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High-Throughput Separation of Long DNA in Deterministic Lateral Displacement Arrays

Length-based separation of DNA remains as relevant today as when gel electrophoresis was introduced almost 100 years ago. While new, long-read genomics technologies have revolutionised accessibility to powerful genomic data, the preparation of samples has not proceeded at the same pace, with sample preparation often constituting a considerable bottleneck, both in time and difficulty. Microfluidics

DNA movement in sub-20 nm nanoslits

The movement of XbaI digested O-DNA in 20 nanometer and O-DNA in 12 nanometer high slits was investigated. We found that DNA moved intermittently and following preferential pathways, indicating an important influence of surface roughness. From these intermittent movements two different mobilities were calculated, the total averaged mobilities and averaged mobilities between the intermittent sticki

Very preterm birth and fetal growth restriction in adolescence - Cardiovascular and renal aspects

This thesis applied magnetic resonance imaging (MRI) to investigate to what extent very preterm birth due to early onset fetal growth restriction (FGR) impacts the cardiovascular system and kidneys in adolescence. The thesis further investigated whether FGR exacerbates the organ-specific effects of very preterm birth.Study I validated a widely available non-contrast enhanced MRI method for quantif

The influence of adhesion molecules on binding and protein organization in cell contacts

Interactions between immune cells such as T cells and antigen-presenting cells (APCs) are integral for mounting an adaptive immune response. The interaction between the T cell receptor (TCR) and the antigen-presenting major histocompatibility complex (pMHC) on a contacting T cell and APC, is widely accepted to be the key interaction. If the interaction is favourable, then T cell activation occurs.

The Mantis Network II: examining the 3D high-resolution observable properties of the UHJs WASP-121b and WASP-189b through GCM modelling

The atmospheres of ultra hot Jupiters (UHJs) are prime targets for the detection of molecules and atoms at both low and high spectral resolution. We study the atmospheres of the UHJs WASP-121b and WASP-189b by performing 3D general circulation models (GCMs) of these planets using high temperature correlated-k opacity schemes with ultra-violet (UV) absorbing species included. The GCM results are th

Use of dielectrophoresis for directing T cells to microwells before nanostraw transfection : modelling and experiments

Nanostraw substrates have great potential for achieving minimally invasive cell transfection. Cells located on the nanostraw substrate are subjected to mild DC electric pulses applied across the nanostraw substrate, which open pores in the cell membrane on top of the nanostraws and drives charged cargo through these pores via electrophoresis. However, with this method, the current may leak through

Combining direct ground cooling with ground-source heat pumps and district heating : Borehole sizing and land area requirements

This article studies the potential combination of direct ground cooling (DGC) with district heating (DH) and ground source heat pumps (GSHP) to compare the required borehole depths and needed drilling areas. It also examines two different borehole sizing approaches to optimize investment costs and drilling areas. The results show that the required borehole depths in most cases are shorter for the

LEVELS OF IL-6 AND OTHER INFLAMMATORY PROTEINS IN EARLY RA PREDICT JOINT DAMAGE PROGRESSION OVER 5 YEARS

Background Joint damage in rheumatoid arthritis (RA) remains a significant problem. Identification of biomarkers associated with joint destruction can improve our understanding of underlying disease processes and future management.Objectives To evaluate inflammatory proteins as potential predictors of radiographic progression of joint damage.Methods Consecutive early RA patients (symptom duration

Intake of Dairy Products as a Risk Factor for Rheumatoid Arthritis; A Nested Case-Control Study

Background/Purpose: There has been increasing interest in diet as a factor that may contribute to the development of rheumatoid arthritis (RA). There is limited and somewhat contradictory information on the impact of dairy products in this context. The purpose of this study was to investigate the relation between intake of various dairy products and the risk of RA in a nested case-control study.Me

PREDICTORS OF EROSION AND JOINT SPACE NARROWING PROGRESSION IN PATIENTS WITH EARLY RHEUMATOID ARTHRITIS

Background: Joint damage in rheumatoid arthritis (RA) includes erosions and joint space narrowing (JSN). Predictors of these processes, and the underlying mechanisms, require further study1.Objectives: To investigate the relation between patient characteristics at RA diagnosis and progression of erosions and JSN, over 5 years. Methods: Consecutive early RA patients (symptom duration Results: 233 e

High Disease Activity over Time and Persistent Inflammation Are Associated with Increased Risk of Cardiovascular Disease in Patients with Early Rheumatoid Arthritis

Background/Purpose:Rheumatoid arthritis (RA) is associated with an increased rate of cardiovascular (CV) disease. Systemic inflammation has been implicated as a key factor behind CV comorbidity in RA. The objective of this study was to investigate the impact of disease activity and inflammation over the first two years on the risk of subsequent CV events in patients with early RA.Methods:An incept

Investigating Ancient Agricultural Field Systems In Sweden From Airborne Lidar Data By Using Convolutional Neural Network

Today, the advances in airborne LIDAR technology provide high-resolution datasets that allow specialists to detect archaeological features hidden under wooded areas more efficiently. Still, the complexity and large scale of these datasets require automated analysis. In this respect, artificial intelligence (AI)-based analysis has recently created an alternative approach for interpreting remote sen

Capturing the Senses : Digital Methods for Sensory Archaeologies

This open-access book surveys how digital technology can contribute effectively to improving our understanding of the past, through a sensory engagement based on the evidence of material culture. In particular, it encourages specialists to consider senses and human agency as important factors in studying ancient space, while recognising the role played by digital tools in enhancing a human-centred

Criminal Law

The book contains a summary presentation of the Swedish legal system, written by leading Swedish experts in their respective legal fields. It is intended to be used by foreign law students participating in introductory courses in Swedish law, foreign legal professionals looking for fundamental information about the Swedish approach to a particular legal problem and Swedish lawyers when communicati

Maternal age and the risk of low birthweight and pre-term delivery: a pan-Nordic comparison

Advanced maternal age at birth is considered a risk factor for adverse birth outcomes. A recent study applying a sibling design has shown, however, that the association might be confounded by unobserved maternal characteristics. Methods: Using total population register data on all live singleton births during the period 1999-2012 in Denmark (N = 580-133; 90% population coverage), Norway (N = 540-8

The Relation Between Peritraumatic Dissociation and Coping Strategies: A Network Analysis

Objective: Peritraumatic dissociation (PD) and coping strategies (CS) around the time of trauma are significantpredictors of acute and long-term posttraumatic symptomatology (PTS), but it is unclear howthey relate to each other. The aim of this study was to examine their association using a nationwide, representativesample following the September 11 attacks in the United States (N = 3,134). Method

The indirect review of administrative action in Sweden : Control and judicial protection

The chapter examines the role of indirect review of administrative action in Swedish law. A general description of the overall structure of the Swedish system for judicial review of administrative action is followed by a discussion about the administrative measures that cannot be reviewed in a direct review. The chapter then focuses specifically on the phenomenon of indirect judicial review in relThe chapter examines the role of indirect review of administrative action in Swedish law. A general description of the overall structure of the Swedish system for judicial review of administrative action is followed by a discussion about the administrative measures that cannot be reviewed in a direct review. The chapter then focuses specifically on the phenomenon of indirect judicial review in rel

An experimental investigation of the accuracy of thermal response tests used to measure ground thermal properties

This paper reports on the results of thermal response tests conducted with laboratory-grade instrumentation and equipmentfor a borehole system consisting of nine groundwater-filled boreholes, each about 80 m (262 ft) deep. The ground thermalproperties, including the undisturbed ground temperature, the thermal conductivity and the borehole thermal resistance, aredetermined for each of the nine bore