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The Saccharomyces cerevisiae gene deletion collection is widely used for functional gene annotation and genetic interaction analyses. However, the standard G418-resistance cassette used to produce knockout mutants delivers strong regulatory elements into the target genetic loci. To date, its side effects on the expression of neighboring genes have never been systematically assessed. Here, using ri
Impairment of normal hematopoiesis and leukemia progression are 2 well-linked processes during leukemia development and are controlled by the bone marrow (BM) niche. Extracellular matrix proteins, including laminin, are important BM niche components. However, their role in hematopoiesis regeneration and leukemia is unknown. Laminin α4 (Lama4), a major receptor-binding chain of several laminins, is
The research on forgeries, fakes, copies, replicas, facsimiles, substitutions, appropriations and imitations in pre-modern times is now a growing field of research in art history, and as shown the difference between these concepts is anything but clear (Heisterberg, Müller-Bechtel & Putzger eds. 2018; Cupperi ed. 2014; Wood 2008). The aim of this paper is to look at the artistic production of
Abstract: Despite an avalanche of recent court decisions on the European system for supplementary protection certificates (SPCs), the issue of third party SPC applications - also known as “SPC squatting” – has never been sufficiently clarified. Considering the ambiguous stipulations in the SPC Regulations, as well as the practical and theoretical significance of this issue, the lack of judicial gu
Resolving the structural dynamics of the initial steps of chemical reactions is challenging. We report the femtosecond time-resolved wide-angle X-ray scattering of the photodissociation of diiodomethane in cyclohexane. The data reveal with structural detail how the molecule dissociates into radicals, how the radicals collide with the solvent, and how they form the photoisomer. We extract how trans
The Phoenicians were the dominant traders in the Mediterranean Sea two thousand to three thousand years ago and expanded from their homeland in the Levant to establish colonies and trading posts throughout the Mediterranean, but then they disappeared from history. We wished to identify their male genetic traces in modern populations. Therefore, we chose Phoenician-influenced sites on the basis of
The last 20 years have seen dramatic improvements in the performance of algorithms for Boolean satisfiability-so-called SAT solvers-and today conflict-driven clause learning (CDCL) solvers are routinely used in a wide range of application areas. One serious short-coming of CDCL, however, is that the underlying method of reasoning is quite weak. A tantalizing solution is to instead use stronger pse
Exposure to environmental pollutants is a major public health concern. This study investigated the inflammatory and tumorigenic effects of environmental pollutants (benzene, benzo[a]pyrene, cadmium, and diisononyl phthalate) on transformed A549 and H292 lung alveolar epithelial cells and non-transformed BEAS-2B lung bronchial epithelial cells. The cytotoxic effects of the pollutants were analyzed
Nitrogen (N) availability is a powerful controller of soil carbon (C) cycling in temperate forests, affecting plant productivity and microbial activities. Enhanced rhizosphere input from increased plant productivity can stimulate the decomposition of native soil organic matter (SOM), termed the “priming effect”, with an effect size that is affected by N availability. Using soils from N-fertilizati
Purpose: The purpose of this paper is to investigate the role of smartphones among young people in everyday life, focusing on the activity of online search. This paper addresses the following research questions: What framings of the smartphone can be identified in the way that young people use, and describe, smartphones? What is the role of online search within these framings? By elucidating frami
This article seeks to explore and analyse the capacity of Swedish municipalities to implement measures for in- creased cycling. Through the concept of local capacity and against the backdrop of interviews with local cycle planners, the aim of the article is to gain deeper insights into cycle planners’ experiences and perspectives on what the possibilities, obstacles and challenges are as regards aThis article seeks to explore and analyse the capacity of Swedish municipalities to implement measures for increased cycling. Through the concept of local capacity and against the backdrop of interviews with local cycle planners, the aim of the article is to gain deeper insights into cycle planners’ experiences and perspectives on what the possibilities, obstacles and challenges are as regards ach
With the full-scale colonization of Hokkaido, home to the indigenous Ainu people, by the Japanese Meiji government (1868-1912), unprecedented ethnographic opportunities emerged for Western scientists and adventure-seekers. Literally dozens of such individuals “discovered” information about the Ainu and their homeland during this period, introducing European and American audiences to the subject th
Background: A negative oral contrast agent (OCA) has been long sought for, to better delineate the bowel and visualise surrounding structures. Lumentin® 44 (L44) is a new OCA formulated to fill the entire small bowel. The aim of this study was to compare L44 with positive and neutral conventional OCA in abdominal computed tomography (CT). Methods: Forty-five oncologic patients were randomised to r
This paper investigates the role of human agency in 40 phases of regional economic development in 12 Nordic regions over 30 years. It contributes with a theoretical framework to study agency over time and a fuzzy-set qualitative comparative analysis based on a unique dataset combining over 200 interviews, with printed and online sources, and quantitative data. The paper identifies which combinatio
Advanced personalized immunotherapies still have to overcome several biomedical and technical limitations before they become a routine cancer treatment in spite of recent achievements. In adoptive cell therapy (ACT), the capacity to obtain adequate numbers of therapeutic T cells in the patients following ex vivo treatment should be improved. Moreover, the time and costs to produce these T cells sh
