Development of B-lymphoid cells in the bone marrow is a process under strict control of a hierarchy of transcription factors. To understand the development of a B-lymphoid-restricted functional network of transcription factors, we have investigated the cell autonomous role of the transcription factor EBF1 in early B cell development. This revealed that even though transplanted EBF1-deficient fetal

We consider a family of associative algebras, defined as the quotient of a free algebra with the ideal generated by a set of multi-parameter deformed commutation relations between four generators consisting of five quantum plane relations between pairs of generators and one sub-quadratic relation inter-linking all four generators. For generic parameter vectors, the center and the commutants of the

A hidden Markov model (HMM) is employed to improve noise robustness when tracking the dominant frequency of atrial fibrillation (AF) in the electrocardiogram (ECG). Following QRST cancellation, a sequence of observed frequency states is obtained from the residual ECG, using the short-time Fourier transform. Based on the observed state sequence, the Viterbi algorithm retrieves the optimal state seq

Doppler observations from Keck Observatory have revealed a triple-planet system orbiting the nearby K4V star, HIP 57274. The inner planet, HIP 57274b, is a super-Earth with M sin i = 11.6 M-circle plus (0.036 M-Jup), an orbital period of 8.135 +/- 0.004 days, and slightly eccentric orbit e = 0.19 +/- 0.1. We calculate a transit probability of 6.5% for the inner planet. The second planet has M sin

To enhance their applicability in a broader range of pervaporation feed streams, poly[1-(trimethylsilyl)-1-propyne] (PTMSP) membranes have been successfully crosslinked, using a 3,3'-diazido-diphenylsulfone crosslinker. Both photochemical and thermal processes were used to activate the bis(azide) and thus initiate the crosslink reaction. The presented photochemical crosslink process, has an insuff

Archaea are ubiquitous in forest soils, but little is known about the factors regulating their abundance and distribution. Low molecular weight organic compounds represent an important energy source for archaea in marine environments, and it is reasonable to suspect that archaeal abundance is dependent on such compounds in soils as well, represented by, for example, plant and fungal exudates. To t

Migration, proliferation and stem cell-like activity are all key cellular characteristics which aid the formation and progression of breast cancer, in addition to involvement in treatment resistance. Many current therapies aim to target tumour proliferation, and although successful, mortality rates in breast cancer remain significant. Our main objectives were to investigate the relationship betwee

Context: MicroRNAs (miRNA) are noncoding RNAs that post- transcriptionally regulate gene expression. Their altered expression and function have been observed in most urologic cancers. MiRNAs represent potential disease biomarkers and novel therapeutic targets. Objective: To review and evaluate the evidence implicating miRNAs in the pathogenesis of prostate cancer (PCa), bladder cancer (BCa), and r

This study depicts how the Armenian massacres in the Ottoman Empire during World War I were perceived by a neutral small state, namely, Sweden. The Swedish knowledge should be of special interest since, as a neutral state during the entire conflict, Sweden had no immediate involvement or interest in the ongoing conflict; thus, any reporting about the events would have been untainted compared to th

Background/Objectives: Given the importance of nutrition therapy in diabetes management, we hypothesized that food intake differs between individuals with and without diabetes. We investigated this hypothesis in two large prospective studies including different countries and ethnic groups. Subjects/Methods: Study populations were the European Prospective Investigation into Cancer and Nutrition Stu

Despite recent attempts to relax the phase-noise demands on voltage-controlled oscillators (VCOs) for cellular communications [1], mainstream radios require harmonic VCOs capable of a very low phase noise with moderate power consumption, associated to a large tuning range (TR) and a high insensitivity to interfering signals. Ideally, the TR should be in excess of one octave, since this allows the

In this paper, a novel multiple representation data structure for dynamic visualisation of 3D city models, called CityTree, is proposed. To create a CityTree, the ground plans of the buildings are generated and simplified. Then, the buildings are divided into clusters by the road network and one CityTree is created for each cluster. The leaf nodes of the CityTree represent the original 3D objects

In this thesis, genetic alterations in bone and soft tissue tumors have been investigated with the purpose of identifying regions of importance for tumor development, diagnosis and prognosis. This has primarily been performed by array comparative genomic hybridization analysis and gene expression profiling of cytogenetically analyzed tumors. In Article I, the content of ring chromosomes in a subse

Popular Abstract in Swedish Blod består av flera olika typer av mogna celler som har specialiserat sig på olika uppgifter, till exempel transporterar röda blodkroppar, erytrocyter, syre, medan lymfoida celler, sk B och T-celler är en del av vårt immunförsvar. Alla dessa mogna celler kan bildas från en cell, nämligen den hematopoietiska stamcellen. Stamcellens dotterceller utvecklas sedan till mer All hematopoietic cells originate from hematopoietic stem cells (HSCs) residing in the bone marrow (BM). The classical model of hematopoietic lineage commitment, that has been the prevailing model for hematopoiesis, proposes that the first lineage commitment step of HSCs and progenitors results in a strict separation of myelopoiesis and lymphopoiesis. However, an alternative model has already been

A method based on the coupled decay-chain equations for extracting the isotopic and the isomeric composition of a postaccelerated radioactive ion beam is presented and demonstrated on a data set from a Coulomb excitation experiment. This is the first attempt of analyzing the content of a postaccelerated radioactive ion beam using this technique. The beam composition is required for an absolute nor

Reclamation on bare tailing ponds has the potential to represent soil genesis in Technosols favoring the understanding of the changes of microbial communities and function. In this study we used phytostabilization aided with calcium carbonate and pig slurry/manure to reclaim an acidic bare tailing pond with the aim of investigating the effect of amending and different species on microbial communit