Several studies have revealed links between hypoxia and activation of Notch in solid tumors. While most reports have focused on icN1 stabilization by direct interaction with HIF proteins, little attention has been given to Notch ligand regulation during hypoxia. Here we show that the Notch ligand JAG2 is transcriptionally activated by hypoxia in a HIF-1α dependent manner. Hypoxic JAG2 induction re

Understanding the spatiotemporal distribution of birds is crucial for effective management and conservation of their populations. However, we still have only limited knowledge not only of the wintering destinations of many Iberian breeding migrants but also of aspects as general as the migratory behaviour of the populations of many common avian species that breed in the Iberian highlands. We used

Popular Abstract in Danish Med udgangspunkt i et kompetenceudviklingsprojekt for lærere i en svensk kommune adresserer denne afhandling de stigende krav til forandring og innovation, der karakteriserer den offentlige sektor generelt. Ved at følge kompetenceudviklingsprojektet gennem en fire-årig periode sættes projektet i en kontekst af innovation, globalisering og forandring. Forfatteren argumentThis dissertation critically analyses the discourse on educational change. By placing educational change in the context of globalisation and innovation the author argues that the current discourse on educational change is un-nuanced and omits the important perspectives on change. The author has analysed an educational district in Sweden and one of its projects on competence development, named 'Str

Background: Fibrinogen concentrate treatment can improve coagulation during massive traumatic bleeding. The aim of this in vitro study was to determine whether fibrinogen concentrate, or a combination of factor XIII and fibrinogen concentrates, could reverse a haemodilution-induced coagulopathy during hypothermia. Methods: Citrated venous blood from 10 healthy volunteers was diluted in vitro by 33

This paper deals with organizational inscriptions of managerial cognitions elaborating on the emerging concept of network pictures. While previous studies on network pictures have concentrated on individual managers' cognitive views of business networks, this study operates on a focal company level (meso-level) and is concerned with how managerial cognitions are manifested in organizational artifa

Chymosin-induced gelation properties of the milk of around 400 Swedish Red dairy cows was investigated with the aim of identifying genetic protein variants that influence chymosin-induced gelation for optimisation of cheese milk through breeding practices. The variation in chymosin-induced gelation properties was shown to be large in the milk of Swedish Red and there was a high frequency of cows p

Falling in old age may have a large impact on daily life. Falls can lead to injuries, reduced mobility and reduced quality of life. The risk of falls increases with age and frailty level. Dizziness is a strong risk factor for falls, and preventing falls and dizziness in older people is essential. The overall aim of this thesis was to investigate risk factors for falls or dizziness and to explore o

The objective of this paper is to provide a general account of value relations. But it takes its departure is a special type of value relation, parity. The notion of parity is due to Ruth Chang. According to her, two items may be evaluatively comparable even when neither is better than, worse than, or equally good as the other. There is a fourth kind of comparability: being on a par. Recently, Jos

Seabirds act as vectors transporting marine nutrients to land by feeding on fish while nesting and roosting on islands. By depositing large amounts of nutrient-rich guano on their nesting islands they strongly affect island soils, vegetation and consumers. However, few studies have investigated how nesting seabirds affect soil communities. In this study, we investigated how cormorant nesting colon

We review some new literature on diatoms, with emphasis on genomics, evolution, ecology and biomimetic nanotechnical applications. Diatoms account for a substantial part of the photosynthetic production on this planet, and their genome is a mosaic of contributions from different sources. They occupy very diverse ecological niches, and may have been the first organisms to carry out C4 photosynthesi

Popular Abstract in Swedish Barn ar ofta bärare av luftvägsbakterien pneumokocker i de övre luftvägarna och det är barnen som anses vara den största reservoaren för bakterien i vårt samhälle. Vanliga pneumokockinfektioner såsom öron-, bihåle- eller lunginflammation föregås av att man bär på bakterien. De flesta barn som är bärare blir dock inte sjuka. Vuxna är mer sällan bärare av bakterien. PneuThe paediatric nasopharyngeal flora is regarded as the largest reservoir for Streptococcus pneumoniae, and the carrier state is always antecedent to infection and a prerequisite for dispersion of these bacteria. Pneumococci are the predominant aetiology of bacterial respiratory tract infections and a major cause of morbidity and mortality, in the most severe cases due to invasive pneumococcal dise

Multi-user MIMO offers big advantages over conventional point-to-point MIMO: it works with cheap single-antenna terminals, a rich scattering environment is not required, and resource allocation is simplified because every active terminal utilizes all of the time-frequency bins. However, multi-user MIMO, as originally envisioned, with roughly equal numbers of service antennas and terminals and freq

In this Note we present a complete solution to the problem of multifractal analysis of multiple ergodic averages in the case of symbolic dynamics for functions of two variables depending on the first coordinate. (C) 2011 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved.