PurposeTo map T1 and the local flip angle (B1+) in human brain using a single MP3RAGE sequence with 3 rapid acquisitions of gradient echoes (RAGEs).Theory and methodsA third RAGE with a relatively high flip angle was appended to an MP2RAGE sequence. Through curve fitting and a rational approximation for small flip angles and short TR, closed form solutions for T1 and B1+ were derived. The influenc

This study aimed to describe the incidence of Streptococcus bovis/Streptococcus equinus complex (SBSEC) bacteremia, distribution of the SBSEC subspecies, and their respective association with colorectal cancer (CRC). A population-based retrospective cohort study of all episodes of SBSEC-bacteremia from 2003 to 2018 in Skåne Region, Sweden. Subspecies was determined by whole-genome sequencing. Medi

Background: Despite intense research, the prognosis for patients with advanced colorectal cancer (CRC) remains poor. The prostaglandin D2 receptors DP1 and DP2 are explored here as potential therapeutic targets for advanced CRC. Methods: A CRC cohort was analysed to determine whether DP1 and DP2 receptor expression correlates with patient survival. Four colon cancer cell lines and a zebrafish meta

Objective Deconvolution is an ill-posed inverse problem that tends to yield non-physiological residue functions R(t) indynamic susceptibility contrast magnetic resonance imaging (DSC-MRI). In this study, the use of Bézier curves is proposedfor obtaining physiologically reasonable residue functions in perfusion MRI.Materials and methods Cubic Bézier curves were employed, ensuring R(0)=1, bounded-in

INTRODUCTION: Primary graft dysfunction (PGD) is a leading cause of 30-day mortality following heart transplantation, and early intervention in PGD may correlate to improved survival. Our analysis aimed to determine the feasibility of measuring cardiac biomarkers from the donor heart in the early phase for use as a predictor of PGD.METHODS: Blood samples from the coronary sinus were obtained at th

The effect of clock skew and duty-cycle on the performance of high-Q N-phase band-pass filters (BPFs) have been examined in this paper. Following a mathematical approach and using the analytical derivations carried out, the effects of such non-idealities as clock skew and duty-cycle error are determined in an N-path filter. It is analytically proved that image signals from all integer multiples of

We have measured the 3d→2p transition x rays of kaonic 3He and 4He atoms using superconducting transition-edge-sensor microcalorimeters with an energy resolution better than 6 eV (FWHM). We determined the energies to be 6224.5±0.4(stat)±0.2(syst) eV and 6463.7±0.3(stat)±0.1(syst) eV, and widths to be 2.5±1.0(stat)±0.4(syst) eV and 1.0±0.6(stat)±0.3(stat) eV, for kaonic 3He and 4He, respectively.

Structural changes and neuropathology in the hypothalamus have been suggested to contribute to the non-motor manifestations of Huntington’s disease (HD), a neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin (HTT) gene. In the present study, we investigated whether transcriptional changes would be part of hypothalamic pathology induced by the disease-causing huntingtin (H

The production of Λ baryons and KS0 mesons (V0 particles) was measured in p–Pb collisions at sNN=5.02 TeV and pp collisions at s=7 TeV with ALICE at the LHC. The production of these strange particles is studied separately for particles associated with hard scatterings and the underlying event to shed light on the baryon-to-meson ratio enhancement observed at intermediate transverse momentum (pT) i

A search with minimal model dependence for physics beyond the Standard Model in events featuring three or four charged leptons (3ℓ and 4ℓ, ℓ=e,μ) is presented. The analysis aims to be sensitive to a wide range of potential new-physics theories simultaneously. This analysis uses data from pp collisions delivered by the Large Hadron Collider at a centre-of-mass energy of s=13 TeV and recorded with t

In the last two decades, the retail sector has experienced unprecedented upheaval, having severe implications for economic development and sustenance of traditional inner-city retail dis-tricts. In the city of Christchurch, New Zealand, this effect has been exacerbated by a series of earthquakes in 2010/2011 which destroyed much of the traditional retail precinct of the city. After exten-sive rebu

Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive bronchoscopic procedure, well established as a diagnostic modality of first choice for diagnosis and staging of non-small cell lung cancer (NSCLC). The therapeutic decisions for advanced NSCLC require comprehensive profiling of actionable mutations, which is currently considered to be an essential

Disasters exact a heavy toll globally. However, the degree to which we can accurately quantify their impact, in particular mortality, remains challenging. It is critical to ensure that disaster data reliably reflects the scale, type, and distribution of disaster impacts given the role of data in: (1) risk assessments; (2) developing disaster risk management programs; (3) determining the resources

Growing evidence suggests a consistent association between atrial fibrillation (AF) and cognitive impairment and dementia that is independent of clinical stroke. This report from the AF-SCREEN International Collaboration summarizes the evidence linking AF to cognitive impairment and dementia. It provides guidance on the investigation and management of dementia in patients with AF on the basis of b

BackgroundHealth systems are based on 6 functions that need to work together at all times to effectively deliver safe and quality health services. These functions are vulnerable to shocks and changes; if a health system is unable to withstand the pressure from a shock, it may cease to function or collapse. The concept of resilience has been introduced with the goal of strengthening health systems

Large stocks of soil organic carbon (SOC) accumulated in the Northern Hemisphere permafrost regions may be vulnerable to climatic warming, but global estimates of SOC distribution and magnitude in permafrost regions still have large uncertainties. Based on multiple high-resolution environmental variables and a compiled soil sample dataset (>3000 soil profiles), we used machine-learning methods to

There is a large body of scientific evidence on the climate crisis and flooding in urban areas. Extreme weather events are producing extensive property damage and loss of life and require new modes of flood governance. However, the climate crisis does not stop at the city limits: peri-urban areas have related but distinct flood challenges due to land use change, regulation, perceptions, and capaci