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Operator auditory perception and spectral quantification of umbilical artery Doppler ultrasound signals

OBJECTIVE: An experienced sonographer can by listening to the Doppler audio signals perceive various timbres that distinguish different types of umbilical artery flow despite an unchanged pulsatility index (PI). Our aim was to develop an objective measure of the Doppler audio signals recorded from fetoplacental circulation in a sheep model.METHODS: Various degrees of pathological flow velocity wav

Minimal Solvers for Relative Pose with a Single Unknown Radial Distortion

In this paper, we study the problems of estimating relative pose between two cameras in the presence of radial distortion. Specifically, we consider minimal problems where one of the cameras has no or known radial distortion. There are three useful cases for this setup with a single unknown distortion: (i) fundamental matrix estimation where the two cameras are uncalibrated, (ii) essential matrix

Characterization of broadband few-cycle laser pulses with the d-scan technique

We present an analysis and demonstration of few-cycle ultrashort laser pulse characterization using second-harmonic dispersion scans and numerical phase retrieval algorithms. The sensitivity and robustness of this technique with respect to noise, measurement bandwidth and complexity of the measured pulses is discussed through numerical examples and experimental results. Using this technique, we su

Physicians' experiences with end-of-life decision-making: Survey in 6 European countries and Australia

Background: In this study we investigated (a) to what extent physicians have experience with performing a range of end-of-life decisions (ELDs), (b) if they have no experience with performing an ELD, would they be willing to do so under certain conditions and (c) which background characteristics are associated with having experience with/or being willing to make such ELDs. Methods: An anonymous qu

Molecular dynamics of NH3 induced by core-electron excitation

Nuclear motion in the N1s(-1)4a(1)(1) core-excited state of ammonia is investigated by studying the angular anisotropy of fragments produced in the decay of the highly excited molecule and compared with predictions from ab initio calculations. Two different fragmentation channels (H+/NH2+ and H+/NH+/H) reveal complex nuclear dynamics as the excitation photon energy is tuned through the 4a(1) reson

Realizing Lateral Wrap-Gated Nanowire FETs: Controlling Gate Length with Chemistry Rather than Lithography.

An important consideration in miniaturizing transistors is maximizing the coupling between the gate and the semiconductor channel. A nanowire with a coaxial metal gate provides optimal gate-channel coupling but has only been realized for vertically oriented nanowire transistors. We report a method for producing laterally oriented wrap-gated nanowire field-effect transistors that provides exquisite

Knockout of PARG110 confers resistance to cGMP-induced toxicity in mammalian photoreceptors.

Hereditary retinal degeneration (RD) relates to a heterogeneous group of blinding human diseases in which the light sensitive neurons of the retina, the photoreceptors, die. RD is currently untreatable and the underlying cellular mechanisms remain poorly understood. However, the activity of the enzyme poly-ADP-ribose polymerase-1 (PARP1) and excessive generation of poly-ADP-ribose (PAR) polymers i

Grain boundary influence during short fatigue crack growth using a discrete dislocation technique

We have studied the effect of a grain boundary in front of a short edge crack on its propagation under cyclic loading conditions in bcc iron. The used model is a combination of a discrete dislocation formulation and a boundary element approach where the boundary is described by dislocation dipole elements, while the local plasticity is modeled by discrete dislocations. The grain boundary is consid

EULAR recommendations for vaccination in adult patients with autoimmune inflammatory rheumatic diseases

Objectives To develop evidence-based European League Against Rheumatism (EULAR) recommendations for vaccination in patients with autoimmune inflammatory rheumatic diseases (AIIRD). Methods A EULAR task force was composed of experts representing 11 European countries, consisting of eight rheumatologists, four clinical immunologists, one rheumatologist/clinical immunologist, one infectious disease p

'No Man is an Island': Why the 'solitary genius' is too narrow an approach to creativity in a digital context

This article focuses on the perception of creativity found in copyright law, which conflicts with the ways in which creativity seems to develop in daily practice; the idea of a “solitary genius” is, thus, contrasted to that of a contextually and culturally dependent creator. Copyright is arguably too focused on the former image and fails to acknowledge or embrace the latter. In addition, the digit

The effects of background white noise on memory performance in inattentive school children

Abstract Background: Noise is typically conceived of as being detrimental for cognitive performance; however, a recent computational model based on the concepts of stochastic resonance and dopamine related internal noise postulates that a moderate amount of auditive noise benefit individuals in hypodopaminergic states. On the basis of this model we predicted that inattentive children would be enha

Phthalate diesters and their metabolites in human breast milk, blood or serum, and urine as biomarkers of exposure in vulnerable populations

BACKGROUND: Phthalates may pose a risk for perinatal developmental effects. An important question relates to the choice of suitable biological matrices for assessing exposure during this period. OBJECTIVES: This study was designed to measure the concentrations of phthalate diesters or their metabolites in breast milk, blood or serum, and urine and to evaluate their suitability for assessing perina

Quality and lean health care: a system for assessing and improving the health of healthcare organisations

The purpose of this article is to present and discuss the development of a system for assessing and improving healthcare organisations. The system components comprise (1) a framework or model for assessing, measuring, diagnosing and improving healthcare organisations, (2) a simple methodology for data collection, data analysis and prioritising improvement areas and (3) an index named ILL (innovati

Cytogenetic abnormalities in Acute Myeloid Leukemia in Sweden. A population based study.

The impact of cytogenetic findings in AML was analyzed in the large population-based Swedish AML registry. Karyotypic patterns differed by age: t(8;21), inv(16) and t(11q23) were more common in younger patients, whereas loss of 5q, 7q and 17p, monosomal karyotype (MK) and complex karyotype (CK) were more common in older patients. Patients with ≥5 chromosome abnormalities had worse overall survival

Global profiling of metabolic adaptation to hypoxic stress in human glioblastoma cells.

Oncogenetic events and unique phenomena of the tumor microenvironment together induce adaptive metabolic responses that may offer new diagnostic tools and therapeutic targets of cancer. Hypoxia, or low oxygen tension, represents a well-established and universal feature of the tumor microenvironment and has been linked to increased tumor aggressiveness as well as resistance to conventional oncologi

Serum Estradiol Levels Are Inversely Associated With Cortical Porosity in Older Men

Context: The key role of serum estradiol (E2) for bone health in men is well established. The effect of serum sex steroids on bone microstructure, measured by high-resolution peripheral quantitative computed tomography, remains unknown in elderly men. Objective: The objective of the study was to examine the associations between serum sex steroids and bone microstructural parameters in older men. M