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Many microRNAs (miRNAs) are known to be cell-type specific and are implicated in development of diseases. We investigated the global expression pattern of miRNAs in human pancreatic islets compared to liver and skeletal muscle, using bead-based technology and quantitative RT-PCR. In addition to the known islet-specific miR-375, we also found enrichment of miR-127-3p, miR-184, miR-195 and miR-493∗

Although advances in neonatal care have resulted in increased survival rates among extremely preterm infants (born < 28 gestational weeks), they still face substantial morbidity risks during the neonatal period. The question of possible later outcomes is a key issue faced by health care professionals working with these infants. Objectives The objective of the present thesis was to explore develo

The aim of the thesis is to develop a model, based on well known physical and empirical formulas, to simulate the heat load on a rink of artificially frozen ice. A comparison of the results from this model and the results from other methods to determine heat load of the rink is made. The model calculates the heat load from convection, long wave radiation from the air temperature and from the sky t

Today, due to the fast development of Internet Protocol TV (IPTV), which is the combination of IP technology and two-way broadband networks, the telecom industry is undergoing fundamental changes. Network operators and service providers around the world are making significant investments in order to deliver digital video content to their subscribers. Video puts very high demands on the network and

OBJECTIVE: On December 8-9, 2014, the Pennington Biomedical Research Center convened a scientific symposium to review the state-of-the-science and future directions for the study of developmental programming of obesity and chronic disease. The objectives of the symposium were to discuss: (i) past and current scientific advances in animal models, population-based cohort studies, and human clinical

Drilling of a deep borehole does not normally allow for hydrologic testing during the drilling period. It is only done when drilling experiences a large loss (or high return) of drilling fluid due to penetration of a large-transmissivity zone. The paper proposes the possibility of conducting flowing fluid electrical conductivity (FFEC) logging during the drilling period, with negligible impact on

There is consistent evidence in the literature that an average employee's age is negatively related to firm-level innovativeness. This observation has been explained by older employees working with outdated technological knowledge and being characterized by reduced cognitive flexibility. We argue that firms can mitigate this effect through employee turnover. In particular, turnover of R&D work

This article argues that flexible knowledge (and thus continuous education) has the potential to out-date employment protection versus new forms of works as the touchstone oflabour law discourse in the Knowledge Society. Hitherto labour law discourse has usually focused on labour market segmentation in terms of a core group of permanently employed workers and more peripheral groups of workers in a

In our paper we address a gap in the literature, identified by Silverberg (2007), who claims that we miss an objective criteria for identifying leading sectors associated with technology-induced structural change and measuring their effects on functioning of the economy. In particular, we analyse the role of leading industries in labour reallocation across regions as a mechanism of smoothing regio

Virtual reality carries great promise to facilitate the building process. Some examples are the communication between architects and building companies, sellers and buyers or the community planners and the general public. It is often thought that in order to utilize the possibilities of VR, for example in the above-mentioned contexts, it is necessary to use full-fledged versions of VR including fo

The air around us is full of aerosol particles which originate from a myriad of sources and which have vastly different chemical and physical properties. These particles span size ranges from 1 nm to 100 μm, equivalent to a factor 100 000 in diameter difference and a factor 10^15 in volume difference. They affect our health by depositing in our airways, worsening cardiovascular deceases, and they

MOTIVATION: Depletion of loss-of-function (LoF) mutations may provide a rank of genic functional intolerance and consequently susceptibility to disease.RESULTS: Here we have studied LoF mutations in 60 706 unrelated individuals and show that the most intolerant quartile of ranked genes is enriched in rare and early onset diseases and explains 87% of de novo haploinsufficient OMIM mutations, 17% mo

Frontotemporal dementia (FTD) and Alzheimer's disease (AD) are two frequent causes of dementia that share both clinical and neuropathological features. Common to both disorders are the neurofibrillary tangles consisting of aggregations of hyperphosphorylated tau protein. Recently, a number of different pathogenic mutations in the tau gene have been identified in families with FTD and parkinsonism

The Vel blood group antigen is expressed on the red blood cells of most individuals. Recently, we described that homozygosity for inactivating mutations in SMIM1 defines the rare Vel-negative phenotype. Still, Vel-positive individuals show great variability in Vel antigen expression, creating a risk for Vel blood typing errors and transfusion reactions. We fine-mapped the regulatory region located