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Background: Gene duplication has led to a most remarkable adaptation involved in vertebrates' host-pathogen arms-race, the major histocompatibility complex (MHC). However, MHC duplication history is as yet poorly understood in non-mammalian vertebrates, including birds. Results: Here, we provide evidence for the evolution of two ancient avian MHC class IIB (MHCIIB) lineages by a duplication event
We propose a general approach to describe spreading widths of monopole, dipole, and quadrupole giant resonances in heavy and superheavy spherical nuclei. Our approach is based on the ideas of the random matrix distribution of the coupling between one-phonon and two-phonon states generated in the random-phase approximation. We use the Skyrme interaction SLy4 as our model Hamiltonian to create a sin
The production of K∗(892)0 and φ(1020) mesons in proton-proton (pp) and lead-lead (Pb-Pb) collisions at sNN=2.76TeV has been analyzed using a high luminosity data sample accumulated in 2011 with the ALICE detector at the Large Hadron Collider (LHC). Transverse momentum (pT) spectra have been measured for K∗(892)0 and φ(1020) mesons via their hadronic decay channels for pT up to 20GeV/c. The measur
Personal data is found at the core of the digital economy, and from a consumer perspective it is increasingly difficult to assess when it's collected, how it is utilised or traded and by what third parties it is handled over time. As Rhoen (2016) argues, a broader application of consumer protection regulation to user agreements may increase accountability for operators who collect and manage perso
Tyrosine kinase inhibitors targeting the BCR-ABL oncoprotein in chronic myeloid leukemia (CML) are remarkably effective inducing deep molecular remission in most patients. However, they are less effective to eradicate the leukemic stem cells (LSC), resulting in disease persistence. Therefore, there is great need to develop novel therapeutic strategies to specifically target the LSC. In an experime
Student engagement is an important factor when it comes to the learning process. Students who do not feel engaged in their studies are more likely to fail their exams and might even drop out of their education. Different methods have been tried in order to increase student engagement. One of them is the contributing student pedagogy, where students contribute to the learning of others and also val
Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide. Cyclooxygenase-2, which plays a key role in the biosynthesis of prostaglandin E2 (PGE2), is often up-regulated in CRC and in other types of cancer. PGE2 induces angiogenesis and tumor cell survival, proliferation and migration. The tumor suppressor 15-hydroxyprostaglandin dehydrogenase (15-PGDH) is a key enzym
BACKGROUND: Animal agriculture has been criticised in terms of its sustainability from several perspectives. Ruminants such as dairy cows can transform inedible, low-quality protein in roughage and by-products from the food industry into the high-quality protein found in milk and meat. Evaluation of the protein conversion efficiency of dairy production from a sustainability and resource perspectiv
A measurement of the calorimeter response to isolated charged hadrons in the ATLAS detector at the LHC is presented. This measurement is performed with 3.2 nb- 1 of proton–proton collision data at s=7 TeV from 2010 and 0.1 nb- 1 of data at s=8 TeV from 2012. A number of aspects of the calorimeter response to isolated hadrons are explored. After accounting for energy deposited by neutral particles,
These guidelines for endoscopic surveillance after colorectal polypectomy are based on the recommendations published by European Society of Gastrointestinal Endoscopy (ESGE) in 2013. A precondition for the guidelines is that patients have undergone a high-quality colonoscopy, including complete removal and histopathological evaluation of all detected neoplastic lesions. Current research has made i
Several aspects describing the state of the atmosphere in the North Sea region are considered in this chapter. These include large-scale circulation, means and extremes in temperature and precipitation, cyclones and winds, and radiation and clouds. The climate projections reveal several pronounced future changes in the state of the atmosphere in the North Sea region, both in the free atmosphere an
Type of Study: This is a longitudinal, case-control clinical trial. Objectives: This study aims to track recovery time following a vocal loading task (VLT) imposing vocal fatigue and to explore if patients with functional dysphonia (FD) are worse affected by vocal loading, and if these patients take longer than others to recover. Methods: Fifty (n = 50) female participants in four vocal subgroups
Bär är nyttiga och har hög näringstäthet i förhållande till mängden energi. Bär är även rika på polyfenoler som ger bären deras karakteristiska smak och färg. Polyfenolrika dieter har visats kunna skydda mot utveckling av vissa sjukdomar, till exempel typ 2-diabetes, men mekanismerna bakom de observerade effekterna är inte klarlagda. Flera olika mekanismer har föreslagits och involverar bland anna
Recension av Stefan Arvidsson, Morgonrodnad. Socialismens stil och mytologi 1871–1914.
Recension av Hannah Arendt, Totalitarismens ursprung
Recension av Fredric Bedoire, Turist på 1800-talet. Bilder från de första tågresenärerna
Recension av Karin L. Eriksson (red.), Möten med mening. Ämnesdidaktiska fallstudier i konst och humaniora
