Recent large-scale cDNA cloning studies have shown that a significant proportion of the transcripts expressed from vertebrate genomes do not appear to encode protein. Moreover, it was reported in mammals (human and mice) that these non-coding transcripts are expressed and regulated by mechanisms similar to those involved in the control of protein-coding genes. We have produced a collection of cDNA

The welding of dissimilar alloys is seen increasingly as a way forward to improve efficiencies in modern aeroengines, because it allows one to tailor varying material property demands across a component. Dissimilar inertia friction welding (IFW) of two high-strength steels, Aermet 100 and S/CMV, has been identified as a possible joint for rotating gas turbine components and the resulting welds are

The usage of industrial robots for milling tasks is limited by their lack of absolute accuracy in presence of process forces. While there are techniques and products available for increasing the absolute accuracy of free-space motions, the mechanical weaknesses of the robot in combination with the milling forces limits the achievable performance. If the dynamic effects causing the deviations can b

Investigations of past fires suggest that building occupants faced with a fire have problems defining the severity of it, especially in the early stages of the fire. An experiment was therefore carried out to study people’s ability to estimate fire growth, and their perceived ability to extinguish a fire using a portable fire extinguisher. A total of 535 persons, namely 304 men and 231 women, were

Popular Abstract in Swedish Njurfunktion inom hjärtkirurgi Akut njursvikt (AKI) efter hjärtkirurgi är en allvarlig komplikation som förekommer i 25-35 % av alla patientfall. AKI medför förhöjd risk för allvarliga komplikationer och död efter hjärtkirurgi. Ett stort fokus ligger på detektion, prevention och behandling av AKI och forskningsfältet uppdateras kontinuerligt. En rad olika läkemedel har Abstract Acute kidney injury (AKI) is a common and serious complication after cardiothoracic surgery and is associated with increased short- and long-term mortality risk. Despite extensive studies in the field, a comprehensive understanding of this syndrome has remained elusive, partly due to divergent definitions of AKI and partly due to the limitations of available routine biomarkers to predict,

Highly transparent, conductive Sn-doped In2O3 (ITO) thin films with a characteristic root mean square surface roughness RMS below 1 nm were obtained from deposition of amorphous ITO and subsequent annealing treatment. ITO thin films with ultra flat surface were produced by (i) controlling crystallization mechanisms (nucleation and growth) of amorphous ITO through optimization of hydrogen content a

The focus of this article is on exploring craft expertise and its potential as a factor in aggrandizer strategies. It is argued that there are elements of natural aptitude which enabled certain individuals to excel at flintknapping, allowing them to create objects of exceptional size and beauty in acts of elaborate knapping. Practice alone will enable an individual to reach a certain level of prof

Serum amyloid P component (SAP) belongs to the pentraxin family of proteins, members of which are characterized by radial pentameric structure and calcium-dependent ligand binding. SAP is present in all types of amyloidosis and has been shown to bind to several ligands, but the physiological function of this protein has not been fully elucidated. The present study identified and characterized SAP

Non-alcoholic fatty liver disease (NAFLD), obesity and type 2 diabetes(T2D) are strongly associated and today their prevalence reaches epidemic proportions. NAFLD has a multi-factorial aetiology, both genetic and environmental factors are equally important. The aim of this thesis was to investigate genetic factors associating with NAFLD and circulating triglyceride (TG) levels in overweight or obe

Intervju med Eric Clark

Precise measurements of the lifetimes of the first excited 2(+) states in the stable even-A Sn isotopes Sn112-124 have been performed using the Doppler shift attenuation technique. For the isotopes Sn-112, Sn-114 and Sn-116 the E2 transition strengths deduced from the measured lifetimes are in disagreement with the previously reported values and indicate a shallow minimum at N = 66. The observed d

In many materials it remains a challenge to reveal the nature of magnetic correlations, including antiferromagnetism and spin disorder. Revealing the spin structure in magnetic nanoparticles is further complicated by the large incoherent neutron scattering cross section from water adsorbed at the particle surfaces and by the broadening of diffraction peaks due to the finite crystallite size. Moreo

We propose and demonstrate a new approach for the simulation of woody ecosystem stand dynamics, demography, and disturbance-mediated heterogeneity suitable for continental to global applications and designed for coupling to the terrestrial ecosystem component of any earth system model. The approach is encoded in a model called Populations-Order-Physiology (POP). We demonstrate the behavior and per

The hyaluronan (HA)-rich pericellular coat (PCC) enveloping most mammalian cells plays a vital role in biological processes such as cell adhesion, proliferation, motility and embryogenesis. In particular its presence on chondrocytes, which live in the load-bearing cartilage, has a wide range of implications in diseases such as osteoarthritis, highlighting its mechanical role in living organisms. D

Glucocorticoids play a role in the origin of the features of the metabolic diseases. Alpha-ketoglutarate (AKG) is defined as glutamine homologue and derivative, conditionally an essential amino acid. In the liver, glutamine serves as a precursor for ureagenesis, gluconeogenesis and acute phase protein synthesis The aim of the study was to determine the effect of AKG administered to piglets prenata

Background: The aim of this study was to investigate the association of sex hormone-binding globulin (SHBG) and hypertension in a Swedish population. Methods: The study is based on a random sample of a Swedish population of men and women aged 30-74 years (n=2,816). Total testosterone, oestradiol and SHBG were measured in 2,782 participants. Free androgen index was then calculated according to the