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The use of sociocultural valuation in sustainable environmental management

The integration of sociocultural valuations (SCV) within an ecosystem services (ES) framework is increasingly being required in environmental management contexts. Yet, this raises important questions: how do we approach SCV when people's perceptions are based on unbalanced information and advocate for detrimental actions? How then should SCV results be used? Should they be used to steer decisions?

Comprehensive Mass Spectrometric Survey of Streptococcus pyogenes Subcellular Proteomes

Streptococcus pyogenes is a major global health burden causing a wide variety of diseases. Because a vaccine against this bacterium is still lacking, vaccine candidates or antimicrobial therapies are urgently needed. Here we use an invasive and clinically relevant streptococcal M1 serotype to characterize the bacterial proteome in-depth. An elaborate fractionation technique is employed to separate

Declining oxygen in the global ocean and coastal waters

Oxygen is fundamental to life. Not only is it essential for the survival of individual animals, but it regulates global cycles of major nutrients and carbon. The oxygen content of the open ocean and coastal waters has been declining for at least the past half-century, largely because of human activities that have increased global temperatures and nutrients discharged to coastal waters. These chang

Geoengineering : neither economical, nor ethical—a risk–reward nexus analysis of carbon dioxide removal

This article addresses a central debate in combatting climate change: whether we should focus on reducing CO2 emissions or on removing the emitted CO2 from the atmosphere. We favor the former by arguing against the economic viability of the carbon dioxide removal (CDR) branch of geoengineering. This is of course not a question of either or, but we argue that the perception of CDR as a viable optio

Mind the gap : The role of mindfulness in adapting to increasing risk and climate change

It is becoming clear that increasingly complex global challenges cannot simply be solved by new technology or governments alone. We also need to develop new social practices and encourage a broader cultural shift towards sustainability. Against this background, this paper explores the role of mindfulness in adapting to increasing risk and climate change. Based on a literature review, it assesses c

Tracking the picosecond deactivation dynamics of a photoexcited iron carbene complex by time-resolved X-ray scattering

Recent years have seen the development of new iron-centered N-heterocyclic carbene (NHC) complexes for solar energy applications. Compared to typical ligand systems, the NHC ligands provide Fe complexes with longer-lived metal-to-ligand charge transfer (MLCT) states. This increased lifetime is ascribed to strong ligand field splitting provided by the NHC ligands that raises the energy levels of th

Fenton reaction facilitates organic nitrogen acquisition by an ectomycorrhizal fungus

Boreal trees rely on their ectomycorrhizal fungal symbionts to acquire growth-limiting nutrients, such as nitrogen (N), which mainly occurs as proteins complexed in soil organic matter (SOM). The mechanisms for liberating this N are unclear as ectomycorrhizal fungi have lost many genes encoding lignocellulose-degrading enzymes present in their saprotrophic ancestors. We hypothesized that hydroxyl

Exploration of H2 binding to the [NiFe]-hydrogenase active site with multiconfigurational density functional theory

The combination of density functional theory (DFT) with a multiconfigurational wave function is an efficient way to include dynamical correlation in calculations with multiconfiguration self-consistent field wave functions. These methods can potentially be employed to elucidate reaction mechanisms in bio-inorganic chemistry, where many other methods become either too computationally expensive or t

Signatures of selection in embryonic transcriptomes of lizards adapting in parallel to cool climate

Populations adapting independently to the same environment provide important insights into the repeatability of evolution at different levels of biological organization. In the 20th century, common wall lizards (Podarcis muralis) from southern and western Europe were introduced to England, north of their native range. Nonnative populations of both lineages have adapted to the shorter season and lo

Mechanosensing Using GaInP Nanowires

Mechanical forces exists in many cellular processes, including cell proliferation, migration, rearrangement and differentiation. The transformation of cancer cells from normal cells, cancer metastasis and cell rearrangement during morphogenesis all involve changes in cellular mechanical forces. Although there are some studies about normal cell and cancer cell force measurements, a direct compariso

Omförhandlingar : Kropp, replik, etik

Renegotiations: Body, Line, Ethics departs from questions concerning authorship and agency for actors in institutionalised settings and moves towards a discussion on ethics, responsibility and possibilities in the body – text relationship. The question of how bodies can be renegotiated in and by the theatrical line is central to the work. Against a backdrop of previous and other stage productions

Representing the Region on the Floor : Socioeconomic Characteristics of Electoral Districts and Legislative Speechmaking

Does it matter which electoral districts Members of Parliament (MPs) represent when participating in parliamentary debates? We suggest that the party leadership, in particular in governing parties, will try to keep MPs off the floor if they come from regions with economic problems, because such MPs are more likely to deviate from the party line. This should be especially likely when MPs are direct

The role of charge and proton transfer in fragmentation of hydrogen-bonded nanosystems : The breakup of ammonia clusters upon single photon multi-ionization

The charge and proton dynamics in hydrogen-bonded networks are investigated using ammonia as a model system. The fragmentation dynamics of medium-sized clusters (1-2 nm) upon single photon multi-ionization is studied, by analyzing the momenta of small ionic fragments. The observed fragmentation pattern of the doubly- and triply-charged clusters reveals a spatial anisotropy of emission between frag

The cartilage-specific lectin C-type lectin domain family 3 member A (CLEC3A) enhances tissue plasminogen activator-mediated plasminogen activation

C-type lectin domain family 3 member A (CLEC3A) is a poorly characterized protein belonging to the superfamily of C-type lectins. Its closest homologue tetranectin binds to the kringle 4 domain of plasminogen and enhances its association with tissue plasminogen activator (tPA) thereby enhancing plasmin production, but whether CLEC3A contributes to plasminogen activation is unknown. Here, we recomb

The future of sustainability science: a solutions-oriented research agenda

Over the last decade, sustainability science has been at the leading edge ofwidespread efforts from the social and natural sciences to produce use-inspired research.Yet, how knowledge generated by sustainability science and allied fields will contribute totransitions toward sustainability remains a critical theoretical and empirical question forbasic and applied research. This article explores the

Clinical application and psychometric properties of a norwegian questionnaire for the self-assessment of communication in quiet and adverse conditions using two revised APHAB subscales

Background: Difficulty in following and understanding conversation in different daily life situations is a common complaint among persons with hearing loss. To the best of our knowledge, there is currently no published validated Norwegian questionnaire available that allows for a self-assessment of unaided communication ability in a population with hearing loss. Purpose: The aims of the present st

Rationally Designed Chemically Modified Glycodendrimer Inhibits Streptococcus suis Adhesin SadP at Picomolar Concentrations

Host cell surface carbohydrate receptors of bacterial adhesins are attractive targets in anti-adhesion therapy. The affinity of carbohydrate ligands with adhesins is usually found in the low μm range, which poses a problem for the design of effective inhibitors useful in therapy. In an attempt to increase the inhibitory power of carbohydrate ligands, we have combined the approach of chemical modif

Comparative genomics reveals that loss of lunatic fringe (LFNG) promotes melanoma metastasis

Metastasis is the leading cause of death in patients with advanced melanoma, yet the somatic alterations that aid tumour cell dissemination and colonisation are poorly understood. Here, we deploy comparative genomics to identify and validate clinically relevant drivers of melanoma metastasis. To do this, we identified a set of 976 genes whose expression level was associated with a poor outcome in