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Comparative Genomics of the Waterfowl Innate Immune System

Animal species differ considerably in their ability to fight off infections. Finding the genetic basis of these differences is not easy, as the immune response is comprised of a complex network of proteins that interact with one another to defend the body against infection. Here, we used population- and comparative genomics to study the evolutionary forces acting on the innate immune system in nat

Uptake of cervical cancer screening and its predictors among women of reproductive age in Gomma district, South West Ethiopia : a community-based cross-sectional study

Background: Cervical cancer is a public health challenge despite the available free screening service in Ethiopia. Early screening for cervical cancer significantly improves the chances of successful treatment of pre-cancers and cancers among women of reproductive age. Therefore, this study aimed to assess the uptake of screening and identify the factors among women of reproductive age. Methods: A

Futures of Fixing : Exploring the life of product users in circular economy repair society scenarios

A Circular Economy (CE) constitutes one pathway towards realising sustainable productionand consumption. Here, the repair of broken products (compared to replacement) consti-tutes an important strategy to keep products in the economy for longer, thereby reducingwaste, as well as the need to extract resources and emit pollution in the manufacture of areplacement product. In today’s world, repair do

Enrichment of Complement, Immunoglobulins, and Autoantibody Targets in the Proteome of Platelets from Patients with Systemic Lupus Erythematosus

Background Systemic lupus erythematosus (SLE) is a complex disease characterized by autoimmunity toward apoptotic cells, excessive amounts of circulating immune complexes, and complement activation. A decreased platelet size has been observed in SLE and their nonhemostatic functions may play an active role in the disease. The main objective of this study was to find clues that could explain their

The Organisation of Prayer Rooms in Educational Institutions in Denmark : Moderate Secularism Between Perception and Practice

In 2017, the Danish parliament discussed prayer rooms at educational institutions in a broadly publicised controversy. The debate followed a series of issues arising from such institutions’ changing demography, resulting in increased Muslim presence. Beneath the public and parliamentary debate in 2017, civil servants in ministries and educational institutions became highly engaged in negotiating w

Inflammatory cytokines and mechanical injury induce post-traumatic osteoarthritis-like changes in a human cartilage-bone-synovium microphysiological system

Background: Traumatic knee injuries in humans trigger an immediate increase in synovial fluid levels of inflammatory cytokines that accompany impact damage to joint tissues. We developed a human in vitro cartilage-bone-synovium (CBS) coculture model to study the role of mechanical injury and inflammation in the initiation of post-traumatic osteoarthritis (PTOA)-like disease. Methods: Osteochondral

Hampakalk : Tilläggsisolering på reveterade trähus och saltskadat tegelmurverk - Slutrapport

Historiska byggnaders energiprestanda behöver hållbart förbättras samtidigt som kulturhistoriska värden bevaras. Ett byggnadsmaterial som hampakalk skulle kunna uppfylla en ny funktion i renovering av historiska byggnader. Syftet var att finna en effektiv och resurssnål metod för tilläggsisolering av reveterade och putsade historiska trä- och tegelhus som är kompatibel med stommen, ökar energieffe

Prediction of Ki-67 expression of breast cancer with a multiparametric model using MRI parameters from ultrafast DCE-MRI and DWI

The purpose of this study is to investigate the prediction of Ki-67 expression of breast cancers using MRI parameters from ultrafast (UF) DCE-MRI, DWI, T2WI, and the lesion size. Breast MRI was performed with a 3T scanner using dedicated breast coils. UF DCE-MRI was obtained using Compressed Sensing-VIBE (prototype sequence). As a kinetic parameter of UF DCE-MRI, maximum slope (MS) was defined as

Following the Kinetics of Undercover Catalysis with APXPS and the Role of Hydrogen as an Intercalation Promoter

While improved catalytic properties of many surfaces covered by two-dimensional materials have been demonstrated, a detailed in situ picture of gas delivery, undercover reaction, and product removal from the confined space is lacking. Here, we demonstrate how a combination of gas pulses with varying compositions and time-resolved ambient pressure photoelectron spectroscopy can be used to obtain su

Causality and the fate of climate litigation : The role of the social superstructure narrative

Climate litigation has become a strategic tool to push for climate justice, including compensation for losses caused by climate change. Many cases rely on the establishment of a causal relationship between the defendants' emission of greenhouse gases (GHG) and the plaintiffs' losses. All decided cases seeking compensation for a concrete climate related impact have been unsuccessful (thus far). Leg

Structures of Atm1 provide insight into [2Fe-2S] cluster export from mitochondria

In eukaryotes, iron-sulfur clusters are essential cofactors for numerous physiological processes, but these clusters are primarily biosynthesized in mitochondria. Previous studies suggest mitochondrial ABCB7-type exporters are involved in maturation of cytosolic iron-sulfur proteins. However, the molecular mechanism for how the ABCB7-type exporters participate in this process remains elusive. Here

The UV Dose Used for Disinfection of Drinking Water in Sweden Inadequately Inactivates Enteric Virus with Double-Stranded Genomes

Irradiation with ultraviolet light (UV) at 254 nm is effective in inactivating a wide range of human pathogens. In Sweden, a UV dose of 400 J/m2 is often used for the treatment of drinking water. To investigate its effect on virus inactivation, enteric viruses with different genomic organizations were irradiated with three UV doses (400, 600, and 1000 J/m2), after which their viability on cell cul