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Transcriptional and post-transcriptional regulation of vascular smooth muscle cell phenotype - Implications for vascular disease states

As the world population is pushing toward 8 billion, cardiovascular diseases (CVD) remain the leading cause of death worldwide, representing 30% of all global deaths. A large body of work has recognized that smooth muscle cells (SMCs) surrounding the blood vessels play a prominent role in the development and progression of cardiovascular diseases. SMCs are highly specialized cells with the main fu

Informing patients on planned consultation time–a randomised controlled intervention study of consultation time in primary care

Objective: To investigate whether patients’ pre-consultation knowledge of the time frames for the consultation influences the actual consultation time and/or patient and physician related outcomes; satisfaction and enablement. Design: Randomised controlled blinded intervention study. Setting: Four strategically chosen Primary Health Care Centres (PHCC:s) in Kronoberg county in Sweden participated.

Artificial intelligence-based versus manual assessment of prostate cancer in the prostate gland : a method comparison study

Aim: To test the feasibility of a fully automated artificial intelligence-based method providing PET measures of prostate cancer (PCa). Methods: A convolutional neural network (CNN) was trained for automated measurements in 18F-choline (FCH) PET/CT scans obtained prior to radical prostatectomy (RP) in 45 patients with newly diagnosed PCa. Automated values were obtained for prostate volume, maximal

Unmet health-care needs and mortality : A prospective cohort study from southern Sweden

Aims: Research on the effect of unmet health-care needs on mortality at follow-up is scarce. This study investigated whether unmet health-care needs in 2008 were associated with a higher risk of mortality during a five-year follow-up period in a population in southern Sweden, and whether the association was stronger for particular subgroups of cause of death. Methods: The 2008 public-health survey

Controlling Urban Drainage Systems

The key issue in urban drainage (UD) systems, looking from a control engineering perspective, is operation. Measurements, feedback, control and automation are tools to address the challenges. Measurement technology combined with analysis and parameter estimation are used to obtain relevant information for decision and control. The UD control problem is truly multivariable with many sensors and act

Increased functional connectivity of thalamic subdivisions in patients with Parkinson’s disease

Parkinson’s disease (PD) affects 2–3% of the population over the age of 65 with loss of dopaminergic neurons in the substantia nigra impacting the functioning of basal ganglia-thalamocortical circuits. The precise role played by the thalamus is unknown, despite its critical role in the functioning of the cerebral cortex, and the abnormal neuronal activity of the structure in PD. Our objective was

Are crystallographic : B-factors suitable for calculating protein conformational entropy?

Conformational entropies are of great interest when studying the binding of small ligands to proteins or the interaction of proteins. Unfortunately, there are no experimental methods available to measure conformational entropies of all groups in a protein. Instead, they are normally estimated from molecular dynamics (MD) simulations, although such methods show problems with convergence and correla

A complexity perspective on logistics management : Rethinking assumptions for the sustainability era

Purpose: The purpose of this paper is to elaborate on how perspectives and assumptions embedded in the complexity paradigm contribute to make logistics management research better aligned with real-life logistics. This is necessary, due to increasing supply chain complexity caused by an increasing request for sustainable development (SD). Design/methodology/approach: The research is exploratory and

Brain measures of toddlers’ shape recognition predict language and cognitive skills at 6–7 years

While a number of studies have found that an improvement in object shape recognition is associated with language growth in infants and toddlers, no published studies have investigated the longitudinal relation between early shape recognition, and language abilities in later childhood. An electrophysiological measure of semantic processing (the N400) was used to assess shape recognition and general

Mapping EQ-5D-3L from the Knee Injury and Osteoarthritis Outcome Score (KOOS)

PURPOSE: To develop a mapping model to estimate EQ-5D-3L from the Knee Injury and Osteoarthritis Outcome Score (KOOS).METHODS: The responses to EQ-5D-3L and KOOS questionnaires (n = 40,459 observations) were obtained from the Swedish National anterior cruciate ligament (ACL) Register for patients ≥ 18 years with the knee ACL injury. We used linear regression (LR) and beta-mixture (BM) for direct m