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Agonistic CD40 antibodies activate dendritic cells and can expand and activate tumor-specific T cells. Our purpose was to assess the CD40 agonistic antibody ADC-1013 in the clinical setting including intratumoral administration since preclinical studies have indicated that intratumoral is better than intravenous administration. A Phase I, open label, multicenter study was conducted in patients wit

Background: The CTLA-4 blocking antibody ipilimumab has demonstrated substantial and durable effects in patients with melanoma. While CTLA-4 therapy, both as monotherapy and in combination with PD-1 targeting therapies, has great potential in many indications, the toxicities of the current treatment regimens may limit their use. Thus, there is a medical need for new CTLA-4 targeting therapies wit

Fruit juices are widely consumed due to their affordability, nutritional value, and convenience. As global health consciousness rises, the fruit juice market is projected to grow from $153.17 billion in 2024 to $209.51 billion by 2029. Membrane processes, first introduced in the 1970s, have become essential in juice production, offering precise separation at low temperatures. The fruit juice indus

Uppslagsord: mellankrigstiden i Nationalencyklopedin.

Uppslagsord: Waffen-SS i Nationalencyklopedin

Uppslagsord under "Historia", historia som skolämne i Nationalencyklopedin.

Uppslagsord: Lima i Nationalencyklopedin.

Uppslagsord: Raoul Wallenberg i Nationalencyklopedin.

Uppslagsord: Berlinkonferensen i Nationalencyklopedin.

Uppslagsord: Raphael Lemkin i Nationalencyklopedin.

Uppslagsord: historiebruk i Nationalencyklopedin.

Background: The Swedish housing stock generally maintains a high standard. However, earlier policies prioritized quantity and rapid housing production targeting a younger population, over policies that require accessible housing design. With an aging population, evidence-based policies supporting ageing in place while managing societal costs are crucial. This thesis aimed to increase the knowledge

The vast potential of using sediment adsorbed DNA as a window to past and present biodiversity rely on the ability of solid surfaces to adsorb environmental DNA. However, a comprehensive insight into DNA adsorption at surfaces in general is lacking. Soot and charcoal are carbonaceous materials widespread in the environment where they read-ily can come in contact with extracellular DNA shed from or

Transformative advertising research (TAR) suggests examining advertising’s transformational possibilities via the interactions between institutional actors at each marketing level to gauge its effect on society. We employ rhetorical institutionalism as a lens to examine the online speech acts of consumers as they respond to a brand activism campaign focusing on an environmental problem. Our data t