Signaling via β₂ integrins triggers neutrophil-dependent alteration in endothelial barrier function

Activation of polymorphonuclear leukocytes (PMNs) and adhesion to the endothelial lining is a major cause of edema formation. Although known to be dependent on the function of β2 integrins (CD11/CD18), the precise mechanisms by which adherent PMNs may impair endothelial barrier capacity remain unclear. Here, the role of transmembrane signaling by β2 integrins in PMN-induced alterations in tight ju

Zinc-dependent conformational changes in domain D5 of high molecular mass kininogen modulate contact activation

Human high molecular mass kininogen (HK) participates as nonenzymatic cofactor in the contact system. Here, we show that recombinant domain D5 of HK (rD5) prolongs the clotting time of the intrinsic pathway of coagulation and attenuates the generation of bradykinin. Further studies indicate that a correct fold of domain D5 within HK is required for the activation of the contact system. The folding

Staphylococcus aureus induces release of bradykinin in human plasma

Staphylococcus aureus is a prominent human pathogen. Here we report that intact S. aureus bacteria activate the contact system in human plasma in vitro, resulting in a massive release of the potent proinflammatory and vasoactive peptide bradykinin. In contrast, no such effect was recorded with Streptococcus pneumoniae. In the activation of the contact system, blood coagulation factor XII and plasm

Journal of Innate Immunity : Editors' choice

Bacterial Abuse of Mammalian Extracellular Proteases during Tissue Invasion and Infection

A summing-up of 2010 in the journal of innate immunity

Diagnostic accuracy of troponin T measured ≥6h after symptom onset for ruling out myocardial infarction

Objectives: Guidelines recommend a single high-sensitivity cardiac troponin T (hs-cTnT) ≤14 ng/L measured ≥6 h after chest pain onset combined with a GRACE score

Diagnostic Accuracy of History and Physical Examination for Predicting Major Adverse Cardiac Events Within 30 Days in Patients With Acute Chest Pain

BACKGROUND: The cornerstones in the assessment of emergency department (ED) patients with suspected acute coronary syndrome (ACS) are patient history and physical examination, electrocardiogram, and cardiac troponins. Although there are several prior studies on this subject, they have in some cases produced inconsistent results.OBJECTIVE: The aim of this study was to evaluate the diagnostic and pr

Conversing with Clothes : Germanos and Mary’s Belt

The Virgin in Song : Mary and the Poetry of Romanos the Melodist

The Reception of the Virgin in Byzantium : Marian Narratives in Texts and Images

The Dialogue of Annunciation : Germanos of Constantinople versus Romanos the Melode

Introduction

Soundscapes of Salvation : Resounding Refrains in Jewish and Christian Liturgical Poems

Constitutional Rights for Children in Sweden

Remissyttrande: Förbättrat skydd för totalförsvaret (SOU 2019:34)

Remissyttrande: Promemorian Förstärkt nedsättning av arbetsgivaravgifter för personer som arbetar med forskning eller utveckling

Apprentices in Swedish urban Crafts in the 19th century : From guild regulation to free market conditions

Recommendations of the Polish Society of Physiotherapy, the Polish Society of Family Medicine, the College of Family Physicians in Poland and the European Rural and Isolated Practitioners Association regarding the use of simple forms of Physiotherapy, including massage and self-massage in primary care, endorsed by the Polish Society of Physiotherapy Specialists

Background. In general practice, dysfunctions within the locomotor system are a recurring health issue. Most frequently, diagnoses and treatments relate to pain syndromes of the backbone, the shoulder girdle or the pelvic girdle. The authors believe that physiotherapy, along with other clinical disciplines, should be regarded as an important factor which influences the effectiveness of the therape

Remissyttrande: Santiagokonventionen mot organhandel (SOU 2019:01)