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Quality Improvement Initiatives in Fragility Fracture Care and Prevention

Purpose of Review: This review sought to describe quality improvement initiatives in fragility fracture care and prevention. Recent Findings: A major care gap persists throughout the world in the secondary prevention of fragility fractures. Systematic reviews have confirmed that the Fracture Liaison Service (FLS) model of care is associated with significant improvements in rates of bone mineral de

Day Fines in Sweden

As in other areas of social engineering, Sweden is considered as world-leading in creating systems that address social inequality. One of the cases in point is the Swedish day-fine system which has been considered as pioneering by systematically considering both the wealth of the offender and the seriousness of the offence when imposing the penalty. This chapter analyses in detail the Swedish day-

Outsourcing Public Services: Contractibility, Cost, and Quality

We review the literature on public sector outsourcing to explore if the theoretical predictions from the incomplete contracts literature hold up to recent empirical evidence. Guided by theory, we arrange services according to the type and magnitude of their contractibility problems. The empirical studies point at rather favourable outsourcing outcomes, in terms of costs and quality, for services w

Glucose-dependent insulinotropic peptide and risk of cardiovascular events and mortality : a prospective study

AIMS/HYPOTHESIS: Evidence that glucose-dependent insulinotropic peptide (GIP) and/or the GIP receptor (GIPR) are involved in cardiovascular biology is emerging. We hypothesised that GIP has untoward effects on cardiovascular biology, in contrast to glucagon-like peptide 1 (GLP-1), and therefore investigated the effects of GIP and GLP-1 concentrations on cardiovascular disease (CVD) and mortality r

Substantial intrinsic variability in chemoradiosensitivity of newly established anaplastic thyroid cancer cell-lines

Background: Well characterized human cell lines are needed for preclinical treatment studies of anaplastic thyroid cancer (ATC).Aims/Objectives: The aim was to establish, verify and characterize a panel of ATC cell lines.Material and methods: Cell lines were established from ATC fine-needle aspiration biopsies and characterized genetically and functionally regarding treatment sensitivities.Results

Tÿcho : A framework for compiling stream programs

Many application areas for embedded systems, such as DSP, media coding, and image processing, are based on stream processing. Stream programs in these areas are often naturally described as graphs, where nodes are computational kernels that send data over the edges. This structure also exhibits large amounts of concurrency, because the kernels can execute independently as long as there are data to

Protein recovery from rapeseed press cake : Varietal and processing condition effects on yield, emulsifying capacity and antioxidant activity of the protein rich extract

Protein was recovered from five varieties and a mixed blend of cold-pressed rapeseed press cake by leaching and precipitation in a water-based process, and the protein recovery yield varied from 26–41% depending on variety. Exposure for heat during protein recovery severely reduced the rapeseed proteins’ ability to stabilize the oil–water interface of emulsion droplets. Protein extract from Lyside

Measurement of angular and momentum distributions of charged particles within and around jets in Pb+Pb and pp collisions at sNN =5.02 TeV with the ATLAS detector

Studies of the fragmentation of jets into charged particles in heavy-ion collisions can provide information about the mechanism of jet quenching by the hot and dense QCD matter created in such collisions, the quark-gluon plasma. This paper presents a measurement of the angular distribution of charged particles around the jet axis in sNN=5.02 TeV Pb+Pb and pp collisions, using the ATLAS detector at

Deletion of IRF4 in Dendritic Cells Leads to Delayed Onset of T Cell-Dependent Colitis

Classical dendritic cells (cDC) can be classified into two major subsets: Irf8-dependent cDC1 and Irf4-expressing cDC2. Although these subsets play distinct roles in intestinal immune homeostasis, their functions in T cell-driven colitis remain unknown. To assess the role of IRF4 expression in cDC2 in T cell-driven colitis, CD11c-Cre.Irf4fl/fl and Irf4fl/fl mice were backcrossed onto a Rag-1-/- ba

Status of the Horizon 2020 EuPRAXIA conceptual design study

The Horizon 2020 project EuPRAXIA (European Plasma Research Accelerator with eXcellence In Applications) is producing a conceptual design report for a highly compact and cost-effective European facility with multi-GeV electron beams accelerated using plasmas. EuPRAXIA will be set up as a distributed Open Innovation platform with two construction sites, one with a focus on beam-driven plasma accele

To Drink Bull´s Blood : An analysis of the Story of Midas

This paper deals with the famous account of how Midas committed suicide by drinking bull’s blood. There was a widespread ancient belief that you would die from consuming the blood of a bull, but from a medical point of view it is not poisonous to drink bull’s blood. This paper has its point of departure in this erroneous ancient perception, and analyses what may lay behind the idea that Midas as w

C4BP-IgM protein as a therapeutic approach to treat Neisseria gonorrhoeae infections

Gonorrhea is a sexually transmitted infection with 87 million new cases per year globally. Increasing antibiotic resistance has severely limited treatment options. A mechanism that Neisseria gonorrhoeae uses to evade complement attack is binding of the complement inhibitor C4b-binding protein (C4BP). We screened 107 porin B1a (PorB1a) and 83 PorB1b clinical isolates randomly selected from a Swedis

RTNduals an R/Bioconductor package for analysis of co-regulation and inference of dual regulons

MOTIVATION: Transcription factors (TFs) are key regulators of gene expression, and can activate or repress multiple target genes, forming regulatory units, or regulons. Understanding downstream effects of these regulators includes evaluating how TFs cooperate or compete within regulatory networks. Here we present RTNduals, an R/Bioconductor package that implements a general method for analyzing pa

The Historical Geography of Phrygia : The Settlement of Leonton Kephalai

This article examines the literary evidence for a settlement in Phrygia named Leonton Kephalai, i.e. Lions´Heads. According to preserved literary sources, of which there are only three, Leonton Kephalai was an important military stronghold from the Achaemenid period until the end of the Roman Republic, but the settlement may have been occupied for longer. Furthermore, one literary source specifial