Nonheme iron enzymes play an important role in the aerobic degradation of aromatic ring systems. Most enzymes can only cleave substrates with electron-rich substituents, e.g., with two hydroxyl groups. However, salicylate 1,2-dioxygenase (SDO) can cleave rings with only a single hydroxyl group. We investigated the oxygen-activation mechanism of the ring fission of salicylate by SDO by computationa

Purpose: The aim of this study was to describe experiences of attitudes in the society of Sierra Leone from the perspective of individuals with poliomyelitis and people with amputations using orthotic or prosthetic devices. Methods: Individual interviews were conducted using open-ended questions. Twelve participants with amputations or polio were included. Content analysis was applied to the data.

The current paper draws on data generated through group interviews with students who were involved in a larger ethnographic research project performed in three science classrooms. The purpose of the study from which this data was generated, was to understand science teachers’ assessment practices in an upper-secondary school in Sweden. During group interviews students were asked about their concep

Cancer-associated fibroblasts (CAFs) interact with tumour cells and promote growth and metastasis. Here, we show that CAF activation is reversible: chronic hypoxia deactivates CAFs, resulting in the loss of contractile force, reduced remodelling of the surrounding extracellular matrix and, ultimately, impaired CAF-mediated cancer cell invasion. Hypoxia inhibits prolyl hydroxylase domain protein 2

The contractile actomyosin cytoskeleton and its connection to the plasma membrane are critical for control of cell shape and migration. We identify three STRIPAK complex components, FAM40A, FAM40B and STRN3, as regulators of the actomyosin cortex. We show that FAM40A negatively regulates the MST3 and MST4 kinases, which promote the co-localization of the contractile actomyosin machinery with the E

Parabolic sub-sample interpolation for 2D block-matching motion estimation is computationally efficient. However, it is well known that the parabolic interpolation gives a biased motion estimate for displacements greater than |y.2| samples (y = 0, 1, …). Grid slope sub-sample interpolation is less biased, but it shows large variability for displacements close to y.0. We therefore propose to combin

We have mimicked the biofilm formation with highly stable biocompatible poly(2-methyl-2-oxazoline)-based polymersomes by simple spreading-drying of a droplet of the sample solution onto a glass support. The diffusion-limited aggregation process of polymersomes onto the surface was analyzed within a fractal framework. The different examples analyzed and presented together indicate one means by whic

Large volumes of data from satellite sensors with high time-resolution exist today, e.g. Advanced Very High Resolution Radiometer (AVHRR) and Moderate Resolution Imaging Spectroradiometer (MODIS), calling for efficient data processing methods. TIMESAT is a free software package for processing satellite time-series data in order to investigate problems related to global change and monitoring of veg

This paper investigates the multiple windows of the mean squared error optimal time-frequency kernel for estimation of the Wigner-Ville spectrum. The kernel is optimal for a certain locally stationary process where the covariance function is determined by two one-dimensional Gaussian functions. The multiple windows are obtained as the eigenvectors of the rotated time-lag estimation kernel. The spe

A cross-national study, 49 samples in 38 nations, N=4,344, investigates whether national peace and conflict reflect ambivalentwarmth-competence stereotypes: High-conflict societies (Pakistan)may need clearcut, unambivalent group images-distinguishingfriends from foes. Highly peaceful countries (Denmark) also mayneed less ambivalence because most groups occupy the sharednational identity, with onlyA cross-national study, 49 samples in 38 nations, N=4,344, investigates whether national peace and conflict reflect ambivalent warmth-competence stereotypes: High-conflict societies (Pakistan) may need clearcut, unambivalent group images-distinguishing friends from foes. Highly peaceful countries (Denmark) also may need less ambivalence because most groups occupy the shared national identity, with

To improve the dexterity of multi-functional myoelectric prosthetic hand, more accurate hand gesture recognition based on surface electromyographic (sEMG) signal is needed. This paper evaluates two types of time-domain EMG features, one independent feature and one combined feature including four features. The selected features from eight subjects with 13 finger movements were tested with four deco

Background: The aim was to evaluate the influence of smoking and preoperative electrophysiology on the outcome of open carpal tunnel release. Methods: This retrospective observational study evaluated the outcome in 493 patients (531 hands) primary operated for carpal tunnel syndrome. Data were collected from medical records, health evaluations, and QuickDASH questionnaires before surgery and 1 yea

Background: Lifestyle factors may influence the risk of developing pancreatic cancer. Whereas cigarette smoking is an established risk factor, the effects of high alcohol intake and obesity are more uncertain. The aim of the present study was to examine the associations of pre-diagnostic anthropometry, alcohol consumption, and smoking habits with pancreatic cancer risk in a Swedish prospective, po