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Genetic profiling differentiates second primary tumors from metastases in adult metachronous soft tissue sarcoma.

Purpose. Patients with soft tissue sarcomas (STS) are at increased risk of second primary malignancies, including a second STS, but distinction between metastases and a second primary STS is difficult. Patients and Methods. Array-based comparative genomic hybridization (aCGH) was applied to 30 multiple STS of the extremities and the trunk wall from 13 patients. Different histotypes were present wi

VOLUMETRIC LOCALISATION OF DENSE BREAST TISSUE USING BREAST TOMOSYNTHESIS DATA.

This study attempted to use combined data from reconstructed digital breast tomosynthesis (DBT) volumes and density estimation of projection images to localise dense tissue inside the breast, using the assumption that the breast can be treated as consisting of only two types of tissue: fibroglandular (dense) and adipose (fatty). To be able to verify results, software breast phantoms generated usin

Physical limitations on antennas of arbitrary shape

In this paper, physical limitations on bandwidth, realized gain, Q-factor and directivity are derived for antennas of arbitrary shape. The product of bandwidth and realizable gain is shown to be bounded from above by the eigenvalues of the long-wavelength, high-contrast polarizability dyadics. These dyadics are proportional to the antenna volume and are easily determined for an arbitrary geometry.

A uniqueness theorem for the Helmholtz' equation: Penetrable media with an infinite interface

In this paper we will prove the uniqueness of a solution to Helmholtz' equation for two halfspaces of different media in $n$ dimensions. The theorem allows a finite number of bounded inhomogeneities in each half space. The surface separating the half spaces is assumed to be a cone of arbitrary cross section far away from the origin and is furthermore assumed to be smooth. We assume all space to be

ETS1 mediates MEK1/2-dependent overexpression of cancerous inhibitor of protein phosphatase 2A (CIP2A) in human cancer cells.

EGFR-MEK-ERK signaling pathway has an established role in promoting malignant growth and disease progression in human cancers. Therefore identification of transcriptional targets mediating the oncogenic effects of the EGFR-MEK-ERK pathway would be highly relevant. Cancerous inhibitor of protein phosphatase 2A (CIP2A) is a recently characterized human oncoprotein. CIP2A promotes malignant cell grow

Laminin-α2 Chain-Deficient Congenital Muscular Dystrophy: Pathophysiology and Development of Treatment.

Laminin-211 is a major constituent of the skeletal muscle basement membrane. It stabilizes skeletal muscle and influences signal transduction events from the myomatrix to the muscle cell. Mutations in the gene encoding the α2 chain of laminin-211 lead to congenital muscular dystrophy type 1A (MDC1A), a life-threatening disease characterized by severe hypotonia, progressive muscle weakness, and joi

Subjective Evaluation as a Tool for Learning from Software Project Success

This paper presents a method for using subjective factors to evaluate project success. The method is based on collection of subjective measures with respect to project characteristics and project success indicators. The paper introduces a new classification scheme for assessing software projects. Further, it is illustrated how the method may be used to predict software success using subjective mea

Sophie Creutz och hennes tid. Adelsliv i 1700-talets Finland.

The life and culture of the nobility in Finland in the 18-th and early 19-th centuries in Finland. Political culture and relations, everyday life an networks in Finland, Sweden and western parts of Russia. In the centre you find the families Creutz, Glansenstierna and Sprengtporten.

Development of speech motor control: Lip movement variability.

This study examined variability of lip movements across repetitions of the same utterance as a function of age in Swedish speakers. Subjects were 37 typically developed Swedish children and adults (19 females, 18 males, aged 5-31 yr). Lip movements were recorded during 15-20 repetitions of a short Swedish phrase using articulography, with a sampling rate of 200 Hz. After correction for head moveme

Bioinformatics services related to diagnosis of primary immunodeficiencies.

Most primary immunodeficiencies (PIDs) have overlapping signs and symptoms - presenting a challenge for diagnosis. The information available from the Internet for over 200 PIDs is scattered between numerous services and databases. Patient information has been collected in different patient registries. Several software tools have been developed in order to build the databases, expert systems and ot

Screening for cryptococcal antigenemia using the lateral flow assay in antiretroviral therapy-naïve HIV-positive adults at an Ethiopian hospital clinic.

Since treatment for latent cryptococcal infection (CI) before starting antiretroviral therapy (ART) reduces mortality in HIV-infected subjects, screening for cryptococcal antigen (CrAg) in blood is recommended for individuals with CD4 cell counts < 100 cells/µL in regions with high CI prevalence. We assessed CrAg screening using the lateral flow assay in HIV-infected adults eligible for ART in cen

A unique autophosphorylation site in the platelet-derived growth factor alpha receptor from a heterodimeric receptor complex

The platelet-derived growth factor (PDGF) alpha and beta receptors undergo dimerization as a consequence of ligand binding. Depending on the PDGF isoform (PDGF-AA, -AB or -BB), homodimers or heterodimers of receptors are formed. In this study, we have used transfected porcine aortic endothelial cells, coexpressing cDNAs for the alpha receptor and the beta receptor at comparable levels, to investig

The Origins of the Cashless Society: Cash Dispensers, Direct to Account Payments and the Development of On-Line Real-Time Networks, C. 1965-1985

This article explores the technological choices made at the dawn of the massification of retail finance. We describe and analyze the early development of electronic banking and the foundations of the cashless society through the experiences of organizations with similar governance in two different competitive environments — Swedish and British savings banks. We document how the adoption of direct-