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Massive bird migration across continents and seas is one of the most spectacular phenomena in nature, involving billions of birds annually. In the autumn, most birds on migration are juveniles migrating for the first time while adults are repeating their migrations. Migration syndrome in individual bird migrants involves multiple behavioural, morphological and physiological adaptations, and migrat

Pulmonary vasodilator therapy is still often an off-label treatment for pulmonary hypertension in children. The aim of this nationwide register-based study was to assess patient characteristics and strategies for pulmonary vasodilator therapy in young Swedish children. Prescription information for all children below seven years of age at treatment initiation, between 2007 and 2017, was retrieved f

Background: Nail psoriasis (NP) is common and of high importance in patients with psoriasis. Complete resolution of NP at week 24‒26 is an unambiguous nail outcome accessible for indirect treatment comparison of biologics. Objective: To evaluate the comparative efficacy of approved biologics in achieving complete resolution of NP at week 24‒26. Methods: A network meta-analysis (NMA) was conducted

Anaplastic thyroid carcinoma (ATC) is a lethal malignancy characterized by poor response to conventional therapies. Whole-genome sequencing (WGS) analyses of this tumor type are limited, and we therefore interrogated eight ATCs using WGS and RNA sequencing. Five out of eight cases (63%) displayed cyclin-dependent kinase inhibitor 2A (CDKN2A) abnormalities, either copy number loss (n = 4) or trunca

Purpose: Biological and/or physical assays for retrospective dosimetry are valuable tools to recover the exposure situation and to aid medical decision making. To further validate and improve such biological and physical assays, in 2019, EURADOS Working Group 10 and RENEB performed a field exercise in Lund, Sweden, to simulate various real-life exposure scenarios. Materials and methods: For the di

The UK Athena SWAN (AS) Charter was extended to Irish Higher Education Institutions (HEIs) in 2015 to provide a catalyst for change towards gender equality and to transform institutional cultures, through AS Gender Action Plans. This paper charts: the journey of Athena SWAN to Ireland; its rate of adoption by Irish HEIs; and its impact on the sector. Drawing upon the perspective and contribution o

Introduction: In mental health physiotherapy, there is a lack of research investigating the assumptions and clinical reasoning strategies of the professionals. A critical view on what is taken for granted within physiotherapy promotes professional development. Purpose: The purpose of this study was to explore and describe the essence of clinical reasoning of Austrian mental health physiotherapists

A source of indoor malodor in older buildings are chloroanisoles, a methylation from chlorophenols. Chlorophenols were commonly used in wood preservatives 50 years ago which were used to treat construction details exposed to high moisture loads. The methylation process requires a methylator in the form of fungi or bacteria in conjunction with adequate growth conditions for said fungi. The food ind

The growing understanding of the increased frequency and severity of extreme weather events due to climate change demands action. Locally, measures to adapt must be taken without knowing exactly what will happen, where it will happen or what the consequences will be. To meet this need, a number of decision support tools have been developed and this article investigates how municipalities can imple

Mantle cell lymphoma (MCL) is an aggressive B-cell neoplasm that follows a heterogeneous clinical course. Recurrent mutations have been described, but their applicability in the clinical setting is currently limited. The main reasons are challenges in the sequencing of DNA retrieved from formalin-fixed tissue commonly used for tissue collection in clinical biobanks. In this study, we sequenced 77

In recent years, climate change has been widely recognized as a potential problem. The building industry is taking a variety of actions towards sustainable development and climate change mitigation, such as retrofitting buildings. More than mitigation, it is important to account for climate change adaptation and investigate the probable risks and limits for mitigation strategies. For example, one

The effects of quarl on the non-premixed swirling flames were studied by performing simultaneous OH-PLIF/PIV measurements experimentally and coupling LES with PDF combustion model numerically. The results showed that LES-PDF method can successfully capture the swirl flow fields and flame structures even including local extinction and re-stabilization. Compared to the no quarl case, the quarl plays

It is well-known that the morphology of urban areas modifies the variations of climate variables at microscale; known as microclimate conditions. The complexity of urban morphology can lead to undesired wind conditions or excessive air temperature; particularly in extreme weather conditions. This study attempts to quantify the impacts of urban morphology on the evolution of wind speed and air temp

Metastatic castration-resistant prostate cancer is today incurable. Conventional imaging methods have limited detection, affecting their ability to give an accurate outcome prognosis, and current therapies for metastatic prostate cancer are insufficient. This inevitably leads to patients relapsing with castration-resistant prostate cancer. Targeting prostate-specific antigens whose expression is c

Context: In a recent study a pattern of 27 metabolites, including serum glycine, associated with bone mineral density (BMD). Objective: To investigate associations for serum and urinary glycine levels with BMD, bone microstructure, and fracture risk in men. Methods: In the population-based Osteoporotic Fractures in Men (MrOS) Sweden study (men, 69-81 years) serum glycine and BMD were measured at b

Silencing of Chl1 gene expression has been previously reported to reduce insulin secretion. Nevertheless, the mechanism underlying this effect remains unclear. In this study, we performed a serial of studies to investigate how Chl1 affects insulin secretion in INS-1 cells. RNA-sequencing was used to investigate the expression of CHL1 in human adipose, liver, muscle, and human islets. Silencing of

The seabed in the ports needs to be regularly cleaned from the marine sediments for safe navigation. Sediments contaminated by tributyltin (TBT) are environmentally harmful and require treatment before recycling. Treatment methods include leaching, stabilisation and solidification to remove toxic chemicals from the sediments and improve their strength for reuse in the construction works. This stud

Background: Early extensive surgery is a cornerstone in treatment of diffuse low-grade gliomas (DLGGs), and an additional survival benefit has been demonstrated from early radiochemotherapy in selected "high-risk"patients. Still, there are a number of controversies related to DLGG management. The objective of this multicenter population-based cohort study was to explore potential variations in dia