Sökresultat

Filtyp

Din sökning på "*" gav 529953 sökträffar

Monoclonal gammopathy of undetermined significance and risk of skeletal fractures: a population-based study

Patients with multiple myeloma (MM) have an increased risk of fractures. On the basis of small numbers, patients with monoclonal gammopathy of undetermined significance (MGUS) have been reported to have an increased fracture risk. Using population-based data from Sweden, we assessed the risks of fractures in 5326 MGUS patients diagnosed from 1958 to 2006, compared with 20 161 matched controls. MGU

Amelioration of Experimental Autoimmune Encephalomyelitis by the Quinoline-3-Carboxamide Paquinimod (ABR-215757): Reduced Priming of Proinflammatory Effector CD4(+) T Cells.

Quinoline-3-carboxamide compounds (Q compounds) have demonstrated efficacy in treating autoimmune disease in both humans and mice. However, the mode of action of these compounds is poorly understood. Here, we show that preventive treatment with the Q compound paquinimod (ABR-215757) during the first 5 days after induction of experimental autoimmune encephalomyelitis is sufficient to significantly

Quantifying the Family Frailty Effect in Infant and Child Mortality by Using Median Hazard Ratio (MHR)

Most microlevel studies in the social sciences have focused on the impact of different measured variables. While some studies have also dealt with unobserved variation, it has usually only been controlled for to perfect the estimates of the observables. In this article, the authors applied a modified version of a recently developed method designed to quantify the effect of unobserved variation in

The impact of catch-and-release on the foraging behaviour of pike (Esox lucius) when released alone or into groups

A commonly practiced method intended to reduce mortality from recreational fisheries is mandatory (e.g., small fish protected by minimum-size limits) or voluntary catch-and-release (C&R), where fish are caught with hook and line and released alive on the assumption that fish survive unharmed. C&R can, however, have both lethal and sub-lethal consequences for fish, with altered behaviour se

The Influence of Sea Waves on Offshore Wind Turbine Aerodynamics

The impacts of swells on the atmospheric boundary layer (ABL) flows and by this on the standalone offshore wind turbine (WT) performance are investigated by using large eddy simulations (LES) and actuator-line techniques. At high swell to wind speed ratio, the swell-induced stress reduces the total wind stress resulting in higher wind velocity, less wind shear, and lower turbulence intensity level

Accelerating crystal plasticity simulations using GPU multiprocessors

Crystal plasticity models are often used to model the deformation behavior of polycrystalline materials. One major drawback with such models is that they are computationally very demanding. Adopting the common Taylor assumption requires calculation of the response of several hundreds of individual grains to obtain the stress in a single integration point in the overlying FEM structure. However, a

Moving beyond short-term coping and adaptation

Throughout human history, people have coped with, and adapted to, their environment. This accumulated capacity at local level is increasingly recognized to be critical in improving resilience and transformation. Nevertheless, city dwellers’ coping and adaptive practices are little known, poorly documented and often not taken into account in the work of municipal authorities and aid organizations.

Impact of cardiac dysfunction on health-related quality of life in cirrhotic liver transplant candidates

Objective Cardiac dysfunction, in particular left ventricular diastolic dysfunction, is common in cirrhosis. We aimed to investigate the impact of cardiac dysfunction on health-related quality of life (QoL) in liver cirrhosis. Materials and methods A total of 88 cirrhotic liver transplant candidates with an available echocardiogram and ECG completed the Short form-36 (SF-36) and Fatigue Impact Sca

Smoking and the risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition

Background: Smoking is not associated with prostate cancer incidence in most studies, but associations between smoking and fatal prostate cancer have been reported. Methods: During 1992 and 2000, lifestyle information was assessed via questionnaires and personal interview in a cohort of 145112 European men. Until 2009, 4623 incident cases of prostate cancer were identified, including 1517 cases of

Increased risk of cirrhosis and hepatocellular cancer during long-term follow-up of patients with biopsy-proven NAFLD.

Abstract Objective. Our aims were to investigate the natural history of biopsy-proven non-alcoholic fatty liver disease (NAFLD) in Sweden, its associated complications, the clinical and biochemical factors associated with more advanced liver disease and the survival rate with a mean follow-up time of 27 years. Material and methods. All subjects participating in the population-based prospective coh

Catalytically Active Silica Nanoparticle-Based Supramolecular Architectures of Two Proteins - Cellobiose Dehydrogenase and Cytochrome c on Electrodes

Artificial nanobiomolecular architectures that follow natural examples in protein assembly become more and more important from basic and applied points of view. Our study describes the investigation on cellobiose dehydrogenase (CDH), cytochrome c (cyt c), and silica nanoparticles (SiNP's) for the construction of fully catalytically active supramolecular architectures on electrodes. We report on in

Conductance Enhancement of InAs/InP Heterostructure Nanowires by Surface Functionalization with Oligo(phenylene vinylene)s

We have investigated the electronic transport through 3 mu m long, 45 nm diameter InAs nanowires comprising a 5 nm long InP segment as electronic barrier. After assembly of 12 nm long oligo(phenylene vinylene) derivative molecules onto these InAs/InP nanowires, we observed a pronounced, nonlinear I-V characteristic with significantly increased currents of up to 1 mu A at 1 V bias, for a back-gate

Sorting cells by size, shape and deformability.

While size has been widely used as a parameter in cellular separations, in this communication we show how shape and deformability, a mainly untapped source of specificity in preparative and analytical microfluidic devices can be measured and used to separate cells.

Inactivation of promoter 1B of APC causes partial gene silencing: evidence for a significant role of the promoter in regulation and causative of familial adenomatous polyposis

Familial adenomatous polyposis (FAP) is caused by germline mutations in the adenomatous polyposis coli (APC) gene. Two promoters, 1A and 1B, have been recognized in APC, and 1B is thought to have a minor role in the regulation of the gene. We have identified a novel deletion encompassing half of this promoter in the largest family (Family 1) of the Swedish Polyposis Registry. The mutation leads to