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Histidine oxidation in lytic polysaccharide monooxygenase

The lytic polysaccharide monooxygenases (LPMOs) comprise a super-family of copper enzymes that boost the depolymerisation of polysaccharides by oxidatively disrupting the glycosidic bonds connecting the sugar units. Industrial use of LPMOs for cellulose depolymerisation has already begun but is still far from reaching its full potential. One issue is that the LPMOs self-oxidise and thereby deactiv

Policy measures to reduce stereotypical representations of older people in long-term care

Older people are stereotypically portrayed in the media at two extremes of a spectrum, either the healthy and happy retiree, or the fragile and sick older person in need of care. Older people living in residential long-term care are particularly portrayed in a homogenous way. Individuals exposed to stereotypical portrayals could develop a distorted view of the realities of older people and later l

Tracing Sustainability in the Long Run : Genuine Savings Estimates 1850 - 2018

We introduce a new database of historical Genuine Savings (GS), an indicator of sustainable development promoted by the World Bank and widely used in contemporary economic research. GS derives from the theoretical work on wealth accounting, and addresses shortcomings in conventional metrics of economic development by incorporating broader measures of saving and investment, including human capital

What is new in type 1 diabetes? [Video file]

Topics Covered - Genetic etiology- Autoantibodies as biomarkers- Autoantibodies predict clinical onset of diabetes- TEDDY study- DIPP study- Etiology and pathogenesis of type 1 diabetes- IAA-first or GADA-first

The humans of ancient Hermione : the necropolis in the light of bioarchaeology

Bioarchaeology has the potential to substantially inform about ancient lifeways through osteological analyses of the remains of the once living individuals. This article provides insights of the demography and health of the people of ancient Hermione (Geometric-Roman period). A minimum number of 85 individuals from the Hermione necropolis was osteologically analyzed. Although the analysis was limi

Association of infant Rib and Alp1 surface protein N-terminal domain immunoglobulin G and invasive Group B Streptococcal disease in young infants

Background: Vaccine development for Group B Streptococcus (GBS), a common cause of invasive disease in early-infancy and adverse pregnancy outcomes, include exploring widely-expressed GBS surface proteins as vaccine epitopes. We investigated the association between natural infant serum IgG against the RibN and Alp1N domains and risk of invasive GBS disease caused by isolates expressing these prote

Isospin-breaking corrections to light-meson leptonic decays from lattice simulations at physical quark masses

The decreasing uncertainties in theoretical predictions and experimental measurements of several hadronic observables related to weak processes, which in many cases are now smaller than O(1%), require theoretical calculations to include subleading corrections that were neglected so far. Precise determinations of leptonic and semi-leptonic decay rates, including QED and strong isospin-breaking effe

FREE OUTER FUNCTIONS IN COMPLETE PICK SPACES

Jury and Martin establish an analogue of the classical inner-outer factorization of Hardy space functions. They show that every function f in a Hilbert function space with a normalized complete Pick reproducing kernel has a factorization of the type f = ϕg, where g is cyclic, ϕ is a contractive multiplier, and ||f|| = ||g||. In this paper we show that if the cyclic factor is assumed to be what we

Task Re-allocation in New Venture Teams : A Team Conflict Perspective

This study contributes a novel perspective on how new venture teams navigate task re-allocation during the new venture development phase. It highlights the relevance of task re-allocation conflict, shows how “negative affect expectations” shape the unfolding of such conflicts, and demonstrates why acting out conflict and its associated negative affect can enable team members to make substantial ta