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Multi-tissue constrained spherical deconvolution (MT-CSD) leverages the characteristic b-value dependency of each tissue type to estimate both the apparent tissue densities and the white matter fiber orientation distribution function from diffusion MRI data. In this work, we generalize MT-CSD to tensor-valued diffusion encoding with arbitrary b-tensor shapes. This enables the use of data encoded w
Background: Active compression-decompression cardiopulmonary resuscitation (ACD-CPR) utilises a suction cup to lift the chest-wall actively during the decompression phase (AD). We hypothesised that mechanical ACD-CPR (Intervention), with AD up to 30 mm above the sternal resting position, would generate better haemodynamic results than standard mechanical CPR (Control). Methods: This out-of-hospita
This study investigates strongly nonlinear gravity waves in the compressible atmosphere from the Earth’s surface to the deep atmosphere. These waves are effectively described by Grimshaw’s dissipative modulation equations which provide the basis for finding stationary solutions such as mountain lee waves and testing their stability in an analytic fashion. Assuming energetically consistent boundary
The COVID-19 pandemic has shed light on abundant racial and ethnic health disparities in many countries around the world. In Sweden, statistics on COVID-19 mortality and morbidity from both the first and the second wave of the pandemic show that foreign-born individuals have been disproportionately affected as compared to Swedish-born individuals. However, as demonstrated in this article, key stak
Importance: Tau positron emission tomography (PET) tracers have proven useful for the differential diagnosis of dementia, but their utility for predicting cognitive change is unclear. Objective: To examine the prognostic accuracy of baseline fluorine 18 (18F)-flortaucipir and [18F]RO948 (tau) PET in individuals across the Alzheimer disease (AD) clinical spectrum and to perform a head-to-head compa
Background: Transient tachypnea of the newborn (TTN) is caused by delayed clearance of lung fluid at birth. TTN typically appears within the first two hours of life in term and late preterm neonates and is characterized by tachypnea and signs of respiratory distress. Although it is usually a self-limited condition, admission to a neonatal unit is frequently required for monitoring and providing re
Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To determine the effects of pharmacological interventions for pain and sedation management in newborn infants undergoing therapeutic hypothermia.
Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To assess the benefits and harms of interventions in non-healthcare-related workplaces to reduce the risk of SARS-CoV-2 infection relative to other interventions or no intervention.
Selective ERα modulator, tamoxifen, is well tolerated in a heavily pretreated castration-resistant prostate cancer (PCa) patient cohort. However, its targeted gene network and whether expression of intratumor ERα due to androgen deprivation therapy (ADT) may play a role in PCa progression is unknown. In this study, we examined the inhibitory effect of tamoxifen on castration-resistant PCa in vitro
Methane emissions from boreal and arctic wetlands, lakes, and rivers are expected to increase in response to warming and associated permafrost thaw. However, the lack of appropriate land cover datasets for scaling field-measured methane emissions to circumpolar scales has contributed to a large uncertainty for our understanding of present-day and future methane emissions. Here we present the Borea
Objective: The Systemic Lupus International Collaborating Clinics (SLICC) 2012 systemic lupus erythematosus (SLE) classification criteria and the revised American College of Rheumatology (ACR) 1997 criteria are list based, counting each SLE manifestation equally. We derived a classification rule based on giving variable weights to the SLICC criteria and compared its performance to the revised ACR
Objective: Opioids have long been prescribed for chronic pain conditions, including osteoarthritis (OA). However, there is little information about their temporal efficacy, or differences in efficacy and safety between opioids with strong versus weak/intermediate μ opioid receptor–binding affinity. To explore these research questions, we conducted a systematic review and meta-analyses of randomize
Objective: To explore whether magnetic resonance imaging (MRI) features suggestive of knee osteoarthritis (OA) are associated with presence of knee pain in possible early-stage OA development. Methods: We included 294 participants from the Osteoarthritis Initiative (mean ± SD age 50 ± 3 years; 50% women) with baseline Kellgren/Lawrence grade of 0 in both knees, all of whom had received knee MRIs a
Objective: To assess the proportion of participants reconsidering their willingness to undergo surgery after 3 and 12 months. Secondary aims were to analyze and compare the characteristics of individuals willing and unwilling to undergo joint surgery for osteoarthritis (OA) before a first-line intervention, and to study the association between pain intensity, walking difficulties, self-efficacy, a
In 2019, the Swedish government officially switched terminology from using the traditional endogenous term Vitryssland to the exogenous Belarus. Vitryssland (lit: White Russia) had been in use in the Swedish language since the 17th century, and the decision was neither easy nor swift. There was no consensus about the utility of the change, and significant opposition from linguists and editors agai
Energy users who don’t participate in efficiency and conservation programmes despite ongoing outreach are often referred to as ‘Hard-to-Reach’ (HTR). These individuals or organisations can include, e.g., low income or vulnerable households; renters; and small businesses. More effectively engaging HTR audiences is key to ensuring everyone benefits equitably from low-carbon energy transitions and re
In active volcanic regions, high-temperature chemical reactions in the hydrothermal system consume CO2 sourced from magma or from the deep crust, whereas reactions with silicates at shallow depths mainly consume atmospheric CO2. Numerous studies have quantified the load of dissolved solids in rivers that drain volcanic regions to determine chemical weathering rates and atmospheric CO2 consumption
An comprovisation on the concrete/visual poem "Meditation no. 1" by Emmett Williams.
An comprovisation on the concrete/visual poem "Frictional (Phonetical Etude no. 2" by Jaap Blonk.
