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Osteoporosis in elderly women; Bone traits, fracture and the PTH gene complex
Background: Fragility fractures are a major health problem world wide and the numbers are growing due to ageing populations. Early identification of individuals at risk for osteoporosis and fracture, enabling preventive measures and treatment is essential. Bone strength is partly dependent on lifestyle but genetic factors account for approximately 70-80%. Parathyroid hormone (PTH) is the key regul
WRF-SBM Simulations of Melting-Layer Structure in Mixed-Phase Precipitation Events Observed during LPVEx
Two mixed-phase precipitation events were observed on 21 September and 20 October 2010 over the southern part of Finland during the Light Precipitation Validation Experiment (LPVEx). These events have been simulated using the Weather Research and Forecasting Model coupled with spectral bin microphysics (WRF-SBM). The detailed ice-melting scheme with prognosis of the liquid water fraction during me
Will restrictions on CO2 emissions require reductions in transport demand?
In this paper, the potential for the transportation sector to develop in a way that is consistent with long-term climate targets will be discussed. An important question is whether technical measures will be sufficient for reaching long-term climate targets. Although there is a large potential to significantly increase the use of bioenergy from today's level, there will be severe restrictions to i
Peptide receptor radionuclide therapy (PRRT) using Lu-177-Dotatate: Early clinical and dosimetric results
Food web framework for size-structured populations.
We synthesise traditional unstructured food webs, allometric body size scaling, trait-based modelling, and physiologically structured modelling to provide a novel and ecologically relevant tool for size-structured food webs. The framework allows food web models to include ontogenetic growth and life-history omnivory at the individual level by resolving the population structure of each species as a
The G protein-coupled estrogen receptor 1 (GPER/GPR30) does not predict survival in patients with ovarian cancer
Background: Even though ovarian tumors are not generally considered estrogen-sensitive, estrogens may still have an impact on ovarian tumor progression. The recently identified trans-membrane estrogen receptor GPER is involved in rapid estrogen signaling. Furthermore, it binds selective estrogen receptor modulators with agonistic effect, which could explain tamoxifen controversies. Methods: GPER m
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Prevention and Management of Complications Following Radical Cystectomy for Bladder Cancer
Context: This review focuses on the prevention and management of complications following radical cystectomy (RC) for bladder cancer (BCa). Objective: We review the current literature and perform an analysis of the frequency, treatment, and prevention of complications related to RC for BCa. Evidence acquisition: A Medline search was conducted to identify original articles, reviews, and editorials a
A compact six-port dielectric resonator antenna array: MIMO channel measurements and performance analysis
MIMO systems ideally achieve linear capacity gain proportional to the number of antennas. However, the compactness of terminal devices limits the number of spatial degrees of freedom (DOFs) in such systems, which motivates efficientantenna design techniques to exploit all available DOFs. In this contribution, we present a compact six-port dielectric resonator antenna (DRA) array which utilizes spa
Queer Feelings. Reflections on Zarah Leander and Gay Diva Worship
The Swedish actress and singer Zarah Leander's (1907-81)dark voice, travestie-like persona and her schlager repertoire made her a major gay icon in the 1950s, and she remains an icon in the gay community even today. This essay discusses some aspects of queer feelings and camp aesthetics connected with gay diva worship in the way the 'phenomen Leander' emerged in the postwar period in Sweden and Ge
Advancing Software Development Efficiency in an Open Source Software Context
Open source software has been gaining popularity, especially among commercial organizations. The broad industry acceptance is in large part due to the demonstrated ability of open source solutions to compete with proprietary alternatives. Using open source software components enables companies to reduce their own development costs, and thus improve software development efficiency. Many open source
Reversal of Hofmeister Ordering for Pairing of NH4+ vs Alkylated Ammonium Cations with Halide Anions in Water
Pairing of halide anions with ammonium, as well as with trialkylated and tetraalkylated ammonium cations in water, is investigated by molecular dynamics simulations, which are verified by ab initio calculations and experimental excess chemical potentials. We find that ammonium prefers to pair with smaller halides over the larger ones, while the order is reversed for tetraalkylated ammonium cations
Efficiency of Lift Production in Flapping and Gliding Flight of Swifts
Many flying animals use both flapping and gliding flight as part of their routine behaviour. These two kinematic patterns impose conflicting requirements on wing design for aerodynamic efficiency and, in the absence of extreme morphing, wings cannot be optimised for both flight modes. In gliding flight, the wing experiences uniform incident flow and the optimal shape is a high aspect ratio wing wi
Experiments with Self-Organizing Systems for Texture and Hardness Perception
We have experimented with different SOM-based architectures for bio-inspired self-organizing texture and hardness perception systems. To this end we have developed a microphone based texture sensor and a hardness sensor that measures the compression of the material at a constant pressure. We have implemented and successfully tested both monomodal systems for texture and hardness perception, bimoda
The Type 1 Diabetes - HLA Susceptibility Interactome - Identification of HLA Genotype-Specific Disease Genes for Type 1 Diabetes
Background: The individual contribution of genes in the HLA region to the risk of developing type 1 diabetes (T1D) is confounded by the high linkage disequilibrium (LD) in this region. Using a novel approach we have combined genetic association data with information on functional protein-protein interactions to elucidate risk independent of LD and to place the genetic association into a functional
Adaptive Geometric Numerical Integration of Mechanical Systems
This thesis is about structure preserving numerical integration of initial value problems, i.e., so called geometric numerical integrators. In particular, we are interested in how time-step adaptivity can be achieved in conjunction with structure preserving properties without destroying the good long time integration properties which are typical for geometric integration methods. As a specific app
ROBUST DETECTION AND SPECTRAL ANALYSIS OF SIGNALS WITH APPLICATIONS IN SPECTROSCOPY
Popular Abstract in Swedish De senaste 150 åren har erbjudit en dramatisk utveckling av vår förmåga att sprida både njutningar och smärta, både i form av upptäckter av ämnen såsom TNT och dynamit och framställningen av heroin och Viagra. Denna utveckling har följts av teknologiska framsteg som tillåter studier av dessa kemikalier genom deras interaktion med till exempel radiosignaler eller laser. Modern spectroscopic techniques, such as nuclear quadrupole resonance (NQR), nuclear magnetic resonance (NMR), and Raman spectroscopy, rely heavily on statistical signal processing systems for decision making and information extraction. The first part of this thesis introduces novel robust algorithms for detection, estimation, and classification of signals obtained through these spectroscopic tech
Hitlers egna ord
Recension av Adolf Hitler, Den nationalsocialistiska utrikespolitikens mål.
Democracy - Two Models
Abstract in UndeterminedThe point of departure in my story is the contrast between two models of democratic voting process: popular democracy and what might be called committee democracy. On one interpretation, voting in popular democracy is a procedure whose function is to aggregate the individuals’ preferences to something like a collective preference, while in committee democracy what is being