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Studies on chondrocyte integrins and mechanical signaling

Popular Abstract in Swedish Brosk är en typ av vävnad som finns på många olika ställen i vår kropp. Karakteristiskt för brosk är att det är mycket hållfast samtidigt som det medger en hög grad av flexibilitet. Ledbrosket är det tunna brosklager som klär kortändarna på benen i skelettet. Dess uppgift i leden är att fungera som stötdämpare för att skydda det underliggande benet samt att utgöra den gIntegrins are a family of cell surface receptors known to bind matrix proteins and to mediate signals such as mechanical signals between the cell and the surrounding matrix. We have studied integrins that are expressed by chondrocytes, with specific focus on the integrins that interact with the cartilage matrix protein collagen type II. It was found that chondrocytes isolated from articular cartil

Structural and physicochemical studies on metal and porphyrin binding by the Bacillus subtilis ferrochelatase

The enzyme ferrochelatase (EC 4.99.1.1) is the terminal enzyme in the biosynthetic pathway of heme b and catalyzes the insertion of Fe(II) into protoporphyrin IX. In this dissertation ferrochelatase from Bacillus subtilis was studied. A new purification method via inclusion bodies was developed that enabled simple purification of recombinant enzyme without tags or modifications that might affect t

Redesign of an Electrical Rear Wheel Drive (E-RWD) for a hybrid vehicle in a given drive cycle

This article presents the redesign of a traction motor of an Electrical Rear Wheel Drive (E-RWD) unit, modifying its torque and power capabilities in order to improve the vehicle efficiency with given drive cycles in a hybrid vehicle application. It is shown that a peak-to-average power ratio of 3 is suitable and that this is best accomplished with a reduced slot area in combination with cooling d

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Abstract in German Grundlegende Daten zur Beurteilung der thermischen Beanspruchung während der Arbeit in Schutzkleidung wurden im europäischen Verbundprojekt THERMPROTECT (EU Contract-No. G6RD-CT-2002-00846) mit Untersuchungen des durch die Kleidung erhöhten Energieumsatzes und des Transports von Wärme und Feuchte unter Kältebelastung sowie bei Einwirkung von Wärmestrahlung erhoben. Der Eingang d

Storytelling in Jazz Improvisation : Implications of a Rich Intermedial Metaphor

The phenomenon of intermedial conceptual loans is central to our understanding of the time-based arts. This thesis focuses on the usage of the term storytelling with regard to jazz improvisation. The aim of the investigation is to clarify how this concept is used by Swedish jazz practitioners. The framework of the study includes theories of narrativity and of metaphor as well as educational and