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Apolipoprotein E4 (ApoE4) is the most important genetic risk factor for Alzheimer's disease (AD). Among the earliest changes in AD is endosomal enlargement in neurons, which was reported as enhanced in ApoE4 carriers. ApoE is thought to be internalized into endosomes of neurons, whereas β-amyloid (Aβ) accumulates within neuronal endosomes early in AD. However, it remains unknown whether ApoE and A
BACKGROUND: Amyloid-β (Aβ) is a normal product of neuronal activity, including that of the aggregation-prone Aβ42 variant that is thought to cause Alzheimer's disease (AD). Much knowledge about AD comes from studies of transgenic rodents expressing mutated human amyloid-β protein precursor (AβPP) to increase Aβ production or the Aβ42/40 ratio. Yet, little is known about the normal expression of Aβ
OBJECTIVE: Salt-inducible kinase 2 (SIK2) is abundantly expressed in adipocytes and downregulated in adipose tissue from individuals with obesity or insulin resistance. The main aims of this work were to investigate the involvement of SIKs in the regulation of glucose uptake in primary mature human adipocytes and to identify mechanisms underlying this regulation.METHODS: Primary mature adipocytes
This article describes, discusses, and evaluates an educational program aimed at building resilience in public libraries. The program focuses on personal and organizational resilience and builds upon four themes: trust, stress and uncertainty, group identity, and character-strengths. Eighty-seven Swedish public library professionals participated in it. A mixed-method approach was used to study how
BACKGROUND: Integration of oncology and palliative care has been shown to increase quality of life in advanced disease. To meet the needs of the growing older population, integration of palliative care and geriatrics has been proposed but scarcely described.OBJECTIVES: The aim of this study was to integrate palliative care into geriatrics by a structured care guide, the Swedish Palliative Care Gui
Trauma is a highly topical subject of growing relevance in different contexts and scientific traditions that deal with societal challenges and transformation. At the same time, knowledge on different understandings of trauma is still scarce and scattered across disciplines. Against this background, we present and discuss the complexity of trauma understandings from five selected disciplinary persp
Objective: Two predominant phenotypic models of causality exist to explain the high co-occurrence of posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD): the self-medication and susceptibility models. Population-based longitudinal studies that simultaneously examine both models are needed. Thus, the goal of the pres-ent study is to test these models using the Swedish National Regis
Background The authors sought to clarify the impact of spousal psychiatric disorders of differing severity [major depression or anxiety disorders (DAD) v. bipolar disorder or nonaffective psychosis (BPN)] on proband risk for alcohol use disorder (AUD) during marriage. Methods In a Swedish cohort (N = 744 628), associations between spousal DAD and BPN and proband AUD were estimated with Cox proport
The research study focuses on the application of Soft Systems Methodology (SSM) to develop a collaborative user-centered approach within the context of organizational learning, and concludes with suggestions of further research. More specifically, it explores library users’ and academic librarians’ ideal characteristics for the library discovery and access services mediated through the Online Publ
Kommuner och regioner är tillförsäkrade självstyre under riksdagen och regeringen. Självstyrelsen manifesteras av den kommunala rösträtten och den kommunala beskattningsrätten. På en rad sakområden har riksdagen i lag ålagt kommunerna att göra samhällsinsatser, en del av dem finansierade av riksdagen. Kommunerna och regionerna har därmed den rättsliga ställningen som demokratins verkställande orga
It is widely known that nanoparticle seeded growth of III-V semiconductor nanowires often occurs via the vapor-liquid-solid mechanism. However, conventional growth of nanowires is carried out in closed systems, where mostof the details and dynamics of the growth are impossible to follow. Since all analysis is typically carried out after growth completion and transfer, only the trends in the produc
Several nanowire properties are strongly dependent on their diameter, which is notoriously difficult to control for III–Sb nanowires compared with other III–V nanowires. Herein environmental transmission electron microscopy is utilized to study the growth of Au nanoparticle seeded GaSb nanowires in situ. In this study, the real time changes to morphology and nanoparticle composition as a result of
Cryptophycins are naturally occurring cytotoxins with great potential for chemotherapy. Since targeted therapy provides new perspectives for treatment of cancer, new potent analogues of cytotoxic agents containing functional groups for conjugation to homing devices are required. We describe the design, synthesis and biological evaluation of three new unit B cryptophycin analogues. The O-methyl gro
