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Ionizable lipids such as the promising Dlin-MC3-DMA (MC3) are essential for the successful design of lipid nanoparticles (LNPs) as drug delivery agents. Combining molecular dynamics simulations with experimental data, such as neutron reflectivity experiments and other scattering techniques, is essential to provide insights into the internal structure of LNPs, which is not fully understood to date.

Objective: The association between mammographic density (MD) and breast cancer (BC) recurrence and survival remains unclear. Patients receiving neoadjuvant chemotherapy (NACT) are in a vulnerable situation with the tumor within the breast during treatment. This study evaluated the association between MD and recurrence/survival in BC patients treated with NACT. Methods: Patients with BC treated wit

Kort historisk betraktelse över domkyrkan som lokal för universitetets promotioner med fokus dels på inslaget av anspelningar på antik mytologi, dels på varför promotionerna under ett drygt halvsekel flyttades till andra lokaler.

Background: Collegial midwifery assistance during the active second stage of labor that involves a second midwife being present has been shown to reduce severe perineal trauma (SPT) by 30%. The aim of this study was to investigate primary midwives' experiences of collegial midwifery assistance with the purpose of preventing SPT during the active second stage of labor. Methods: This study uses an o

INTRODUCTION: Very preterm birth is associated with lung function impairment later in life, but several aspects have not been studied. We aimed to comprehensively assess lung function at school age in very preterm infants and term controls, with special emphasis on bronchopulmonary dysplasia (BPD), sex, and bronchodilator response.METHODS: At 12 years of age, 136 children born very preterm (85 wit

BACKGROUND: Preterm birth is the leading cause of neonatal mortality and morbidity. Early diagnosis and interventions are critical to improving the clinical outcomes of extremely premature infants. Blood protein profiling during the first months of life in preterm infants can shed light on the role of early extrauterine development and provide an increased understanding of maturation after extreme

Det har nu gått snart tio år sedan det uppdagades att dricksvattnet i ett av vattenverken i Ronneby, som försörjde 1/3 av hushållen med dricksvatten, var mycket kraftigt förorenat av PFAS. Visserligen kunde rent vatten omedelbart kopplas in i vattenledningsnätet, men alla som under lång tid druckit det förorenade vattnet har fortfarande förhöjda halter av PFAS i kroppen och kommer att fortsätta ha

Indoor radon represents a health hazard for occupants. However, the indoor radon measurement rate is low in Sweden because of no mandatory requirements. Measuring indoor radon on an urban scale is complicated, machine learning exploiting existing data for pattern identification provides a cost-efficient approach to estimate indoor radon exposure in the building stock. Extreme gradient boosting (XG

Det rapporteras många fall och spenderas årligen stora mängder av resurser på vattenskador i byggnader i Sverige. Vattenskador som uppkommer på grund av läckage och utströmning av vatten från installationer så som tappvatten-, avlopp- och värmesystem, utrustning så som kylskåp, frysar och diskmaskiner samt läckande tätskikt i våtrum. Vattenskador från dessa system orsakar allvarliga problem i byggA large amount of water damage cases and resources are annually reported and spent on water damage in Sweden from cases occurring in buildings from building services such as tap water-, sewage, heating systems, household appliances such as refrigerators, freezers and dishwashers and inadequate waterproof membranes in wet rooms. These water damage cases in buildings cause several problems in the bu

Being the second leading cause of death and the leading cause of disability-adjusted life years worldwide, infectious diseases remain─contrary to earlier predictions─a major consideration for the public health of the 21st century. Resistance development of microbes to antimicrobial drugs constitutes a large part of this devastating problem. The most widely spread mechanism of bacterial resistance

Carbapenem resistance caused by metallo-β-lactamases is a serious global challenge that, if not tackled efficiently, is expected to lead to millions of deaths in the coming decades. Verona-integron encoded metallo-β-lactamase 2 (VIM-2) is a bacterial enzyme that has been reported from multidrug-resistant nosocomial isolates of Pseudomonas aeruginosa and other Gram-negative pathogens. As it hydroly

Under andra världskriget fälldes tusentals ton bomber mot både militära och civila mål på marken. Förlusterna var stora såväl vad gäller antal nedskjuta bombplan och omkomna besättningsmän på dessa plan som de som blev offer för bombraiderna. Historien om bombkriget sträcker sig längre tillbaka än andra världskriget, men under åren 1939–45 förändrades förutsättningarna. Bombplanen kunde medföra al