BACKGROUND: The Symphony study compared four immunosuppressant regimens, defined by protocol-specified target drug concentrations. This subanalysis examines actual drug levels and the implications on the interpretation of results. METHODS: De novo renal transplant patients (n=1645) were randomized to receive mycophenolate mofetil (2 g/day) and corticosteroids in combination with standard-dose cycl

We have previously proposed the use of Doppler ultrasound to non-invasively stage sinus infection, as we showed that acoustic streaming could be generated in nonpurulent sinus secretions and helped to distinguish it from mucopurulent sinus secretions. In order to continue this development of a clinically applicable Doppler equipment, we need to determine different dimensions of the paranasal sinus

As counter intuitive as it might sound, autocracy without elections is a rare combination today. Elections do not constitute democracy, but they can promote democratization. This dissertation studies the process of democratization through elections, focusing on the effect of opposition coordination. Several authors have stressed the importance of opposition coordination as an explanation for democ

The authors present a custom chip for use in digital predistortion linearisation of RF power amplifiers. The chip is mainly implemented with systolic arrays. At maximum clock-rate, 130 MHz, the throughput is 16 Msamples/s with a 5 V supply voltage and power consumption of 1 W. A throughput of 2 Msamples/s is achieved at a 1.2 V supply voltage with 6 mW power consumption

To describe the home environment in terms of housing conditions and their association with child health in a disadvantaged immigrant population.

Due to its significant applicability for early detection, risk prediction and follow-up evaluation, prostate specific antigen (PSA) has revolutionized our ability to treat prostate cancer patients. With the prevalent use of PSA for early detection during the last two decades, disease characteristics have been altered towards early detected, localized tumors with a high chance of cure following loc

POU5F1, which encodes a transcriptional factor, has two alternatively spliced transcripts, 1 and 2, as well as six pseudogenes. Transcript 1 is considered to be a key regulator of cellular pluripotency and self-renewal. The POU5F1 pseudogene, POU5F1P1 on 8q24, encodes a protein with 95% homology with the isoform 1 of POU5F1. It is located 15 kbp downstream of the SNP rs6983267, which is strongly a

Background Preventive measures are needed to counteract the increasing burden of cutaneous malignant melanoma (CMM). As a basis for rational melanoma prevention, we investigated geographic differences and impact from socioeconomic factors related to incidence, clinical stage at diagnosis and outcome. Material and methods All patients with primary invasive CMM diagnosed in 2004-2013 in the southern