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Objectives. BMD in the hand, as evaluated by digital X-ray radiogrammetry (DXR), has been suggested to be a predictor for joint damage in RA. A predictor for long-term prognosis might also predict increased mortality in RA. The aim of the present study was to evaluate BMD in the hand as a predictor for all-cause mortality. Methods. In 1978, 152 consecutive patients (78% women, mean disease duratio

Lipoblastoma is a rare benign tumor that arises from embryonic adipose tissue and usually occurs in young children. Here, we present a review of available cytogenetic data and the karyotypes of 10 new cases of lipoblastoma, of which 7 could be studied further by fluorescence in situ hybridization (FISH) with regard to the involvement of the PLAG1 gene. All seven tumors with clonal aberrations harb

Cerebral ischemia that develops after subarachnoid hemorrhage (SAH) carries high morbidity and mortality. Inflammatory mediators are involved in the development of cerebral ischemia through activation of the mitogen-activated protein kinase pathway. We hypothesized that blockade of the MAPkinase/ERK (MEK)/extracellular signal-regulated kinase (ERK) pathway upstream with a specific raf inhibitor wo

Parnetti L, Chiasserini D, Andreasson U, Ohlson M, Hüls C, Zetterberg H, Minthon L, Wallin ÅK, Andreasen N, Talesa VN, Blennow K. Changes in CSF acetyl- and butyrylcholinesterase activity after long-term treatment with AChE inhibitors in Alzheimer's disease.Acta Neurol Scand: DOI: 10.1111/j.1600-0404.2010.01435.x. © 2010 John Wiley & Sons A/S. Objectives - To measure cerebrospinal fluid (CSF)

Until 4 decades ago, the rates of stroke in low- and middle-income countries were considerably lower than those in more economically robust countries. In the intervening years, however, the rates of stroke in places such as southern India and rural South Africa have approximately doubled, whereas stroke rates in more economically developed nations have decreased. What is far more striking is that

BACKGROUND: Cyclin A1 is a cell cycle regulator that has been implicated in the progression of prostate cancer. Its role in invasion and metastasis of this disease has not been characterized. METHODS: Immunohistochemistry and cDNA microarray analyses were used to assess protein and mRNA expression of cyclin A1 and proteins with roles in metastasis, including vascular endothelial growth factor (VEG

The faculty opposition of Stig Lundbergs licentiate thesis concerning the so-called Eskilstuna sarcophagi. The long dating-sequence of the stones and their unclear social origin aggravate their use in describing the state formation process. The author proposes a little dirrefent interpretaion than Lundberg.

The paper introduces a peer-to-peer system called P2PRIV (peer-to-peer direct and anonymous distribution overlay). Basic novel features of P2PRIV are: (i) a peer-to-peer parallel content exchange architecture, and (ii) separation of the anonymization process from the transport function. These features allow a considerable saving of service time while preserving high degree of anonymity. In the pap

Apolipoprotein M (apoM) is predominantly associated with HDL. In this study, it was investigated whether apoM's uncleaved signal peptide is necessary for the protein's ability to associate with lipoproteins. ApoM with a cleavable signal peptide, Q22A, was expressed, together with wild-type apoM, in HEK293 cells. On size-exclusion chromatography, the elution profile of wild-type apoM was similar to

The Lake Poopo basin, located on the Bolivian Altiplano, is extremely vulnerable to environmental degradation. The basin displays extreme spatial and temporal variations of water resources and rapidly decreasing water quality due to anthropogenic and natural pollution. The region’s population lives in extreme poverty, and the authorities’ efforts to manage the water resources efficiently have been

Pragma-dialectical argumentation theory has received criticism from epistemological argumentation theorists. While the former emphasizes argumentation as aimed at resolving differences of opinion through adequate procedures, the latter emphasizes that argumentation is aimed at reaching a justified conclusion of the argumentation. In this paper pragma-dialectics is analyzed and two objections consi