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The role of soundscape in nature-based rehabilitation: A patient perspective
Nature-based rehabilitation (NBR) has convincing support in research, yet the underlying mechanisms are not fully understood. The present study sought to increase understanding of the role of soundscapes in NBR, an aspect paid little attention thus far. Transcribed interviews with 59 patients suffering from stress-related mental disorders and undergoing a 12-week therapy programme in the rehabilit
Hip fracture; an interruption that has consequences four months after a hip fracture. A qualitative study
Sustainable insulation of historical wooden and stone buildings with lime-hemp
Bariatric surgery enhances splanchnic vascular responses in patients with type 2 diabetes
Bariatric surgery results in notable weight loss and alleviates hyperglycemia in patients with type 2 diabetes (T2D). We aimed to characterize the vascular effects of a mixedmeal and infusion of exogenous glucose-dependent insulinotropic polypeptide (GIP) in the splanchnic region in 10 obese patients with T2D before and after bariatric surgery and in 10 lean control subjects. The experiments were
Sustainable production indicators at factory level
Purpose - Sustainable production (SP) is a very broad area and the awareness and communication of the concept differ between varying levels in a company. The supposition is that the awareness and improvement of sustainability on shop floor level would improve, if a suitable set of indicators for measuring sustainability was available. The purpose of this paper is therefore to identify a list of pe
Amylin alters human brain pericyte viability and NG2 expression
Amylin, a pancreatic β-cell-derived peptide hormone, forms inclusions in brain microvessels of patients with dementia who have been diagnosed with type 2 diabetes and Alzheimer's disease. The cellular localization of these inclusions and the consequences thereof are not yet known. Using immunohistochemical staining of hippocampus and parahippocampal cortex from patients with Alzheimer's disease an
Effects of DPP-4 inhibitor linagliptin and GLP-1 receptor agonist liraglutide on physiological response to hypoglycaemia in Japanese subjects with type 2 diabetes : A randomized, open-label, 2-arm parallel comparative, exploratory trial
Dipeptidyl peptidase-4 (DPP-4) inhibitors reduce the risk of hypoglycaemia, possibly through augmentation of glucose-dependent insulinotropic polypeptide (GIP) action, but not that of glucagon-like peptide-1 (GLP-1) on glucagon secretion. To examine this model in Japanese individuals with type 2 diabetes (T2D), the effects of the DPP-4 inhibitor linagliptin on glucagon and other counter-regulatory
Simulating cross-shore material exchange at decadal scale. Model application
A model developed to describe long-term cross-shore (CS) exchange of sand and resulting profile evolution at regional scale was employed to simulate the evolution at three different sites. The model consists of modules for calculating dune erosion and overwash, bar-berm material exchange, and dune build-up by wind-blown sand transport, as described in detail in a companion paper (Larson et al., 20
Hepatic DPP4 DNA methylation associates with fatty liver
Hepatic DPP4 expression is elevated in subjects with ectopic fat accumulation in the liver. However, whether increased dipeptidyl peptidase 4 (DPP4) is involved in the pathogenesis or is rather a consequence ofmetabolic disease is not known. We therefore studied the transcriptional regulation of hepatic Dpp4 in young mice prone to diet-induced obesity. Already at 6 weeks of age, expression of hepa
Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes
Type 2 diabetes (T2D) is characterized by insulin resistance and impaired insulin secretion, but the mechanisms underlying insulin secretion failure are not completely understood. Here, we show that a set of co-expressed genes, which is enriched for genes with islet-selective open chromatin, is associated with T2D. These genes are perturbed in T2D and have a similar expression pattern to that of d
Paralympic athletes’ perceptions of their experiences of sports-related injuries, risk factors and preventive possibilities
Survey shows large differences between the Nordic countries in the use of less invasive surfactant administration
Aim: Less invasive surfactant administration (LISA), namely surfactant instillation through a thin catheter in the trachea during spontaneous breathing, is increasingly used for premature infants. We surveyed the use of this technique in the Nordic countries in autumn 2015. Methods: A link to a web-based survey of surfactant administration methods was emailed to the directors of all neonatal units
Neutron beam monitors for the European spallation source
Risk of malignant melanoma in relation to drug intake, alcohol, smoking and hormonal factors
Measuring the End of Life Premium in Cancer using Individual ex ante Willingness to Pay
For the assessment of value of new therapies in healthcare, Health Technology Assessment (HTA) agencies often review the cost per Quality-Adjusted Life-Years (QALY) gained. Some HTAs accept a higher cost per QALY gained when treatment is aimed at prolonging survival for patients with a short expected remaining lifetime, a so called End-Of-Life (EoL) premium. The objective of this study is to elici
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Controlling the urge to search : Studying the informational texture of practices by exploring the missing element
This paper examines situations in which people restrict themselves in order to control their online searching and how this is negotiated. It is framed in a sociomaterial perspective taking account of the entanglement of information technology with its users and the conditions of its use. It contributes to a conceptual discussion of the sociomaterial shaping of the informational texture of issues a