participation of women in economic and political activities, and an overall improvement in the status of women? Is there any significant shift from 'son preference' to 'daughter discrimination'? Based on a study of two villages from low-fertility regions of Karnataka and Tamil Nadu, this paper attempts to unde

A new polynomial formulation of variable step size linear multistep methods is presented, where each k-step method is characterized by a fixed set of k-1 or k parameters. This construction includes all methods of maximal order (p=k for stiff, and p=k+1 for nonstiff problems). Supporting time step adaptivity by construction, the new formulation is not based on extending classical fixed step size me

Spatial distribution of sponge species richness (SSR) and its relationship with environment are important for marine ecosystem management, but they are either unavailable or unknown. Hence we applied random forest (RF), generalised linear model (GLM) and their hybrid methods with geostatistical techniques to SSR data by addressing relevant issues with variable selection and model selection. It was

Background: Preterm birth is known to constitute the major risk factor for development of germinal matrix-intraventricular hemorrhage (GM-IVH). Head position may affect cerebral hemodynamics and thus may be involved indirectly in development of GM-IVH. Turning the head toward one side may functionally occlude jugular venous drainage on the ipsilateral side while increasing intracranial pressure an

Skogar täcker ca 31% av jordens landyta och lagrar stora mängder kol i biomassa och i marken. I klimatavtalet från Paris 2015 lyfts skogars roll som sänkor och reservoarer av kol fram och undertecknande länder uppmanas att implementera strategier för hållbart skogsbruk som ytterligare förstärker skogars roll som sänkor av växthusgaser. Ett aktivt skogsbruk påverkar klimat och miljö på många olika Forest ecosystems cover 31% of the terrestrial land area and store large amounts of carbon in biomass and in soils. The 2015 Paris Agreement recognizes the importance of sinks and reservoirs of greenhouse gases (GHGs) in forests and the importance of enhancing them through sustainable forest management policies. Managing forests for climate mitigation purposes is, however, complex since management

This paper examines the short-term effect between take-up of Social Assistance Benefit (SAB) and mental health. Using a panel dataset including rich yearly register data on e.g. income, income sources, unemployment and types of pharmaceutical consumption for over 140,000 Swedes 2006-2012, we quantify the importance of the psychosocial dimensions (e.g. shame and guilt) of the socioeconomic status –

Lucky Jim, 1954, by Kingsley Amis, is considered by everyone an extremely funny academic novel; a novel of the genre. A third millennium close reading may uncover, however, side-meanings at the time of publication which, in the meantime, have become central meanings. The humoristic ingredient of the novel has dwindled dramatically, whereas the underestimated conflict between modernist rituals and

The purpose of this study was to explore retina-intrinsic neuroinflammatory reactions, effects on neuronal survival, relationship with classic gliosis, and possible role of the toll-like receptor 4 (TLR4). To isolate the adult retina from the systemic immune system, a previously described large animal explant culture model was used in which full-thickness porcine retinal sheets can be kept in vitr

AIM: To examine the psychometric properties of a modified version of the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE), for a cardiac arrest population (IQCODE-CA).METHODS: The IQCODE-CA, a 26-item observer-reported questionnaire, was completed by informants, defined as relatives or close friends, of 268 out-of-hospital cardiac arrest (OHCA) survivors who participated in the

This article seeks to explain what policy approaches and policy measures are best suited for promoting new regional industrial path development and what needs and possibilities there are for such policy to change and adapt to new conditions in order to remain efficient. The article departs from the notion of Smart Specialization and discusses how regional strategies that are inspired by this appro

We present a nonresonant circular polarization selective structure (CPSS) based on multiple layers of stacked meander line sheets arranged closely after each other. The structure has a total thickness of 13.5 mm (0.68 wavelengths at center frequency 15 GHz) and is realized by cascading printed circuit boards interspaced with a low-permittivity foam material, and the different layers are bonded tog