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Risk of major depression in partners of people with Alzheimer's disease : A national cohort study

Background Alzheimer's disease (AD) may cause significant psychosocial distress not only in the patient but also their partner. However, long-term risks of major depression in partners of AD patients are largely unknown. Methods A national cohort study was conducted of all 145 289 partners of people diagnosed with all-cause dementia, including 57 113 partners of people diagnosed with AD, in Sweden

Comparing dose response of cancer incidence in Sweden after the Chernobyl Nuclear Power Plant accident with Life Span Study of atomic bomb survivors

Follow-up of the atomic bomb survivors in Japan in the Life Span Study (LSS) has been fundamental for the understanding of the dose–response curve. We compare our risk estimates from a newly published epidemiological study on cancer in Sweden after the Chernobyl Nuclear Power Plant accident with the LSS data. Hazard ratios (HRs) with 95% confidence intervals (95% CIs) were calculated using conditi

Multiplicity of Asymptomatic Plasmodium falciparum Infections and Risk of Clinical Malaria : A Systematic Review and Pooled Analysis of Individual Participant Data

BACKGROUND: The malaria parasite Plasmodium falciparum holds an extensive genetic polymorphism. In this pooled analysis, we investigate how the multiplicity in asymptomatic P. falciparum infections-that is, the number of coinfecting clones-affects the subsequent risk of clinical malaria in populations living under different levels of transmission.METHODS: A systematic search of the literature was

Validation and proposal of a clinical intervention cutoff in fetal scalp blood for the point-of care-lactate meter StatStrip®2

IntroductionThis multicenter, prospective observational study aimed to evaluate the performance of the StatStrip® Lactate 2 (Nova Biomedical, Waltham, US) point-of-care device for fetal blood lactate measurement and to determine the corresponding lactate value equivalent to the established intervention cutoff used with the outgoing StatStrip® Lactate device.Material and MethodsThe study was conducIntroduction: This multicenter, prospective observational study aimed to evaluate the performance of the StatStrip® Lactate 2 (Nova Biomedical, Waltham, US) point-of-care device for fetal blood lactate measurement and to determine the corresponding lactate value equivalent to the established intervention cutoff used with the outgoing StatStrip® Lactate device. Material and Methods: The study was c

Electrostatics and viscosity are strongly linked in concentrated antibody solutions

Monoclonal antibodies are among the most promising therapeutic agents in modern medicine, yet their formulation into high-concentration solutions for subcutaneous self-administration poses a major challenge. A key obstacle is the marked increase in viscosity often observed under these conditions. To gain deeper insights into this phenomenon, coarse-grained models derived from soft matter physics h

Activity-focused powered mobility practice: Applying the process-based tool Assessment of Learning Process (ALP : (Educational session, 90 min)

Learning objectives: Describe the 3 stages of exploration and the 8 phases in the learning processCompare and contrast process-based and task-based assessmentEvaluate applicability of the presented knowledge in your professional practice Session description: Activity-based focus for practice in a power mobility device suggests integration of learning device-use in other activities aligning with th

Utformning av hastighetssäkrade åtgärder på landsbygd : Resultat ifrån ett experiment i körsimulator

Denna rapport handlar om utformningen av hastighetssäkrade åtgärder på landsbygd, mer specifikt så har ett experiment i en körsimulator utförts för att studera hur hastigheten genom åtgärden påverkas när man ökar eller minskar åtgärdens längd och bredd (sidoförskjutning). Experimentet har utgått ifrån två existerande platser där flera olika förändringar av geometrin gjorts i den digitala miljön. E

The Russian daily press, 1978-2003 : Political argumentation and the problematic public sphere

The language of newspapers in the public sphere has a crucial impact on how the public perceives and participates in society. It can serve to encourage or counteract active and informed citizens; in fact, it is a crucial element in democratisation processes. The purposes of the present study are to elucidate what means of persuasion are used to support theses on politics in newspaper discourse dur

