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Optimization of integrated chromatography sequences for purification of biopharmaceuticals

With continued development of integrated and continuous downstream purification processes, tuning and optimization become increasingly complicated with additional parameters and codependent variables over the sequence. This article offers a novel perspective of nonlinear optimization of integrated sequences with regard to individual column sizes, flow rates, and scheduling. The problem setup itsel

Predicted Heat Strain (PHS) model and the sweat loss in an extremely hot climate

Introduction: The aim was to study if the evaporative water loss can be predicted enough accurately for hydration recommendations by ISO 7933 – Predicted Heat Strain (PHS) model during a student laboratory exercise in an extremely hot environment.Method: Twelve young healthy students (8 males and 4 females), unacclimatized to heat, were exposed in a climatic chamber at 50˚C, 30% relative humidity

Higher education and competence provision in the museum sector

Museums face rapidly developing digital technologies and communication, increasingly diverse societies and audience groups, and economic restraints paired with accountability demands. This calls for new competence at museums. Yet, this area is poorly researched. This paper explores competence needs and competence management practices in museums as well as the role of higher education in relation t

Competence management in museums

Museums face increasingly complex demands in terms of increasingly diverse audiences, the rapid digital development, and demands on increased collaboration in order to achieve their organisational goals, while resources remain limited. This means that competence management and strategic development of museum organisations and services is ever more important. Yet, there is hardly any empirical rese

Platelet increment is not associated with endothelial damage in haematological patients : a prospective observational study

The aim of this study was to investigate if thrombocytopenic haematology patients show signs of endothelial damage when transfused with platelets and if that damage correlates with platelet increment measured with corrected count increment (CCI). Endothelial damage secondary to radiation or chemotherapy may lead to consumption of transfused platelets but research in this field is scarce. Patients

Comparison of different clothing area factor (fcl) calculations based on picture analysis in Adobe Photoshop : To calculate the intrinsic insulation (Icl)

Introduction: Clothing area factor (fcl) is an indicator of the increase in surface area relative to the nude body for calculation of heat loss from the clothed body to the environment. The aim was to calculate and compare the fcl values from two equations by the photographic method.Method: Thirty-five modern western indoor clothing sets (19 male and 16 female) were tested on a thermal manikin Tor

Modeling the assembly of oppositely charged lock- and key-colloids

The interaction of oppositely charged lock- and key-colloids is investigated using computer simulations. We show that indented spheres, i.e., lock-particles, can be specifically assembled with spherical key-particles using solely electrostatic interactions in addition to a hard overlap potential. An analytic description of the entropic and energetic contributions is derived and supported by simula

Extraction with Water-in-Carbon Dioxide Microemulsions : A Case Study on Steviol Glycosides

This work explores the use of water-in-supercritical carbon dioxide (scCO2) microemulsions for the extraction of polar metabolites from plants. Stevia rebaudiana Bertoni leaves and polyethylene glycol trimethylnonyl ether (TMN) surfactants were selected for a case study. A CO2-water-TMN 10 mixture at 35 °C and 30.0 MPa extracted 7 mg target analyte/g dry leaves. The extraction was proven to occur

The pleiotropic role of proteoglycans in extracellular vesicle mediated communication in the tumor microenvironment

Compartmental exchange between cells through extracellular vesicles (EVs), including exosomes and microvesicles, has emerged as a central mechanism that coordinates the complex communication between malignant and stromal cells during tumor initiation and evolution. Some of the most critical processes of EV-mediated communication, including EV biogenesis and EV uptake, can be mediated by heparan su

Combined protein A imprinting and cryogelation for production of spherical affinity material

Cryogels have been demonstrated to be efficient when applied for protein isolation. Owing to their macroporous structure, cryogels can also be used for treating particle-containing material, e.g. cell homogenates. Another challenging development in protein purification technology is the use of molecularly imprinted polymers (MIPs). These MIPs are robust and can be used repeatedly. The paper presen

Digital welfare for children in China : Human needs and sustainability

This article examines the potential of digital welfare policies and practices to enhance the wellbeing of children in China, and the congruencies and contradictions of such policies with sustainable welfare. Can child welfare be supported digitally in ways that are not environmentally destructive? The rapidly diffusing concepts of digital welfare and sustainable welfare are presented, emphasising

To Reform or to Retain? Politicians’ Incentives to Clean Up Corrupt Courts in Hybrid Regimes

This article offers a novel take on the problem of judicial independence in nondemocracies. Some scholars hold that political fragmentation leads to more judicial independence; others argue that it leads to less independence in nondemocracies. These studies have focused on judicial politicization and neglected judicial corruption. Using a process-tracing controlled comparison of reforms in Georgia

Self-healing photo-neuropathy and cervical spinal arthrosis in four sisters with brachioradial pruritus.

The cause of brachioradial pruritus (a localized itching on the arms or shoulders) is controversial. The role of sun and cervical spine disease has been discussed. This is a report on four sisters suffering from brachioradial pruritus recurring every summer. The sisters spent much time outdoors and exposed themselves extensively to the sun. They also had occupations requiring heavy lifting. Cervic

Dual effects of CGRP-antagonist on allergic contact dermatitis in human skin.

There is increasing evidence of an interaction between the nervous and the immune systems. The aim of this study was to investigate the rôle of calcitonin gene-related peptide (CGRP) in the modulation of the elicitation of immediate and delayed, immunological and non-immunological reactions in human skin. CGRP (13 pmol and 39 pmol), and the CGRP-antagonist, CGRP/8-37/, (50 pmol and 500 pmol) were

The structure and radiative lifetimes of negative ions homologous to N-

Negative ions homologous to N- are interesting systems, since there are several bound terms within the ground configuration. The forbidden transitions between them, often dominated by the magnetic dipole contributions, are affected by term mixing - a relativistic effect. When increasing the nuclear charge in the homologous sequence of negative ions, this effect increases. In this paper we use syst