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Diet-Induced Obesity Modulates Close-Packing of Triacylglycerols in Lipid Droplets of Adipose Tissue

Adipose-derived lipid droplets (LDs) are rich in triacylglycerols (TAGs), which regulate essential cellular processes, such as energy storage. Although TAG accumulation and LD expansion in adipocytes occur during obesity, how LDs dynamically package TAGs in response to excessive nutrients remains elusive. Here, we found that LD lipidomes display a remarkable increase in TAG acyl chain saturation u

An Evaluation of the Psychometric Properties of the Short Form of the Speech, Spatial and Qualities of Hearing Scale in Swedish : Online Versus Paper-and-Pen

PURPOSE: The purpose of this study was to examine the psychometric properties of the Swedish short form of the Speech, Spatial and Qualities of Hearing Scale (SSQ12) and investigate whether the paper-and-pen and online formats could be used interchangeably. METHOD: Individuals with and without hearing problems were invited to participate in this study. The participants (N = 125) were randomized in

Data-driven modelling of hydraulic-head time series : results and lessons learned from the 2022 Groundwater Time Series Modelling Challenge

This paper presents the results of the 2022 Groundwater Time Series Modelling Challenge, where 15 teams from different institutes applied various data-driven models to simulate hydraulic-head time series at four monitoring wells. Three of the wells were located in Europe and one was located in the USA in different hydrogeological settings in temperate, continental, or subarctic climates. Participa

International Criminal Law as a Catalyst for Environmental Peacebuilding

This paper examines the intersection of peace, justice and sustainability by exploring thepotential of international criminal law to contribute to environmental peacebuilding goals,which include sustainable governance of natural resources and cooperation to establishlasting peaceful relations within and between States. Despite the merits of existing stud-ies in shedding light on the concept of env

Expected features of the course leader in the rehabilitation healthcare professionals’ higher education : A qualitative study on students’ perspectives

Course leaders in rehabilitation healthcare professionals’ higher education face challenges stemming from multi-disciplinarity and the co-existence of different stakeholders. So far, the literature mainly attributed to course leaders’ managerial tasks, neglecting other fundamental transversal skills. Students represent an essential source of information for understanding the expected characteristi

Dissecting Dopaminergic Neuron Specification at Single Cell Resolution - Insights from 3D brain organoids and xenograft models

Midbrain dopaminergic neurons exhibit a wide diversity in their projection patterns, disease vulnerability, and functions, playing key roles in voluntary motor control, cognition, and reward processing. Parkinson’s Disease, one of the most common neurodegenerative disorders, is characterized by the selective degeneration of the A9 dopaminergic neuron subtype, leading to severe motor dysfunction. D

Identification and characterization of in vitro expanded hematopoietic stem cells

Hematopoietic stem cells (HSCs) cultured outside the body are the fundamental component of a wide range of cellular and gene therapies. Recent efforts have achieved > 200-fold expansion of functional HSCs, but their molecular characterization has not been possible since the majority of cells are non-HSCs and single cell-initiated cultures have substantial clone-to-clone variability. Using the Fgd5

Resolving the hematopoietic stem cell state by linking functional and molecular assays

One of the most challenging aspects of stem cell research is the reliance on retrospective assays for ascribing function. This is especially problematic for hematopoietic stem cell (HSC) research in which the current functional assay that formally establishes its HSC identity involves long-term serial transplantation assays that necessitate the destruction of the initial cell state many months bef

Lessons from early life : understanding development to expand stem cells and treat cancers

Haematopoietic stem cell (HSC) self-renewal is a process that is essential for the development and homeostasis of the blood system. Self-renewal expansion divisions, which create two daughter HSCs from a single parent HSC, can be harnessed to create large numbers of HSCs for a wide range of cell and gene therapies, but the same process is also a driver of the abnormal expansion of HSCs in diseases

Semi-Secular Worldviews and the Belief in Something Beyond

An increasingly large part of the population in the West identifies as religious Nones. Contrary to what might be assumed, most of them are not outright atheists. They reject traditional religion, but many pursue different forms of spirituality, and many entertain supernatural ideas. This element concerns the worldview of these “semi-secular” Nones. When asked about whether they believe in God, th

Underneath the peace: Shaolin monks’ views on the relationship between Buddhism and science

This study explores Buddhist monks’ views on the religion-science relationship in contemporary China. Drawing on survey data, interviews with monks, and participant observation within Shaolin Temple – famous for its antiquity and its export of Shaolin Kungfu – we discern and theoretically account for two forms of ‘non-conflict,’ between science and religion, that shape monks’ mental lives. One gro

Prevention som grund för samhället : Smittan och dess efterdyningar i dystopin Bärarna

Denna artikel analyserar Jessica Schiefauers spekulativa roman Bärarna (2020) och diskuterar konsekvenserna av att bygga ett samhälle utifrån smittoprevention. Romanen skildrar en framtid där en rabiesliknande sjukdom hotat att utplåna mänskligheten. I denna dystopi har män, som spridare av smittan, och kvinnor separerats för att förhindra återkomsten av sjukdomen. Artikeln undersöker hur romanen This article analyses Jessica Schiefauer’s speculative novel Bärarna (2020), and examines the consequences of building a society based on disease pre-vention. The novel depicts a future where a rabies-like disease has nearly wiped out humanity. In this dystopia, men, as carriers of the disease, are separated from women to prevent the resurgence of the illness. The article investigates how the nove

Där litterärt språk möter läkarspråk : Litteraturens potential för undervisning i medicinsk humaniora

This article discusses how fiction and its collisions between different linguistic registers have both literary and pedagogical potential. Taking its point of departure in literary texts used in the medical humanities teaching at the medical school at Lund University, various types of collisions between literary language and medical language are analysed. To conceptualize the collisions between th

Nurses' experiences of text-based digital triage at primary healthcare centres in Sweden : a qualitative interview study

BACKGROUND: Telehealth services are becoming increasingly popular at primary healthcare centres. Some examples include text-based digital triage and health guidance using chats, emails, images and pre-filled forms. Telephone-based communication has until recent years been the predominant means for triage and health guidance, but now includes written communication via computer or smartphone. Hence

Is Google Liberal on Immigration? : Attitude Bias, Politicization and Filter Bubbles in Search Engine Result Pages

Many conservative public figures have claimed that Google Search exhibits a liberal bias in the links presented. Surprisingly, perhaps, the few scientific studies conducted so far have tended to support this claim. In the study reported here, we compared Google search engine result pages (SERPs) for 8 terms related to immigration across 8 geographically distinct locations (municipalities). For eac

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Hjem (Home) is an exhibition showcasing the works of Sverre Bjertnæs, featuring around 40 paintings and sculptures, both old and new. The exhibition was curated by Fredrik Værslev in the spring of 2024. Bjertnæs is one of Norway's foremost painters and sculptors.