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Morphometry of medial temporal lobe subregions using high-resolution T2-weighted MRI in ADNI3 : Why, how, and what's next?

This paper for the 20th anniversary of the Alzheimer's Disease Neuroimaging Initiative (ADNI) provides an overview of magnetic resonance imaging (MRI) of medial temporal lobe (MTL) subregions in ADNI using a dedicated high-resolution T2-weighted sequence. A review of the work that supported the inclusion of this imaging modality into ADNI Phase 3 is followed by a brief description of the ADNI MTL

How does dyslexia impact second language acquisition? : Insights from a questionnaire study with Italian and German learners of L2 English

This study compares the self-perception of first (L1) and second (L2) language competence and dyslexia awareness in two groups of dyslexic students, one German and one Italian, learning English as a second language. Based on a survey, we investigate the relationship between students’ self-perception of their L1 and L2 competence, and how perceived L1 competence, L2 learning motivation, time of dys

Reindeer grazing reduces climate-driven vegetation changes and shifts trophic interactions in the Fennoscandian tundra

Herbivores drive shifts in plant species composition by interacting with vegetation through defoliation, trampling and nutrient addition: urine and faeces. As herbivore effects on vegetation accumulate over time, they might spillover to other trophic levels, but how and when this happens is poorly understood. Since it is methodologically demanding to measure biodiversity across spatial gradients,

The CONVINCE randomized trial found positive effects on quality of life for patients with chronic kidney disease treated with hemodiafiltration

In the CONVINCE trial, the primary analysis demonstrated a survival benefit for patients receiving high-dose hemodiafiltration (HDF) as compared with high-flux hemodialysis (HD). A secondary objective was to evaluate effects on health-related quality of life (HRQoL); assessed in eight domains (physical function, cognitive function, fatigue, sleep disturbance, anxiety, depression, pain interference

Aminomethylations of electron-deficient compounds—bringing iron photoredox catalysis into play

The α-functionalisation of N-containing compounds is an area of broad interest in synthetic chemistry due to their presence in biologically active substances among others. Visible light-induced generation of nucleophilic α-aminoalkyl radicals as reactive intermediates that can be trapped by electron-deficient alkenes presents an attractive and mild approach to achieve said functionalisation. In th

Skogens klimatnytta 2.0 – Klimatomställning nästa

Det skogsbruk och den skogsnäring vi har idag har formats i en annan tid och under andra förutsättningar än de som råder nu. Hur man än ser på klimatfrågan innebär den en ny dimension som återstår att fullt ut inkorporera i bedömningar och beslut om mål och styrning, hos skogsägaren, skogsindustrin och i politiken. Vid sidan om produktionen av träråvara måste nu också klimatnyttan ses som ett mål.

The use of venous blood gas in assessing arterial acid−base and oxygenation status–an analysis of aggregated data from multiple studies evaluating the venous to arterial conversion (v-TAC) method

Background: Several methods exist to reduce the number of arterial blood gases (ABGs). One method, Roche v-TAC, has been evaluated in different patient groups. This paper aggregates data from these studies, in different patient categories using common analysis criteria. Research design and methods: We included studies evaluating v-TAC based on paired arterial and peripheral venous blood samples. B

Microheater Controlled Crystal Phase Engineering of Nanowires Using In Situ Transmission Electron Microscopy

Crystal Phase Quantum Dots (CPQDs) offer promising properties for quantum communication. How CPQDs can be formed in Au-catalyzed GaAs nanowires using different precursor flows and temperatures by in situ environmental transmission electron microscopy (ETEM) experiments is studied. A III-V gas supply system controls the precursor flow and custom-built micro electro-mechanical system (MEMS) chips wi

Fentanyl dosage for preterm infants suggested by a pharmacokinetic, -dynamic, and -genetic model

Background: Fentanyl is commonly administered for procedural pain management in preterm infants, but target concentrations have not yet been defined. Methods: To investigate pharmacokinetics (PK), -dynamics (PD), and -genetics (PG), 25 infants (gestational age 23.3–34.1 weeks) received a fentanyl dose before a skin-breaking procedure (0.5 µg/kg) or tracheal intubation (2 µg/kg). Four pain scales w

MATCHING OF AN OVERHUNG VOLUTE TO A CENTRIFUGAL COMPRESSOR AT VARIED OPERATING CONDITIONS

Centrifugal compressors are widely used in turbocharged powertrains for Heavy-Duty applications. The volute of the centrifugal compressors is generally of the overhung type. The design of volutes is often neglected, and the shape of the volute is dictated by the packaging requirements of the engine. However, with the advent of Hydrogen-based propulsion systems, the efficiency of all the components

A recurrence-type strong Borel-Cantelli lemma for Axiom A diffeomorphisms

Let (X, μ, T , d) be a metric measure-preserving dynamical system such that three-fold correlations decay exponentially for Lipschitz continuous observables. Given a sequence (Mk) that converges to 0 slowly enough, we obtain a strong dynamical Borel.Cantelli result for recurrence, that is, for μ-almost every x ∈ X, {equation presented} where μ(Bk(x)) = Mk. In particular, we show that this result h

Stakeholder participation in the implementation of urban property development projects

In urban property development projects, attention to the needs and aspirations of local communities is often neglected. Although some developers still consider local community stakeholders to be a potential threat to their developments, in many developed countries, stakeholder participation is embedded within statutory processes such as the formal planning process and is increasingly regarded as a

Surface pressure reconstruction from LPT data with boundary conforming grids

The coupling between fluid-structure interactions is governed by the pressure distribution over the interaction surface between the fluid and solid domains. The capabilities of non-intrusive optical techniques, such as particle image velocimetry and Lagrangian particle tracking (LPT), have been proven to provide accurate velocity and acceleration information within the flow field while simultaneou

Diagnostic accuracy and radiological validation of intracerebral hemorrhage diagnosis in the Swedish Stroke Register (Riksstroke)

Background and purpose: National quality registries for stroke care operate under the assumption that the included patients are correctly diagnosed. We aimed to validate the clinical diagnosis of spontaneous intracerebral hemorrhage (ICH) in Riksstroke (RS) by evaluating radiological data from a large, unselected ICH population. Methods: We conducted a retrospective, multicenter study including al

High circulating activin A plasma levels are associated with tumour stage and poor survival in treatment-naive lung squamous cell cancer patients

Objectives: Lung squamous cell carcinoma (LUSC) is associated with a poor prognosis and a lack of specific treatment options. The dysregulation of activin A (ActA) has been reported in various malignancies. Herein, we investigated the diagnostic and prognostic significance of ActA in LUSC. Materials and methods: ActA concentrations were measured using ELISA in plasma samples of 128 LUSC patients (

Do premorbid weight parameters predict BMI 30 years after adolescent-onset anorexia nervosa?

Purpose: To examine anthropometric predictors of BMI 30 years after the onset of adolescent AN. Methods: A group of 51 individuals with adolescent-onset AN were identified in Sweden in 1985. Anthropometric data have been collected from birth records and school nurse charts. A group matched for gender, school and age constituted a healthy control group. Possible predictors of BMI 30 years after AN