The universal approach for facilitating participation, tool-use learning and application of the ALP-facilitating strategies : (Instructional course, 45 min)

Dr Lisbeth NilssonLearning objectives:1. Describe at least three essential aspects of the facilitating approach.2. Explain why these aspects can facilitate optimal outcomes of intervention.3. Evaluate usefulness of the universal facilitating approach in your own practice.Session description:The process of learning joystick-use and training strategies for each phase in the process were identified i

Exploring why powered mobility experiences can accelerate overall development in infants aged 3-12 months : (oral presentation 30 min)

Dr Lisbeth NilssonLearning objectives:1. Discover how and why technology can enable non-mobile infants and children in developing tool-use and participation with the world.2. Explain how and why experiences of self-produced movement in a powered device can impact on very young infants’ overall development3. Motivate provision of opportunities to explore and experience powered mobility to very youn

Statistical Data Analysis of Inspection Outcomes of Post-Tensioned Concrete Bridges in Italy

Corrosion of cables can result in brittle and unexpected failures and represents a critical concern for prestressed concrete bridges with post-tensioned (PT) tendons. In these structures, corrosion is typically facilitated by inadequate grout injection and/or the use of poor-quality mortar during construction. Such deficiencies create favorable conditions for corrosion initiation and propagation.

Ventilation in Adaptive Reuse : Reducing uncertainty in concept-stage decisions

För att minska och försöka eliminera utsläppen av koldioxid från byggsektorn krävs alternativ till dagens metod att skapa önskad funktion genom att riva befintliga byggnader följt av nyproduktion. Nyproduktion av byggnader medför stora klimatbelastande utsläpp kopplade till framställning av nya produkter och material, men även kopplat till rivnings- och nybyggnadsprocessen. Samtidigt är en del av Decarbonisation of the built environment requires alternatives to the prevailing practice of demolition followed by new construction. The new production of buildings adds upfront embodied emissions, while much of the non-residential stock remains underutilised, and housing demand remains high. Adaptive reuse, the practice of converting existing buildings for new functions, preserves the building's

Cumulative triglyceride-glucose index and hypertension risk : a longitudinal cohort study

BACKGROUND: Prior research has established a positive association between the single-measured triglyceride-glucose (TyG) index and hypertension. Nevertheless, longitudinal studies addressing the enduring impact of TyG index on incident hypertension are lacking. This study sought to explore the association between cumulative TyG index (cum-TyG) and incident hypertension, especially obesity-related

Two years of the initiative Teaching for Sustainability at Lund University – understanding challenges and exploring opportunities

In a world where the challenges of climate change, social inequality, economic instability, and geopolitical tensions are ever-present, educators have a unique opportunity—and responsibility—to prepare their students to navigate these complexities. However, educators are also juggling teaching and research, competing deadlines, shifting expectations, institutional paradigms, and limited time and s

Taurine Intake, Plasma Taurine Concentration, and Dementia Risk : Findings From the Malmö Diet and Cancer Study

Preclinical studies suggest that taurine may exert neuroprotective effects. However, its relevance to dementia risk in human populations remains unclear. We investigated the associations between mid-life dietary taurine intake, circulating taurine concentrations, and the risk of late-life all-cause dementia, Alzheimer's disease (AD), and vascular dementia (VaD) in a large prospective cohort. This

Preclinical Validation of [177Lu]Lu-AKIR001, a CD44v6-Targeted Radiotherapeutic Entering First-in-Human Trials

Targeted radionuclide therapy is an emerging potent therapeutic strategy in oncology. The cell surface antigen CD44v6 is a potential pan-cancer target for radionuclide therapy. This study aimed to evaluate the therapeutic efficacy, biodistribution, dosimetry, and safety profile of AKIR001, an antibody targeting CD44v6 labeled with 177Lu. Methods: The biodistribution and preclinical dosimetry of [1