Large stocks of soil organic carbon (SOC) accumulated in the Northern Hemisphere permafrost regions may be vulnerable to climatic warming, but global estimates of SOC distribution and magnitude in permafrost regions still have large uncertainties. Based on multiple high-resolution environmental variables and a compiled soil sample dataset (>3000 soil profiles), we used machine-learning methods to

There is a large body of scientific evidence on the climate crisis and flooding in urban areas. Extreme weather events are producing extensive property damage and loss of life and require new modes of flood governance. However, the climate crisis does not stop at the city limits: peri-urban areas have related but distinct flood challenges due to land use change, regulation, perceptions, and capaci

In this work we construct explicit complex-valued p-harmonic functions on the compact Riemannian symmetric spaces SU(n)/SO(n), Sp(n)/U(n), SO(2n)/U(n), SU(2n)/Sp(n). We also describe how the same can be manufactured on their non-compact symmetric dual spaces.

Despite the recent clinical success of T cell checkpoint inhibition targeting the CTLA-4 and PD-1 pathways, many patients either fail to achieve objective responses or they develop resistance to therapy. In some cases, poor responses to checkpoint blockade have been linked to suboptimal CD28 costimulation and the inability to generate and maintain a productive adaptive anti-tumor immune response.

One of the main factors hampering the implementation in industry of transaminase-based processes for the synthesis of enantiopure amines is their often low storage and operational stability. Our still limited understanding of the inactivation processes undermining the stability of wild-type transaminases represents an obstacle to improving their stability through enzyme engineering. In this paper

Dynamic kinetic resolution (DKR) reactions in which a stereoselective enzyme and a racemization step are coupled in one pot would represent powerful tools for the production of enantiopure amines through enantioconvergence of racemates. The exploitation of DKR strategies is currently hampered by the lack of effective, enzyme-compatible and scalable racemization strategies for amines. In the presen

In pre-industrial Europe, many thousands of ‘middle-class’ individuals retired by purchasing a corrody: a contract allowing them life-long food and lodging, usually by spending their remaining years in a hospital. Given that people usually struggle to prepare for the later stages of life, this article asks whether corrodies were priced in line with the market. We study institutions that specialize

This study, based on a systematic literature review, aims to identify and analyze selected control mechanisms when project success criteria operationalize. The main theoretical contribution of this study involves identifying the dimension of control mechanisms in success criteria operationalization. The most easily identified control mechanisms in the data material were output control mechanisms,

Automated decision-making is prevalent in numerous areas of the public sector. Based on the results of a qualitative, event-based study of how robotic process automation (RPA) is discussed and implemented in social work in Sweden, two questions are answered in this paper: What actors, intentions and network formations appear in the dissemination of RPA in the management of applications for social

Background: The outcome in patients after surgery for acute type A aortic dissection without replacement of the part of the aorta containing the primary tear is undefined. Methods: Data of 1122 patients who underwent surgery for acute type A aortic dissection in 8 Nordic centers from January 2005 to December 2014 were retrospectively analyzed. The patients with primary tear location unfound, unkno

Om platser verkligen är av betydelse, vilket ekonomiska geografer anser, då måste de vara som mest betydelsefulla för de människor vars liv utspelar sig på dessa platser, och upplever världen, materiellt kan kulturellt, genom den. När en kris och efterföljande osäkerheter drabbar en plats så påverkar detta främst människorna som kallar denna platsen för sitt hem. Ibland till den grad att en del avIf places indeed matter, as economic geographers believe, then it must matter most to the people who live their everyday lives in these places and experience the world materially and socially through it. When a crisis hits and uncertainty ensues, it affects people who call these places home the most. So much so, that some of them might be willing to stake a claim on its recovery, and development t

During 2020 archives and museums collected both personal memories and artifacts related to the corona outbreak. The aim was to document the unique situation and to save memories for the future. How can the experiences from this year be used in cooperation between academia and archives and museums?

This release brings together some of Ponce’s finest guitar works, carefully selected and sensitively performed by Bertrand Chavarría-Aldrete. The album opens with a Preludio written not long after Ponce arrived in Paris, characterised by modal and whole tone inflections that lend the piece an impressionistic quality. The release also includes the later set of Seis preludios cortos (‘Six short prel

RATIONALE AND OBJECTIVES: Thymic stromal lymphopoietin (TSLP), an epithelial upstream cytokine, initiates production of type-2 (T2) cytokines with eosinophilia and possibly airway hyperresponsiveness (AHR) in asthma.This study aimed to determine whether tezepelumab (a human monoclonal antibody targeting TSLP) decreases AHR and airway inflammation in patients with symptomatic asthma on maintenance

A γ-ray spectroscopic study of 212Po was performed at the Grand Accélérateur National d'Ions Lourds, using the inverse kinematics α-transfer reaction 12C(208Pb,212Po)8Be and the AGATA spectrometer. A careful analysis based on γγ coincidence relations allowed us to establish 14 new excited states in the energy range between 1.9 and 3.3 MeV. None of these states, however, can be considered as candid

ELI Beamlines is a rapidly progressing pillar of the pan-European Extreme Light Infrastructure (ELI) project focusing on the development and deployment of science driven by high-power lasers for user operations. This work reports the results of a commissioning run of a water-jet plasma X-ray source driven by the L1 Allegra laser, outlining the current capabilities and future potential of the syste

With the goal to delevop the fabrication of a new type of Pt-nanoparticle carbon-support electrocatalyst, we investigate the carbon embedding of Pt cluster superlattices grown on the moiré of a monolayer of hexagonal boron nitride (h-BN) on Ir(111). Our combined scanning tunneling microscopy (STM) and X-ray photoelectron spectroscopy (XPS) study establishes conformal C embedding of the Pt clusters

Pancreatic cancer, despite being the most dreadful among gastrointestinal cancers, is poorly diagnosed, and further, the situation has been aggravated owing to acquired drug resistance against the single known drug therapy. While previous studies have highlighted the growth inhibitory effects of older generation fluoroquinolones, the current study aims to evaluate the growth inhibitory effects of