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Nodularin (Nod), produced by the brackish/marine cyanobacterium Nodularia spumigena, is a potent hepatotoxin, tumor promoter and is possibly carcinogenic to mammals. It is structurally and toxicologically related to the microcystins, produced by Microcystis aeruginosa in fresh water. A better understanding of the kinetics of Nod production might provide an insight into the physiological and ecolog

Thin trabeculae were dissected from the right ventricle of guinea-pig heart and stimulated to contract isometrically at 0.5 Hz (26 degrees C). Rapid and transient changes of force were obtained by inducing three extra systoles (ES1-3) at 450-ms intervals. The two regular contractions (P1-2) following (ES1-3) were potentiated. Fura-2 salt was microinjected into the preparation to monitor intracellu

Photophysical studies of pseudo-p-distyryl[2.2]paracyclophane, a model molecule of a stilbene dimer arranged in a brick-wall geometry, in tetrahydrofurane solution indicate the existence of at least two conformers in the ground state. The conformer A with the smallest optical gap of 3 eV has a short radiative lifetime of 3.3 ns, while the conformer B with an optical gap about 0.3 eV larger is much

Objectives. To study the combined effects of a low birth weight and a pronounced weight increase up to early adulthood on the presence of cardiovascular risk factors constituting the metabolic syndrome in late middle age. Design and setting. A structured sample of 396 men, 58 years old from the general population. Birth weight and weight at 18 years were obtained from medical records and registers

Popular Abstract in Swedish Att packa ryggsäcken och resa till tropikerna, till vad man ofta kallar ‘tredje världen’ för en längre tids vistelse anses ofta vara av avsevärd betydelse för en individs identitet och framtida liv. För många resenärer upplevs resan som ett sätt att ta kontroll över den egna tiden och rörelsen, en kontroll som betraktas som en bristvara i de miljöer resenärerna kommer fThis work addresses the phenomenon of long-term, so-called ‘independent’ travelling, or backpacking, often to destinations described as the ‘third world’. It regards backpacker journeys as arenas for identity work, for expressing individuality and a ‘strong character’. Rather than merely being a parenthetic detour in time and space a backpacker’s trip to the tropics can be understood as a creative

The possibility of using pervaporation for the recovery of natural aroma compounds in the food industry has been widely recognised. The aim of this study was to build a bridge between experimental studies of multi-component systems and potential applications of pervaporation in the food industry. Therefore, a novel process simulation of pervaporation has been developed for multi-component mixtures

Lying athwart both the temperate and subtropical zones, the Ning-Zhen Mountains are particularly prone to extreme floods in the summer months when cold fronts collide with the subtropics-derived warm airmasses. The Holocene flood deposits in the region may provide a long-term perspective on hydrographical change and its palaeoclimatic implications. Radiocarbon dates on carbonised wood preserved in

Recovery of electroencephalographic activity and somatosensory evoked responses was studied in paralyzed and lightly anesthetized (70% N2O) rats in which profound hypoglycemia had been induced by insulin administration. The duration of severe hypoglycemia was defined as the duration of a flat electroencephalogram (EEG) recording (5, 30, and 60 min, respectively) before restitution with glucose. Th

Aim: To explore whether the phrasing of the questions and the response alternatives would influence the answers to questions about legalisation of euthanasia. Methods: Results were compared from two different surveys in populations with similar characteristics. The alternatives "positive'', "negative'', and "don't know'' (first questionnaire) were replaced with an explanatory text, "no legal sanct

Objective: To assess the therapeutic effects of oral zileuton tablets combined with low-dose beclomethasone compared to doubling the dose of beclomethasone, in improving lung function and reducing asthma symptoms. Methods: Randomized, active-controt, double-blind, parallel, multi-center study of zileuton (400 or 600mg QID)+200 mu g beclomethasone dipropionate (BDP) BID versus ptacebo+BDP 400pg BID

Abstract is not available

The objective of the present investigation was to develop a technique to synthesize submicronic particles of Nb-doped strontium titanate with a homogeneous composition. This was achieved by a modified glycine-nitrate process, using Ti-lactate, Nb-oxalate, and Sr(NO3)(2) as starting materials. A combination of both citric acid and glycine was needed in order to integrate the useful features of both

Antibody evolution in vivo proceeds mainly by stepwise improvements, accomplished by single base pair substitutions. Lately, receptor revision, i.e. exchange of large parts of the V gene for another sequence, has been suggested to provide a complementary route for affinity maturation. By employing a receptor revision like evolution process in vitro using combinatorial libraries and phage display s

The role of photosynthetic pigments in the development of separation methods in biochemistry during the period 1900-1980 is described beginning with M. Tswett who introduced separation of chlorophylls and carotenoids on columns and coined the term chromatography in 1906. In Uppsala, T. Svedberg developed the ultracentrifuge in the 1920s. A. Tiselius improved electrophoresis in the 1930s and develo