Impairment in beta-cell exocytosis is associated with reduced insulin secretion and diabetes. Here we aimed to investigate the dynamics of Ca2+-dependent insulin exocytosis with respect to pool depletion and Ca2+-current inactivation. We studied exocytosis, measured as increase in membrane capacitance (ΔCm), as a function of calcium entry (Q) in insulin secreting INS-1 832/13 cells using patch cla

The focus of this paper is on how organizational change within medical research evolves and is influenced by different types of institutions at different geographical levels, as well as what characteristics of the key individuals are important in enacting institutional opportunities and overcoming hindrances. The paper reveals the complexity of institutions influencing change processes. First, the

The expression of the inflammatory G-protein coupled receptor CysLT1R has been shown to be upregulated in colon cancer patients and associated with poor prognosis. The present study investigated the correlation between CysLT1R and colon cancer development in vivo using CysLT1R antagonists (ZM198,615 or Montelukast) and the nude mouse xenograft model. Two drug administration regimens were establish

A new simulation method for nonuniform polymer solutions between planar surfaces at full chemical equilibrium is described. The technique uses a grid of points in a two-dimensional thermodynamic space, labeled by surface area and surface separations. Free energy differences between these points are determined via Bennett's optimized rates method in the canonical ensemble. Subsequently, loci of con

The design and first results from a Double Sided Silicon Strip Detector (DSSSD) recently installed at the Lund Nuclear Microprobe facility (NMP) are presented. The detector has 64 sector strips and 32 ring strips, which in combination give more than 2000 detector cells, each with characteristics comparable with a standard surface barrier detector (SBD). The detector has been tested both with radio

Cerebral dopamine neurotrophic factor (CDNF) belongs to a newly discovered family of evolutionarily conserved neurotrophic factors.We demonstrate for the first time a therapeutic effect of CDNF in a unilateral 6-hydroxydopamine (6-OHDA) lesion model of Parkinson’s disease in marmoset monkeys. Furthermore, we tested the impact of high chronic doses of human recombinant CDNF on unlesionedmonkeys and

AIM: We assessed prevalence and location of pain in a total population of children and adolescents with cerebral palsy (CP) based on the Gross Motor Function Classification System (GMFCS), age and gender. METHODS: This cross-sectional study was based on the last assessment of children aged 1-14 years in the combined Swedish follow-up programme and national quality register programme for CP. All

There is a growing scientific consensus that limiting the increase in global average temperature to around 2 C above pre-industrial levels is necessary to avoid unacceptable impact on the climate system. This requires that the developed countries' emissions are radically reduced during the next 40 years. Energy scenario studies provide insights on the societal transitions that might be implied by

The aim of this study was to gain an enhanced understanding of how people with multiple sclerosis experience their occupational adaptation. Ten people with multiple sclerosis were interviewed and the constant comparative method was used to analyze the data. Their occupational adaptation was experienced as a constant struggle and non-linear, and served as the means of achieving either a desired sel

In recent years, climate impact assessments of relevance to the agricultural and forestry sectors have received considerable attention. Current ecosystem models commonly capture the effect of a warmer climate on biomass production, but they rarely sufficiently capture potential losses caused by pests, pathogens and extreme weather events. In addition, alternative management regimes may not be inte

The Italian Sarcoma Group and the Scandinavian Sarcoma Group designed a joint study to improve the prognosis for patients with Ewing's family tumors and synchronous metastatic disease limited to the lungs, or the pleura, or a single bone. The study was opened in 1999 and closed to the enrollment in 2008. The program consisted of intensive five-drug combination chemotherapy, surgery and/or radiothe

Institutional theory of the firm focuses on firm boundaries and the activities firms internalize within their hierarchies. However, an examination of disintegrated firms that influences activities beyond the scope of their hierarchies suggests that firms also perform other economic functions. By analysing these functions, the aim of this paper is to suggest a theory of the firm that goes beyond in

I denna artikel studeras metaforer i den svenska civilrätten med hjälp av en modern teori om metaforer – den kognitiva lingvistiken och dess undergrupp, den konceptuella metaforteorin. Syftet är att göra observationer av konceptuella metaforer och visa på metaforerna och deras underliggande tankestrukturers grundläggande betydelse för civilrättslig reglering, och vi använder oss därför av flera ex

Around 2000 persons are diagnosed with lymphoma in Sweden each year. There are many subgroups described for this form of cancer and the great majority is derived from B-cells. The most common subgroup is Diffuse large B-cell lymphoma (DLBCL), a highly aggressive disease where only half of the patients are cured. The lymphoma types seen in adults and children vary and the dominant form in children

Free radical polymerization of acrylate counterions to cationic alkyltrimethylammonium surfactant ions was performed in aqueous media. The results of the reactions were either formation, destruction or change of liquid crystalline surfactant structures, depending on the starting conditions such as the surfactant concentration, the content of inert counterions and the monomer-to-initiator ratio. Th

Hampton (1988) discovered that people are subject to overextension they categorize some things as falling under a conjunction (e.g., they categorize chess as a sport which is also a game) but not as falling under both of the corresponding conjuncts they do not categorize chess as a sport). Although subsequent literature has replicated this effect with a wider range of constructions than those orig

A common view is that an individual delinquent can be rehabilitated in a “home” in the countryside, away from his or her original urban social ties. An ironic result is new social ties with other juvenile delinquents as they spend a considerable amount of time together at a secluded institution. Drawing on ethnographic studies in residential care institutions, this article discusses two aspects to

Long--term intensive endurance training leads to increased left ventricular mass and increased left ventricular end--diastolic and left atrial end--systolic diameters. Different types of sports tend to give rise to distinct morphological forms of the athlete's heart. However, the sport--specific aspects have not been fully investigated in female athletes. The purpose of the present study was to in

CapsuleHouse Sparrow (Passer domesticus) populations in south Swedish farmland are not affected by supplemental winter feeding, irrespective of agricultural landscape type or presence of animal husbandry, although winter populations declined more in mixed farmland and when farms contained animal husbandry. AimsTo investigate whether food limitation of House Sparrow population size during the winte