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Background. Treatment of childhood medulloblastoma has evolved to reduce neurotoxicity while improving survival. However, the impact of evolving therapies on late neurocognitive outcomes and adult functional independence remains unknown. Methods. Adult survivors of childhood medulloblastoma (n = 505; median [minimum–maximum] age, 29 [18–46] years) and sibling controls (n = 727; 32 [18–58] years) f
Background and aims: Gallstone disease during pregnancy can have varying consequences, from mild to severe and even life-threatening. The aim was to investigate how gallstone intervention during pregnancy impacts pregnancy, delivery and the newborn child. Methods: Pregnant patients 18–45 years identified from the Swedish National Register for Gallstone Surgery and Endoscopic Retrograde Cholangiopa
Brain amyloid-β (Aβ) pathology is a core feature of Alzheimer disease (AD) and can be quantified using positron emission tomography (PET). Cerebrospinal fluid (CSF) and plasma biomarkers detect abnormal Aβ, but it is unclear to what degree they can predict quantitative Aβ-PET. We explored plasma and CSF biomarkers in relation to Aβ-PET in the BioFINDER-2 study (N = 1053), and the BioFINDER-1 study
Objective: Synovial fluid contains proteins that may have been released from surrounding tissues, our aim was to gain new insights into the proteomic profiles of human synovial fluid in knees with and without osteoarthritis (OA). Methods: We used synovial fluid from 11 patients with end-stage medial compartment knee OA, aspirated during total knee replacement, and from 13 deceased donors who had n
Objective: To evaluate the effects of excluding fatty tissue in QSM of human knee cartilage. Materials and methods: Gradient echo images from 18 knee-healthy volunteers were acquired, from which chemical shift corrected field perturbation maps were calculated. Based on these, QSM maps were reconstructed using morphology enabled dipole inversion and one of three masking alternatives: (1) excluding
Background: Low adherence to lipid-lowering therapy (LLT) after myocardial infarction (MI) is associated with increased risk of recurrent cardiovascular events and death. However, little is known about long-term adherence patterns following treatment interruptions. The aim of this study was to describe adherence trajectories in MI patients following a LLT treatment gap, and model the impact of dif
Organoid systems hold promise as miniaturized in vitro platforms that model developmental and pathological processes. However, the engineering of human bone marrow organoids (BMOs) has been a long-standing challenge. Recently, the field has witnessed the emergence of BMO-like systems, a potential paradigm shift for the study of human hematopoiesis and associated niche elements. Published protocols
Background: Continuity of care (CoC) is essential for effective primary health care (PHC), yet Swedish PHC has historically exhibited low levels of continuity. The Swedish Patient Choice Reform introduced privatization and market-oriented principles into PHC, leading to increased utilization and growing inequities in service use driven by socioeconomic disparities and misalignment with health care
Background Preserved ratio impaired spirometry (PRISm) is a spirometry pattern of interest regarding incident airflow obstruction and higher mortality risk. We applied a proteomic approach to gain more insight into the biological mechanisms associated with PRISm. Methods From the population-based Swedish Cardiopulmonary Bioimage Study (SCAPIS), participants in the Main (n=4835) and Pilot (n=1054)
Vaccine hesitancy and anti-vaccination attitudes are becoming increasingly problematic in several Western countries where diseases that were nearly extinct are coming back. We here explore the role of perceived social support in understanding anti-vaccination attitudes. We argue that perceptions about having social support for one′s position may influence anti-vaccination attitudes among some soci
We analyze the stability of the logit evolutionary dynamics in population games, possibly with multiple heterogeneous populations. For general population games, we prove that, on the one hand, strict Nash equilibria are asymptotically stable under the logit dynamics for low enough noise levels, on the other hand, a globally exponentially stable logit equilibrium exists for sufficiently large noise
Many companies leverage the creativity of their employees to gather ideas for innovations. These ideas are collected, saved, and evaluated via platforms known as corporate ideation systems. Moderated ideation systems (ideation 2.0) emerged as a solution to address the limitations of traditional, rather passive ideation systems (ideation 1.0). In this study, we apply a qualitative mixed-method appr
Heart and lung transplantation remain the primary treatments for end-stage organ failure; yet organ shortages and ischemia-reperfusion injury (IRI) limit their success. Extended criteria donors (ECDs) have expanded the donor pool; however, prolonged cold ischemia times increase the risk of primary graft dysfunction (PGD). Static cold storage (SCS), the standard organ preservation method, is subopt
Embodiment has slowly been integrated as a category of analysis in (critical) military studies. In this article, we argue that embodiment–and related concepts such as body, affects and emotions–has become prevalent concerns over the 10-year consolidation of the intellectual project of the journal CMS. We propose an inquiry organized around three axes: situating current debates in the broader field
Cyanobacteria are bioactive compounds that produce toxins known as harmful algal blooms, posing serious threats to humans and marine life. Consequently, developing a robust monitoring framework to track and forecast the growth of such blooms is critical. The present work aims to understand the key environmental drivers influencing cyanobacterial bloom dynamics along the Southeast coast of India us
This letter addresses loss of packets in a wireless fronthaul link being interpreted as channel errors for the service link. This may occur if, for instance, User Equipment (UE) is served by a radio unit in an Uncrewed Aerial Vehicle (UAV) via a wireless fronthaul link to a baseband unit (BU) on the ground. The fronthaul packet loss leads to a mismatch between the real and estimated channel state,
This study investigates properties of mastics produced with 70/100 neat bitumen, three mineral fillers (granite, quartz-granite, and diorite), and a lime-based active filler at filler-to-bitumen (F/B) ratios of 40%, 50%, and 60%. The physical, geometrical, and mineralogical properties of the fillers were assessed. Their influence on mastics' behaviour was evaluated using conventional penetration a
This study aims to explore the mechanism through which Yishen Jiangtang Decoction (YSJTD) regulates endoplasmic reticulum stress (ERS)-mediated NOD-like receptor thermal protein domain associated protein 3 (NLRP3) inflammasome to improve diabetic nephropathy (DN) in db/ db mice. Thirty db/ db mice were randomly divided into the model group, YSJTD group, ERS inhibitor 4-phenylbutyric acid (4-PBA) g
