Biomarker detection via lab-on-a-chip integrated immunoaffinity approach for fluorescence and mass spectrometry readout
Popular Abstract in English The human plasma proteome containing disease-correlated protein biomarkers reflects the pathological and physiological changes relating to diseases. These biomarkers are of interest to aid in diagnosis, prognosis and monitoring of diseases such as cancer. Because of the interests in the disease-correlated biomarkers, plasma, although is a complex biological sample, spanThe blood/plasma protein biomarker profile represents the pathological and physiological changes relating to human diseases. However, the plasma proteome reflects a high degree of complexity that results in a challenge for most analytical methods in clinical diagnostics. The focus in this thesis is the development and application of several integrated platforms to detect already established protei