Perlecan is a heparan-sulfate proteoglycan abundantly expressed in pericellular matrices and basement membranes during development. Inactivation of the perlecan gene in mice is lethal at two developmental stages: around E10 and around birth. We report a high incidence of malformations of the cardiac outflow tract in perlecan-deficient embryos. Complete transposition of great arteries was diagnosed

Abstract. Söderberg S, Ahrén B, Eliasson M, DinesenB, Olsson T (Umeå University, Umeå, Lund University and Luleå Hospital, Lund, Sweden; and Steno Diabetes Center, Gentofte, Denmark). The association between leptin and proinsulin is lost with central obesity. J Intern Med 2002; 252: 140-148. OBJECTIVE: Hyperproinsulinaemia and hyperleptinaemia are interrelated features of the insulin resistance sy

This report presents theories and measurements of the mechanisms af heat transfer in fibrous materials (e.g. insulation of mineral wool type), and measurements of these mechanisms. The present work is part af a larger research program at the Division of Building Technology, Lund Institute of Technology, for investigating the behaviour of fibrous material as thermal insulation. A preliminary versio

We report on the applications of a single-longitudinal-mode (SLM) pulsed alexandrite laser system for diagnostics of parameters of flow/combustion interest. The laser system is characterized by its narrow linewidth, high peak power, and broad tunablity. The absolute frequency of the laser output was monitored by a wavelength diagnostic system, which included a high-resolution confocal etalon and a

Popular Abstract in Swedish Om modellbibliotek för termo-hydrauliska tillämpningar. Matematiska modeller och simulering är viktiga verktyg för att hantera tekniska system. Speciellt som trenden idag är att öka komplexiteten i system genom integrerad produktion och processoptimering. Att hantera dessa komplexa system kräver kunskaper inom många områden samtidigt. Modellbibliotek är ett bra sätt atMathematical modelling and simulation are important tools when dealing with engineering systems that today are becoming increasingly more complex. Tightly integrated production and process optimization are trends that give rise to heterogeneous systems, which are difficult to handle without expertise in several engineering disciplines. Model libraries provide an excellent way to package engineerin

The β-delayed neutron branches from neutron-rich Be-isotopes have been measured with a setup sensitive down to thermal energies. For 14Be a new value of Pn = 101 ± 4% has been found for the total neutron-emission probability and an upper limit of 2.4% (95% confidence level) is imposed on the combination P2n + 3P3n of multi-neutron emission probabilities. Moreover, an improved value of Pn = 0.50 ±

Several lines of evidence suggest that wetlands may be a major source of methylmercury (MeHg) to receiving waters, perhaps explaining the strong correlation between concentrations of waterborne MeHg and dissolved organic carbon (DOC) in regions such as northern Wisconsin. We evaluated the relative importance of wetland export in the MeHg budget of a wetland-dominated lake in northern Wisconsin usi

The fouling tendency, due to adsorption on the pore walls, of two pairs of modified and unmodified ultrafiltration membranes, with similar observed retentions determined by dextran and gel permeation chromatography, was studied. The membranes investigated were made of modified and unmodified polyaramide (PA) and modified and unmodified polyvinylidene fluoride (PVDF). The PVDF membrane was surface-

OBJECTIVE Serum Hsp60 and anti-Hsp65 antibody levels are raised in subjects with borderline hypertension, and there is an association between circulating Hsp60 levels and early atherosclerosis. Given the recognized relationship between hypertension and atherosclerosis, this study determined heat shock protein and heat shock protein antibody levels in subjects with established hypertension.METHODS

Popular Abstract in Swedish Vad hade vi varit utan våra sinnen? Föreställ dig en värld utan att kunna se, höra, lukta, smaka och känna. Det är med hjälp av våra sinnen som kroppen kan känna vad som händer i vår omgivning. Ett av våra sinnen är smärtsinnet, som har till uppgift att varna oss för inre och yttre faror. Trots att smärta är den i särklass vanligaste orsaken till mänskligt lidande, så äIt is frequently argued that cannabinoids exert part of their analgesic and anti-inflammatory effects via activation of the cannabinoid CB1 receptor located on TRPV1-expressing primary sensory nerve fibres in peripheral tissues. However, we find no evidence of CB1 receptor immunoreactivity on nerve fibres in rat or mouse hindpaw skin and mesenteric artery. The CB1 receptor agonists anandamide and

To obtain a perspective of changes occurring in the marine environment it is essential to study an area over a long time span. Doing so might also facilitate the understanding of the mechanisms and processes that govern a certain marine setting. In this thesis, changes in the pelagic and benthic environment during the last c. 200 years have been investigated in two fjords on the Swedish west coast

In crossing theory for stochastic processes the distribution of quantities such as distances between level crossings, maximum height of an excursion between level crossings, amplitude and wavelength, etc., can only be written in the form of infinite-dimensional integrals, which are difficult to evaluate numerically. A Slepian model is an explicit random function representation of the process after

Phosphatidylethanol (PEth) is an abnormal phospholipid, formed only in the presence of ethanol via a transphosphatidylation reaction of phospholipase D (PLD). PEth in blood is a promising new marker of alcohol abuse. Blood PEth is found almost exclusively in red cells. This study was performed to investigate a possible PEth formation in human red cells from alcoholics and healthy individuals, at p

OBJECTIVE: This study aims to examine the association between various measures of adiposity and all-cause mortality in Swedish middle-aged and older men and women and, additionally, to describe the influences of age and sex on these associations. RESEARCH METHODS AND PROCEDURES: A prospective analysis was performed in a cohort of 10,902 men and 16,814 women ages 45 to 73 years who participated in

Flight directions of birds migrating at high geographic and magnetic latitudes can be used to test bird orientation by celestial or geomagnetic compass systems under polar conditions. Migration patterns of arctic shorebirds, revealed by tracking radar studies during an icebreaker expedition along the Northwest Passage in 1999, support predicted sun compass trajectories but cannot be reconciled wit

The use of grey-scale ultrasound morphology to characterize a pelvic mass may also be called ‘pattern recognition’. The grey-scale ultrasound image provides us with the same information as that obtained by the surgeon or pathologist when he or she cuts a surgical specimen to see what it looks like inside. Many pelvic masses have such a typical macroscopic appearance that a fairly confident diagnos

The band structure of Zr-83 has been investigated using the Daresbury recoil separator and TESSA array with 20 Compton suppressed Ge detectors and the reaction Si-28 (Ni-58, 2pn) at 195 MeV. DCO ratios have been used to make many new spin assignments. The three known rotational bands have been extended up to the onset of the five quasiparticle bands. On the basis of the 21/2+, 23/2+ and 25/2+ yras