Recent advances in the field demonstrate the high diversity and complexity of endocytic pathways. In the current study, we focus on the endocytosis of L1CAM. This glycoprotein plays a major role in the development of the nervous system, and is involved in cancer development and is associated with metastases and poor prognosis. Two L1CAM isoforms are subject to endocytosis: isoform 1, described as

Efterord till Katarina Harrison Lindberghs omtolkning av Völsungasagan.

Om krig i Bara härad genom tiderna.

INTRODUCTION: During the judicial process of addressing violent crime, a forensic practitioner may need to assess whether an inflicted injury should be considered life-threatening. This could be important for the classification of the crime. To some extent, these assessments are arbitrary since the natural course of an injury might not be completely known. To guide the assessment, a quantitative a

This article examines positive obligations under the European Convention on Human Rights from the perspective of the level of concreteness chosen for their framing. This level is essential for understanding whether and how the analytical distinction between the existence of an obligation and the breach of this obligation can be applied. The level of concreteness is an important conceptual framewor

OBJECTIVE: General practitioners (GP) are often the first medical professionals to treat musculoskeletal complaints. Yet the impact of COVID-19 on primary care utilisation for musculoskeletal complaints is largely unknown. This study quantifies the impact of the pandemic on primary care utilisation for musculoskeletal complaints and specifically osteoarthritis (OA) in the Netherlands.DESIGN: We ex

Births involving shoulder dystocia or tight nuchal cords can deteriorate rapidly. The fetus may have had a reassuring tracing just before birth yet may be born without any heartbeat (asystole). Since the publication of our first article on cardiac asystole with two cases, five similar cases have been published. We suggest that these infants shift blood to the placenta due to the tight squeeze of t

ObjectiveGestational diabetes mellitus (GDM) is an established risk factor for developing type 2 diabetes mellitus (T2DM) that is possible to prevent by systematic follow-up and preventive measures. The aim of this study was to examine whether women with previous GDM were offered follow-up in primary care, according to Swedish national guidelines.DesignRetrospective review of electronic medical re

The integration of heat pumps in low-enthalpy district heating and cooling networks can increase the efficiency and flexibility of the network. In such systems, heat pumps are installed both locally and centrally to serve different functions. In the former case, decentralized heat pumps at each building adjust the low-network temperature to the desired supply temperature. In the latter case, a cen

The ratio of leaf carotenoid to chlorophyll (Car/Chl) is an indicator of vegetation photosynthesis, development and responses to stress. However, the correlation between Car and Chl, and their overlapping absorption in the visible spectral domain pose a challenge for optical remote sensing of their ratio. This study aims to investigate combinations of vegetation indices (VIs) to minimize the influ