In their most extreme form, sex chromosomes exhibit a complete lack of genetic recombination along much of their length in the heterogametic sex. Some recent models explain the evolution of such suppressed recombination by the "sheltering"of deleterious mutations by chromosomal inversions that prevent recombination around a polymorphic locus controlling sex. This sheltering hypothesis is based on

Background: In breast cancer, several gene expression assays have been developed to provide a more personalised treatment. This study focuses on the prediction of two molecular proliferation signatures: an 11-gene proliferation score and the MKI67 proliferation marker gene. The aim was to assess whether these could be predicted from digital whole slide images (WSIs) using deep learning models. Met

The Schmidt number represents the genuine entanglement dimension of a bipartite quantum state. We derive simple criteria for the Schmidt number of a density matrix in arbitrary local dimensions, given that certain symmetric measurements exist. They are based on the trace norm of correlations obtained from seminal families of quantum measurements, specifically symmetric informationally complete mea

Denna avhandling är en sammanläggningsavhandling som utforskar möjligheterna att producera humanistisk samhällsvetenskap om "terrorism" och jihadism genom att använda queerteori, cripteori och affektteori. Den analyserar både jihadistiska gruppmedlemmar och sättet att producera kunskap om dessa ämnen. Genom att utmana reduktionistiska narrativ som framställer dessa individer som avvikande eller moThis dissertation is an article compilation thesis that explores the possibility of producing humanistic social science in general, using the case of conducting research on jihadist group members within the ‘War on Terror’ context. Empirically, the study employs first-hand interviews of jihadist group members in France. It finds that employing queer theory, crip theory, and affect theory to analyz

Objective Systemic sclerosis Impact of Disease (ScleroID) is the first comprehensive patient-reported outcome measure (PROM) specifically developed for systemic sclerosis (SSc). We investigated the performance of ScleroID in patients with diffuse cutaneous SSc (dcSSc), as a prerequisite for its use in randomised controlled trials (RCTs) testing potentially disease-modifying drugs. Methods All pati

Infants at elevated likelihood for or later diagnosed with autism typically have smaller vocabularies than their peers, as shown by the Mullen Scales of Early Learning (MSEL) and the MacArthur-Bates Communicative Developmental Inventory (CDI). However, the extent to which MSEL and CDI scores align remains unclear, especially across clinical and non-clinical populations. This study examined whether

Bioresorbable photonic implants are emerging as potential material choice for interstitial theranostic and monitoring applications. They gradually dissolve within the physiological environment in a clinically relevant period, eliminating the need for extraction surgeries. In the present study, we tested the suitability of in-house fabricated bioresorbable optical fibres based on calcium phosphate

With the current state of knowledge regarding disorders of facial bone development, including anodontia, the development of a suitable animal model for preclinical studies is essential. The agenesis of dental buds occurs in about 25% of the human population. Prospects for treatment include the use of growth factors, stem cells, and bioengineering. This study aimed to investigate the influence of a

Background: The objective of this paper was to estimate the impact of country-wide hospital pay-for-performance on readmissions for a set of common conditions in Lebanon. Methods: This retrospective cohort study included all hospitalizations under the coverage of the Ministry of Public Health in Lebanon between 2011 and 2019. We calculated 30-day all-cause readmissions following general, pneumonia

In this paper we propose minimal solvers for relative pose estimation for two views of the projected silhouettes of two 3D cylinders. Using such line features instead of the standard point feature correspondences means more stable information (i.e. more stable to lighting condition, seasons, changes in environment etc.). Such features also lead to more compact and semantically interpretable repres

Fano resonances are ubiquitous phenomena appearing in many fields of physics, e.g., atomic or molecular photoionization, or electron transport in quantum dots. Recently, attosecond interferometric techniques have been used to measure the amplitude and phase of photoelectron wave packets close to Fano resonances in argon and helium, allowing for the retrieval of the temporal dynamics of the photoio

Time delay estimation or Time-Difference-Of-Arrival estimates is a critical component for multiple localization applications such as multilateration, direction of arrival, and self-calibration. The task is to estimate the time difference between a signal arriving at two different sensors. For the audio sensor modality, most current systems are based on classical methods such as the Generalized Cro

This paper suggests an approach to solving the time-of-arrival self-calibration problem for imbalanced problems, where there is a low number of receivers but many senders. The idea is to solve several subproblems created by only using data relating to four receivers. The solutions are then clustered according to a proposed metric in order to remove failed reconstructions. They are then combined in

Rapid urbanization can change local climate by increasing land surface temperature (LST), particularly in metropolitan regions. This study uses two decades of remote sensing data to investigate how urbanization-induced changes in land use/land cover (LULC) affect LST in the Beijing Region, China. By focusing on the key issue of LST and its contributing variables through buffer zones, we determined

IMPORTANCE During the past decade, spinal surgical procedures have been increasingly performed on an ambulatory basis, a change in clinical practice supported only by observational evidence thus far. There have been no randomized clinical trials (RCTs) comparing ambulatory care with inpatient care after any spinal surgery. OBJECTIVE To assess whether ambulatory care is noninferior to overnight hos

Background: The use of welfare technology is gaining ground in municipal eldercare and is increasingly being integrated into everyday routines. However, the meanings that eldercare personnel attach to welfare technology in the care of older recipients, and thus the domestication of welfare technology, remain largely underexplored. This study explores how eldercare personnel understand and ascribe

Background: Right ventricular (RV) dyssynchrony or post systolic contraction (PSC) causes inefficient pumping and has not been investigated as a prognostic marker in pulmonary arterial hypertension (PAH). The objective was to investigate if RV dyssynchrony and PSC are prognostic markers of transplantation-free survival in PAH and if multiple RV views improve prognostication. Methods: Patients with